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Your Position: Home > Integrin alpha V beta 3

Integrin alpha V beta 3

Brief Information

Name:Integrin alpha-V/beta-3
Target Synonym:Integrin alphaVbeta3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:22
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

 Integrin alpha V beta 3 ELISA

Immobilized Human Vitronectin at 5 μg/mL (100 μL/well) can bind Biotinylated Human ITGAV&ITGB3 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT3-H82W9) with a linear range of 0.039-2.5 μg/mL (QC tested).

Integrin alpha V beta 3 MALS images

The purity of Rat ITGAV&ITGB3 Heterodimer, His Tag&Tag Free (Cat. No. IT3-R52E2) is more than 85% and the molecular weight of this protein is around 210-240kDa verified by SEC-MALS.

Synonym Name

Integrin alpha V beta 3,ITGAV&ITGB3


Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
99mTc-3PRGD2 99mTc-3PRGD2 Phase 3 Clinical Peking University Lymphatic Metastasis; Lung Neoplasms Details
Alfatide[18F] 18F-AlF-NOTA-PRGD2; 18F-alfatide; alfatide II; AlF-NOTA-PRGD2-[18F] Phase 3 Clinical Jiangsu Smk Pharmaceutical Co Ltd, Taizhou Kairui Pharmaceutical Technology Co Ltd Carcinoma, Bronchogenic; Head and Neck Neoplasms; Neoplasms; Soft Tissue Neoplasms; Breast Neoplasms; Contrast agents; Lymphoma Details
IDL-2965 IDL-2965 Phase 2 Clinical Indalo Therapeutics Inc Metabolic Dysfunction-Associated Steatotic Liver Disease; Idiopathic Pulmonary Fibrosis Details
AS-101 PRX-0001/AS101; WAX-120337; IVAX-Q-101; IVX-Q-101; CB-06-02; AS-101; PRX-001; PRX-0002/AS101 Phase 2 Clinical Biomas Ltd Alopecia; HIV Infections; Warts; Myelodysplastic Syndromes; Psoriasis; Leukemia, Myeloid, Acute; Thrombocytopenia; Macular Degeneration; Dermatitis, Atopic; Condylomata Acuminata Details
Nesvategrast OTT-166(OcuTerra Therapeutics); SF-0166 Phase 2 Clinical Scifluor Life Sciences Inc, OcuTerra Therapeutics Inc Diabetic macular oedema; Diabetic Retinopathy; Macular Degeneration Details
Ga-68 NODAGA-RGD [68Ga]Theranost; Theranost 68Ga-RGD Phase 1 Clinical Advanced Imaging Projects, Zentralklinik Bad Berka, National Cancer Institute Neovascularization, Pathologic; Lung Neoplasms Details
Risuteganib ALG-1001; AM011; AM-011(Allegro Ophthalmics) Phase 1 Clinical Allegro Ophthalmics Llc Diabetic macular oedema; Geographic Atrophy; Macular Degeneration; Diabetic Retinopathy Details
68Ga-NOTA-BBN-RGD 68Ga-NOTA-BBN-RGD Phase 1 Clinical Peking Union Medical College Hospital Breast Neoplasms; Prostatic Neoplasms Details
BGC-0222 BGC0222; BGC-0222 Phase 1 Clinical Gaorui Yaoye (Beijing) Technologies Co Ltd, Brightgene Bio-Medical Technology Co Ltd Solid tumours Details
Antiangiotide HM-3; IIM-3 Phase 1 Clinical Inner Mongolia Tianqi Pharmaceutical Group Co Ltd, China Pharmaceutical University Solid tumours; Liver Neoplasms; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung Details
68Ga-NOTA-3PTATE-RGD 68Ga-NOTA-3PTATE-RGD; 68Ga-NOTA-3P-TATE-RGD Phase 1 Clinical Peking Union Medical College Hospital Small Cell Lung Carcinoma; Neuroendocrine Tumors; Lung Neoplasms Details
Transferrin OCU-200 Phase 1 Clinical Ocugen Inc Wet Macular Degeneration; Diabetic macular oedema; Diabetic Retinopathy Details
VIP-236 VIP-236 Phase 1 Clinical Bayer AG Solid tumours; Neoplasms Details
177Lu-FF-58 177Lu-FF58; 177-Lu-FF-58; 177Lu-FF-58; [177Lu]Lu-FF58 Phase 1 Clinical Advanced Accelerator Applications Sa Esophageal Neoplasms; Stomach Neoplasms; Glioblastoma; Carcinoma, Pancreatic Ductal Details
68Ga-FAPI-RGD 68Ga-FAPI-RGD Phase 1 Clinical Peking Union Medical College Hospital Lung Neoplasms Details
68Ga-HX01 68GaHX01; 68Ga-HX01 Phase 1 Clinical Hexin (Suzhou) Pharmaceutical Technology Co Ltd Solid tumours; Contrast agents Details
(68)Ga-RGD Phase 1 Clinical Peking Union Medical College Hospital Keloid Details
fb-PMT NP-100; NP-751 Phase 1 Clinical NanoPharmaceuticals LLC Glioma Details
ProAgio Phase 1 Clinical National Cancer Institute Solid tumours; Pancreatic Neoplasms Details
[68Ga]-FF58 Phase 1 Clinical Novartis Pharma Ag Stomach Neoplasms; Esophageal Neoplasms; Glioblastoma; Brain Neoplasms; Carcinoma, Pancreatic Ductal Details
ACT-50 ACT-50 Phase 1 Clinical Xiamen Amoytop Biotech Co Ltd Neoplasms; Carcinoma, Pancreatic Ductal Details
Pagantangentide Phase 1 Clinical Nanjing Anji Biological Technology Co Ltd, Jiangsu Aotexin Biomedical Technology Co Ltd, China Pharmaceutical University Arthritis, Rheumatoid; Rheumatic Diseases Details

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