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LOXL2 Molecule Information

Name:Lysyl oxidase homolog 2
Target Synonym:Lysyl oxidase-related protein WS9-14;Lysyl oxidase-like protein 2;Lysyl oxidase homolog 2;LOXL2;Lysyl oxidase-related protein 2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
LO2-H82E3 Human Biotinylated Human LOXL2 Protein, His,Avitag™
LO2-H525x Human Human LOXL2 Protein, Fc Tag

LOXL2 Molecule Synonym Name

Lysyl oxidase homolog 2,LOXL2

LOXL2 Molecule Background

Lysyl oxidase homolog 2 also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

LOXL2 References

LOXL2 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PAT-1251 PAT-1251 Phase Ⅰ PharmAkea Therapeutics Idiopathic pulmonary fibrosis (IPF) Details
PXS-5338 PXS-5338,PXS-5338K; PXS-5338 Phase Ⅰ Pharmaxis Hepatic fibrosis, Renal fibrosis, Pulmonary fibrosis, Non-alcoholic steatohepatitis Details
Selonsertib/Simtuzumab Phase Ⅱ Gilead Non-alcoholic steatohepatitis Details
PXS-5382 PXS-5382; PXS-5382A Phase Ⅰ Pharmaxis Renal fibrosis, Idiopathic pulmonary fibrosis (IPF), Non-alcoholic steatohepatitis Details
Simtuzumab AB-0024; GS-6624 Phase Ⅱ Gilead Hepatic fibrosis, Non-alcoholic steatohepatitis, Primary sclerosis cholangitis, Cirrhosis Details

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