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IL-17A

IL-17A Molecule Information

Name:Interleukin 17A
Target Synonym:Interleukin-17A;CTLA8 ;IL-17A;CTLA-8;IL17;IL-17;Cytotoxic T-lymphocyte-associated antigen 8;IL17A
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

IL-17A Protein Product ListCompare or Buy

IL-17A Part of Bioactivity data

CT8-M5240-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Mouse IL-17A, His Tag (Cat. No. CT8-M5240) stimulates secretion of IL-6 by NIH-3T3 cells. The ED50 for this effect is 2.132-5.005 ng/mL.

ILA-H5118-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL17/ IL17A Protein, Free Tag(Cat. No. ILA-H5118) stimulates secretion of IL-6 by NIH-3T3 cells. The ED50 for this effect is 1.444-6.941 ng/ml.

CT8-M5240-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) on Protein A Biosensor, can bind Mouse IL-17A, His Tag (Cat. No. CT8-M5240) with an affinity constant of 20.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ILA-H5118-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) on Protein A Biosensor, can bind Human IL17A, Tag Free (Cat. No. ILA-H5118) with an affinity constant of 0.21 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL-17A Molecule Synonym Name

IL-17A,Interleukin-17A,CTLA-8,IL-17

IL-17A Molecule Background

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

IL-17A References

IL-17A Related Molecule

IL-17A Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Virulizin Approved Aptose, Symbion Health, Zor Pharmaceuticals Gastric cancer, Colorectal cancer, Renal carcinoma, Cervical carcinoma, Kaposi's sarcoma, Pancreatic cancer, Melanoma Details
Ixekizumab LY-2439821, LY2439821 Approved Lilly TALTZ fda Plaque psoriasis ELI LILLY AND CO 2016-03-22 Psoriatic erythroderma, Ankylosing Spondylitis (AS), Plaque psoriasis, Pustular psoriasis, Psoriatic arthritis, Psoriasis vulgaris Details
Secukinumab AIN-457; KB-03303A; NVP-AIN-457 Approved Novartis, Maruho Pharmaceutical Secukinumab 日本 Psoriasis vulgaris, Psoriatic arthritis 诺华,Maruho Pharmaceutical 2014-12-26 00:00:00.0 Plaque psoriasis, Ankylosing Spondylitis (AS), Pustular psoriasis, Psoriasis, Psoriatic arthritis, Psoriasis vulgaris Details

IL-17A Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Tibulizumab (Eli Lilly) Phase Ⅰ Lilly Sjoegren's syndrome Details
ALX-0761 ALX-0761; M-1095; MSB-0010841 Phase Ⅱ Ablynx, Merck Serono Psoriasis Details
GR-1501 GR-1501,GR1501; GR 1501 Phase Ⅰ Chongqing Genrix Biopharmaceutical, Genrix (Shanghai) Biopharmaceutical Spondyloarthritis, Plaque psoriasis Details
JNJ-63823539 JNJ-63823539 Phase Ⅰ Janssen Rheumatoid arthritis (RA) Details
RO-7040547 BIT-7201A; RG-7990; RO-7040547 Phase Ⅰ Genentech Allergic asthma Details
Vidofludimus 4SC-101; SC-12267,4SC101,SC12267 Phase Ⅱ 4SC AG Ulcerative colitis, Crohn's disease Details
Recombinant humanized anti-IL17A monoclonal antibody(Shanghai CP Guojian) 608 Phase Ⅰ Shanghai CP Guojian Plaque psoriasis Details
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) Phase Ⅰ Livzon Pharmaceutical Group, Beijing Xinkanghe Biomedical Technology Co., Ltd. Plaque psoriasis Details
Recombinant anti-IL-17A humanized monoclonal antibody (Shanghai Junshi Biosciences) JS005 Phase Ⅰ Shanghai Junshi Biosciences Plaque psoriasis, Psoriasis, Rheumatoid arthritis (RA) Details
COVA-322 COVA-322 Phase Ⅱ Covagen Plaque psoriasis Details
UCB-0159 UCB-0159 Phase Ⅰ UCB Autoimmune diseases Details
Vunakizumab SHR-1314 Phase Ⅱ Jiangsu Hengrui Medicine Spondyloarthritis, Plaque psoriasis Details
ABY-035 ABY-035; AFB-035 Phase Ⅰ Affibody Psoriasis Details
Recombinant anti-IL-17A humanized monoclonal antibody (Shanghai CP Guojian) Phase Ⅰ Shanghai CP Guojian Plaque psoriasis Details
SCH-900117 SCH-900117; SCH900117 Phase Ⅰ Merck Sharp & Dohme Rheumatoid arthritis (RA) Details
CJM-112 CJM-112 Phase Ⅱ Novartis Plaque psoriasis, Hidradenitis suppurativa, Multiple sclerosis (MS) Details

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