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Your Position: Home > VEGF R3

VEGF R3

Brief Information

Name:Vascular endothelial growth factor receptor 3
Target Synonym:LMPHM1,Primary Congenital Lymphedema,Fms Related Receptor Tyrosine Kinase 4,VEGF Receptor-3,Feline McDonough Sarcoma (FMS)-Like Tyrosine Kinase 4,VEGFR3,VEGFR-3,FLT4,Vascular endothelial growth factor receptor 3,Fms Related Tyrosine Kinase 4,Tyrosine-Protein Kinase Receptor FLT4,Fms-Like Tyrosine Kinase 4,FLT-4,Fms-Related Tyrosine Kinase 4,LMPH1A,FLT41,PCL,Vascular Endothelial Growth Factor Receptor-3,CHTD7
Number of Launched Drugs:12
Number of Drugs in Clinical Trials:11
Lastest Research Phase:Approved

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Part of Bioactivity data

FL4-H5251-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human VEGF R3, Fc Tag (Cat. No. FL4-H5251) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human VEGF-D, His Tag (Cat. No. VED-H5228) with an affinity constant of 19.7 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

FL4-H5251-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human VEGF-C, His Tag (Cat. No. VEC-H4225) captured on CM5 Chip via anti-His antibody can bind Human VEGF R3, Fc Tag (Cat. No. FL4-H5251) with an affinity constant of 41.1 pM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

