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IL-17A

Brief Information

Name:Interleukin 17A
Target Synonym:CTLA8,IL17A,Interleukin 17A,Cytotoxic T-Lymphocyte-Associated Antigen 8,Cytotoxic T-Lymphocyte-Associated Protein 8,CTLA-8,IL-17A,IL-17,IL17,Interleukin-17A,Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

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Part of Bioactivity data

CT8-M5240-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Mouse IL-17A, His Tag (Cat. No. CT8-M5240) stimulates secretion of IL-6 by NIH-3T3 cells. The ED50 for this effect is 2.132-5.005 ng/mL.

ILA-H5118-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL17/ IL17A Protein, Free Tag(Cat. No. ILA-H5118) stimulates secretion of IL-6 by NIH-3T3 cells. The ED50 for this effect is 1.444-6.941 ng/ml.

ILA-H82Q1-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human IL17A, His,Avitag (Cat. No. ILA-H82Q1) on SA Biosensor, can bind Human IL-17 RA, His Tag (Cat. No. ILA-H5222) with an affinity constant of 18.8 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

CT8-M5240-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) on Protein A Biosensor, can bind Mouse IL-17A, His Tag (Cat. No. CT8-M5240) with an affinity constant of 20.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL-17A,Interleukin-17A,CTLA-8,IL-17

Background

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Virulizin Approved Aptose Virulizin, Virulizin-2 gamma Mexico Sarcoma, Kaposi; Melanoma; Carcinoma, Renal Cell; Colorectal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Uterine Cervical Neoplasms null 1997-01-01 Carcinoma, Renal Cell; Stomach Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Sarcoma, Kaposi; Melanoma; Uterine Cervical Neoplasms Details
Ixekizumab LY-2439821 Approved Eli Lilly And Company 拓咨, Taltz EU Spondylitis, Ankylosing Eli Lilly Nederland Bv 2016-03-22 Non-radiographic axial spondyloarthritis; Spondylarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic Details
Secukinumab AIN-457; KB-03303A; NVP-AIN-457 Approved Novartis Pharma Ag 可善挺, Cosentyx United States Non-radiographic axial spondyloarthritis Novartis Pharmaceuticals Corp 2014-12-26 Psoriasis; Crohn Disease; Plaque psoriasis; Gastroenteritis; Behcet Syndrome; Hidradenitis Suppurativa; Uveitis; Arthritis; Asthma; Parapsoriasis; Lichen Planus; Arthritis, Psoriatic; Tendinopathy; Non-radiographic axial spondyloarthritis; Graves Ophthalmopathy; Multiple Sclerosis; Arthritis, Juvenile; Lupus Nephritis; Arthritis, Rheumatoid; Spondylarthritis; Spondylitis, Ankylosing; Giant Cell Arteritis; Inflammatory Bowel Diseases; Non-alcoholic Fatty Liver Disease; Diabetes Mellitus, Type 1; Multiple Sclerosis, Relapsing-Remitting Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
JNJ-63823539 JNJ-63823539 Phase 1 Clinical Janssen Global Services Llc Arthritis, Rheumatoid Details
UCB-0159 UCB-0159 Phase 1 Clinical Ucb Sa Autoimmune Diseases Details
COVA-322 COVA-322 Phase 2 Clinical Covagen Psoriasis Details
ALX-0761 M-1095; ALX-0761; MSB-0010841 Phase 2 Clinical Ablynx Psoriasis Details
Vidofludimus 4SC-101; SC-12267 Phase 2 Clinical 4sc Ag Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease Details
ZL-1102 ZL-1102 Phase 1 Clinical Zai Lab (Shanghai) Co Ltd Psoriasis Details
Recombinant anti-IL-17A humanized monoclonal antibody (Shanghai Junshi Biosciences) JS005 Phase 2 Clinical Shanghai Junshi Biosciences Co Ltd Arthritis, Rheumatoid; Psoriasis; Plaque psoriasis Details
QX002N QX-002N Phase 1 Clinical Jiangsu Quanxin Biomedical Co Ltd Spondylitis, Ankylosing Details
Recombinant anti-IL-17A humanized monoclonal antibody (Shanghai CP Guojian) Phase 2 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Psoriasis; Plaque psoriasis Details
GR-1501 GR-1501 Phase 3 Clinical Zhixiang (Shanghai) Pharmaceutical Technology Co Ltd, Chongqing Zhixiang Jintai Biopharmaceutical Co Ltd Spondylarthritis; Psoriasis; Plaque psoriasis Details
BAT-2306 Phase 1 Clinical Bio-Thera Solutions Ltd Autoimmune Diseases; Psoriasis Details
CJM-112 CJM-112 Phase 2 Clinical Novartis Pharma Ag Acne Vulgaris; Triple Negative Breast Neoplasms; Multiple Myeloma; Multiple Sclerosis; Psoriasis; Colorectal Neoplasms; Asthma; Hidradenitis Suppurativa; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) LZM-012; LZM012 Phase 2 Clinical Livzon Pharmaceutical Group Inc, Beijing Xinkanghe Biomedical Technology Co Ltd Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
ABY-035 AFB-035; ABY-035; IMG-020; IMG020 Phase 2 Clinical Affibody Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Uveitis Details
AK-111 AK-111 Phase 2 Clinical Zhongshan Akeso Biopharma Co Ltd Spondylarthritis; Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
Recombinant humanized anti-IL17A monoclonal antibody(Shanghai CP Guojian) 608 Phase 1 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Psoriasis Details
Vunakizumab SHR-1314 Phase 3 Clinical Jiangsu Hengrui Medicine Co Ltd Spondylarthritis; Autoimmune Diseases; Spondylitis, Ankylosing; Lupus Nephritis; Psoriasis; Plaque psoriasis Details

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