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NS1

Brief Information

Name:Src homology phosphotyrosyl phosphatase 2
Target Synonym:Protein Tyrosine Phosphatase Non-Receptor Type 11,EC:3.1.3.48,SHP-2,PTP2C,Protein-tyrosine phosphatase 2C,PTP-2C,PTP-1D,SH-PTP3,PTPN11,Protein-Tyrosine Phosphatase 1D,SH-PTP2,Noonan Syndrome 1,EC 3.1.3.48,METCDS,SHPTP2,BPTP3,JMML,SHP2,CFC,NS1,Protein Tyro
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
NS1-Z82E9 Zika virus Biotinylated Zika virus NS1 Protein, Avitag™,His Tag
NS1-Z82E9-structure
NS1-Z82E9-sds
NS1-Z5222 Zika virus Zika virus NS1 Protein, His Tag
NS1-Z5222-structure
NS1-Z5222-sds

Synonym Name

NS1

Background

Zika virus (ZIKV) is a member of the virus family Flaviviridae and the genus Flavivirus, transmitted by daytime-active Aedes mosquitoes, such as A. aegypti and A. albopictus. Its name comes from the Zika Forest of Uganda, where the virus was first isolated in 1947. Zika virus is related to dengue, yellow fever, Japanese encephalitis, and West Nile viruses. The infection, known as Zika fever, often causes no or only mild symptoms, similar to a mild form of dengue fever. It is treated by rest. Since the 1950s, it has been known to occur within a narrow equatorial belt from Africa to Asia. As of 2016, the illness cannot be prevented by drugs or vaccines. As of February 2016, there is evidence that Zika fever in pregnant women is associated with abnormal brain development in their fetuses through mother-to-child transmission of the virus, which may result in miscarriage or microcephaly.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ERAS-601 ERAS-601 Phase 1 Clinical Erasca Inc Solid tumours Details
RMC-4630 RMC-4630; SAR-442720 Phase 2 Clinical Revolution Medicines, Sanofi Solid tumours; Neoplasm Metastasis Details
SH-3809 SH3809 Phase 1 Clinical Nanjing Sanhome Pharmaceutical Co Ltd Solid tumours Details
RLY-1971 RLY-1971 Phase 1 Clinical Relay Therapeutics Solid tumours Details
JAB-3312 JAB-3312 Phase 2 Clinical Jacobio Pharmaceuticals Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details
TNO-155 TNO-155 Phase 2 Clinical Novartis Pharma Ag Solid tumours; Squamous Cell Carcinoma of Head and Neck; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Lung Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasm Metastasis Details
BBP-398 BBP-398; IACS-13909; IACS-15509 Phase 1 Clinical Navire Pharma Inc Solid tumours Details
ET-0038 ET-0038 Phase 1 Clinical Shanghai Yituo Pharmaceutical Technology Co Ltd Solid tumours Details
JAB-3068 JAB-3068 Phase 2 Clinical Jacobio Pharmaceuticals Co Ltd Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details

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