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Your Position: Home > NS1

NS1

Brief Information

Name:Src homology phosphotyrosyl phosphatase 2
Target Synonym:Protein Tyrosine Phosphatase Non-Receptor Type 11,SHP-2,PTP2C,Protein-tyrosine phosphatase 2C,PTP-2C,PTP-1D,SH-PTP3,PTPN11,Protein-Tyrosine Phosphatase 1D,SH-PTP2,EC:3.1.3.48,Noonan Syndrome 1,EC 3.1.3.48,METCDS,SHPTP2,BPTP3,JMML,SHP2,CFC,NS1,Protein Tyrosine Phosphatase, Non-Receptor Type 11,Tyrosine-Protein Phosphatase Non-Receptor Type 11
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:18
Lastest Research Phase:Phase 3 Clinical

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ACRO Quality

Synonym Name

NS1

Background

Zika virus (ZIKV) is a member of the virus family Flaviviridae and the genus Flavivirus, transmitted by daytime-active Aedes mosquitoes, such as A. aegypti and A. albopictus. Its name comes from the Zika Forest of Uganda, where the virus was first isolated in 1947. Zika virus is related to dengue, yellow fever, Japanese encephalitis, and West Nile viruses. The infection, known as Zika fever, often causes no or only mild symptoms, similar to a mild form of dengue fever. It is treated by rest. Since the 1950s, it has been known to occur within a narrow equatorial belt from Africa to Asia. As of 2016, the illness cannot be prevented by drugs or vaccines. As of February 2016, there is evidence that Zika fever in pregnant women is associated with abnormal brain development in their fetuses through mother-to-child transmission of the virus, which may result in miscarriage or microcephaly.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
JAB-3312 JAB-3312 Phase 3 Clinical Jacobio Pharmaceuticals Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung Details
JAB-3068 JAB-3068 Phase 2 Clinical Jacobio Pharmaceuticals Co Ltd, Abbvie Inc Solid tumours; Head and Neck Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Adenoid Cystic; Esophageal Squamous Cell Carcinoma; Lymphoma; Carcinoma, Non-Small-Cell Lung Details
Vociprotafib RMC-4630; SAR-442720 Phase 2 Clinical Sanofi, Revolution Medicines Inc Solid tumours; Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
TNO-155 TNO-155 Phase 2 Clinical Novartis Pharma Ag Solid tumours; Squamous Cell Carcinoma of Head and Neck; Renal Insufficiency; Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hepatic Insufficiency; Esophageal Squamous Cell Carcinoma; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Melanoma Details
GH-21 GH 21005; GH-21; HBI-2376 Phase 2 Clinical Suzhou GenHouse pharmaceutical Co Ltd Solid tumours; Head and Neck Neoplasms; Colonic Neoplasms; Pancreatic Neoplasms; Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BR-790 BR-790 Phase 2 Clinical Jiangxi Qingfeng Pharmaceutical Industry Co Ltd Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BBP-398 IACS-15509; BBP-398; IACS-13909; BMS-986466 Phase 2 Clinical Bridgebio Pharma Inc, The University Of Texas MD Anderson Cancer Center Solid tumours; Carcinoma, Non-Small-Cell Lung Details
Migoprotafib RLY-1971; GDC-1971; RO-7517834; RG-6433 Phase 1 Clinical Relay Therapeutics Inc Solid tumours; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
A-380 A-380 Phase 1 Clinical Shandong Kelun Phaemaceutical Co Ltd, Klus Pharma Inc Neoplasms Details
RG-001 RG001; RG-001 Phase 1 Clinical Shanghai Lingji Biological Technology Co Ltd Neoplasms Details
HMPL-415S1 HMPL-415S1 Phase 1 Clinical Hutchison Medipharma Ltd Solid tumours Details
BPI-442096 Phase 1 Clinical Betta Pharmaceuticals Co Ltd Solid tumours; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
HS-10381 HS-10381 Phase 1 Clinical Jiangsu Hansoh Pharmaceutical Group Co Ltd Solid tumours Details
ET-0038 ET-0038 Phase 1 Clinical Shanghai Yituo Pharmaceutical Technology Co Ltd Solid tumours Details
PF-07284892 ARRY-558; PF-07284892 Phase 1 Clinical Pfizer Inc Solid tumours; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
ICP-189 ICP-189 Phase 1 Clinical InnoCare Pharma Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
ERAS-601 ERAS-601 Phase 1 Clinical Erasca Inc Solid tumours; Leukemia, Myeloid, Acute Details
SH-3809 SH3809 Phase 1 Clinical Nanjing Sanhome Pharmaceutical Co Ltd Solid tumours Details

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