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Your Position: Home > Integrin alpha V beta 5

Integrin alpha V beta 5

Brief Information

Name:Integrin alpha-V/beta-5
Target Synonym:Receptors, Vitronectin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IT5-C52W3 Cynomolgus Cynomolgus Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT5-C52W3-structure
IT5-C52W3-sds
IT5-M82W9 Mouse Biotinylated Mouse Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His,Avitag™&Tag Free
IT5-M82W9-structure
IT5-M82W9-sds
IT5-R52E3 Rat Rat Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free
IT5-R52E3-structure
IT5-R52E3-sds
IT5-H82Wa Human Biotinylated Human Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
IT5-H82Wa-structure
IT5-H82Wa-sds
IT5-H52W5 Human Human Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free
IT5-H52W5-structure
IT5-H52W5-sds
ACRO Quality

Part of Bioactivity data

IT5-R52E3-ELISA
Integrin alpha V beta 5 ELISA

Immobilized Human Vitronectin at 5 μg/mL (100 μL/well) can bind Rat ITGAV&ITGB5 Heterodimer, His Tag&Tag Free (Cat. No. IT5-R52E3) with a linear range of 0.02-0.156 μg/mL (QC tested).

Protocol
IT5-C52W3-MALS-HPLC
Integrin alpha V beta 5 MALS images

The purity of Cynomolgus Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free (Cat. No. IT5-C52W3) is more than 85% and the molecular weight of this protein is around 200-250 kDa verified by SEC-MALS.

Synonym Name

Integrin alpha V beta 5,ITGAV&ITGB5

Background

Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF  alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF  beta from latency.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Risuteganib ALG-1001; AM011; AM-011(Allegro Ophthalmics) Phase 1 Clinical Allegro Ophthalmics Llc Diabetic macular oedema; Geographic Atrophy; Diabetic Retinopathy; Macular Degeneration Details
NP-011 NP-011 Phase 1 Clinical Nexell Therapeutics Inc Myocardial Infarction Details

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