Flt-4,FLT4,LMPH1A,PCLFLT41,VEGFR3,VEGFR-3,FLT-4,FLT-41,FLT41,PCL

Background

Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Chloropyramine Hydrochloride C9; C10; C9A; Y15; CFAK-C4; CFAK-C9; CFAK-C10; CFAK-Y15; CFAK-C9a Approved Synopen, Supralgon, Suprastin Rhinitis, Allergic; Conjunctivitis, Allergic; Asthma Details
Tivozanib AV-951; KRN-951; ASP-4130; Kil-8951 Approved Kyowa Hakko Kirin Co Ltd Fotivda United States Carcinoma, Renal Cell Aveo Pharmaceuticals Inc 2017-08-24 Carcinoma, Renal Cell Details
Fruquintinib HMPL-013 Approved Hutchison Medipharma Ltd 爱优特, Elunate Macau Colorectal Neoplasms Hutchison Huangpu Medicine (Shanghai) Co Ltd 2018-09-04 Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Rectal Neoplasms; Neoplasms; Colonic Neoplasms; Kidney Diseases; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Sarcoma; Breast Neoplasms; Colorectal Neoplasms; Hepatic Insufficiency; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc Nexavar, 多吉美 EU Thyroid Neoplasms Bayer AG 2005-12-01 Lung Neoplasms; Adrenocortical Carcinoma; Mesothelioma; Breast Neoplasms; Hepatitis B; Prostatic Neoplasms; Brain Neoplasms; Sarcoma; Pulmonary Arterial Hypertension; Medullary thyroid cancer (MTC); Hepatitis C; Thyroid Neoplasms; Leukemia, Monocytic, Acute; Lymphoma, T-Cell; Digestive System Neoplasms; Leukemia, Myeloid, Acute; Glioma; Venous Thrombosis; Facial Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Melanoma; Adenocarcinoma; Fasting; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasms; Ovarian Neoplasms; Hematopoietic stem cell transplantation (HSCT); Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Solid tumours; Kidney Neoplasms; Recurrence; Carcinoma, Renal Cell; Carcinoma; Stomach Neoplasms; Abdominal Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Liver Neoplasms; Neoplasms, Glandular and Epithelial; Kidney Diseases; Myelodysplastic Syndromes; Myeloproliferative Disorders; Thyroid Details
Pazopanib Hydrochloride GSK-786034; GW-786034B; SB-786034; GW-786034 Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Votrient, Patorma Mainland China Carcinoma, Renal Cell Novartis Pharma Schweiz Ag 2009-10-19 Urogenital Neoplasms; Prostatic Neoplasms; Osteosarcoma; Peritoneal Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Carcinoma, Small Cell; Leukemia, Myeloid, Acute; Sarcoma, Alveolar Soft Part; Fallopian Tube Neoplasms; Thyroid Neoplasms; Lung Neoplasms; Breast Neoplasms; Glioma; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Macular Degeneration; Melanoma; Neoplasm Metastasis; Carcinoma, Hepatocellular; Thyroid Cancer, Papillary; Neoplasms, Germ Cell and Embryonal; Neoplasms; Ovarian Neoplasms; Solid tumours; Chondrosarcoma; Epistaxis; Telangiectasia, Hereditary Hemorrhagic; Leiomyosarcoma; Carcinoma, Renal Cell; Hemangiosarcoma; Squamous Cell Carcinoma of Head and Neck; Thoracic Neoplasms; Head and Neck Neoplasms; Small Cell Lung Carcinoma; Glioblastoma; Pancreatic Neoplasms; Dermatofibrosarcoma; Central Nervous System Neoplasms; Lymphedema; Liposarcoma; Adenocarcinoma, Follicular; Soft Tissue Neoplasms; Sarcoma Details
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance Mainland China Gastrointestinal Stromal Tumors Bayer Pharma Ag 2012-09-27 Leukemia, Myeloid, Acute; Sarcoma; Gastrinoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bile Duct Neoplasms; Peritoneal Neoplasms; Lymphoma, Non-Hodgkin; Lung Neoplasms; Carcinoma, Adenoid Cystic; Thyroid Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Hepatocellular; Melanoma; Neoplasm Metastasis; Gastrointestinal Neoplasms; Somatostatinoma; Solid tumours; Glucagonoma; Multiple Myeloma; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Transitional Cell; Neoplasms; Glioblastoma; Colonic Neoplasms; Hemangiosarcoma; Carcinoma, Islet Cell; Insulinoma; Carcinoid Tumor; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms Details
Axitinib AG-013736; CLS-AX; AG-13736; PF-01367866 Approved Pfizer Pharmaceuticals Ltd (China) Inlyta, 英立达 Mainland China Carcinoma, Renal Cell Pfizer Europe Ma Eeig 2012-01-27 Endometriosis; Macular Degeneration; Paraganglioma; Melanoma; Carcinoma, Hepatocellular; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Thyroid Neoplasms; Colorectal Neoplasms; Hepatic Insufficiency; Sarcoma; Prostatic Neoplasms, Castration-Resistant; Carcinoma, Adenoid Cystic; Solid tumours; Multiple Myeloma; Mesothelioma; Adrenal Cortex Neoplasms; Nasopharyngeal Neoplasms; Glioblastoma; Myelodysplastic Syndromes; Skin Neoplasms; Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma; Pheochromocytoma; Carcinoid Tumor; Carcinoma, Renal Cell; Ovarian Neoplasms; Kidney Neoplasms Details
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx Japan Carcinoma, Renal Cell Takeda 2012-11-29 Thyroid Neoplasms; Adenocarcinoma, Follicular; Brain Neoplasms; Sarcoma; Neuroblastoma; Neurofibroma, Plexiform; Prostatic Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Bile Duct Neoplasms; Central Nervous System Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Glioma; Carcinoma, Neuroendocrine; Carcinoma, Hepatocellular; Neoplasms, Germ Cell and Embryonal; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Thyroid Cancer, Papillary; Meningioma; Carcinoma, Transitional Cell; Kidney Neoplasms; Ovarian germ cell tumor; Bone metastases; Carcinoma, Renal Cell; Rejection of liver transplantation; Esophageal Neoplasms; Pain; Stomach Neoplasms; Carcinoma, Merkel Cell; Glioblastoma; Seminoma; Solid tumours; Neurofibromatoses; Neoplasms; Salivary Gland Neoplasms; Carcinoma, Papillary; Skin Neoplasms; Kidney Diseases; Neuroendocrine Tumors; Adrenocortical Carcinoma; Prostatic Neoplasms, Castration-Resistant; Multiple Myeloma Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef EU systemic sclerosis-associated interstitial lung disease Boehringer Ingelheim International Gmbh 2014-10-15 Genital Neoplasms, Female; Sarcoma; Prostatic Neoplasms; systemic sclerosis-associated interstitial lung disease; Breast Neoplasms; Adenocarcinoma, Clear Cell; Peritoneal Neoplasms; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Oligodendroglioma; Bronchitis; Silicosis; Gliosarcoma; Appendiceal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Idiopathic Pulmonary Fibrosis; Head and Neck Neoplasms; Telangiectasia, Hereditary Hemorrhagic; Bronchiolitis Obliterans; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Rejection of lung transplantation; Carcinoma, Renal Cell; Scleroderma, Systemic; Ovarian Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Glioblastoma; Small Cell Lung Carcinoma; Pulmonary Fibrosis; Lung Diseases, Interstitial; Multiple Myeloma; Asbestosis Details
Lenvatinib Mesylate ER-203492-00; E-7080; MK-7902 Approved Eisai Co Ltd Lenvima, Lenvima/Kisplyx, 乐卫玛, Kisplyx Japan Carcinoma, Renal Cell Merck Sharp & Dohme Corp 2015-02-13 Carcinoma, Adenoid Cystic; Thrombosis; Thyroid Cancer, Papillary; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Melanoma; Esophageal Squamous Cell Carcinoma; Endometrial Neoplasms; Lymphoma; Thyroid Neoplasms; Colorectal Neoplasms; Hepatic Insufficiency; Cholangiocarcinoma; Breast Neoplasms; Sarcoma; Neuroendocrine Tumors; Solid tumours; Urinary Bladder Neoplasms; Adenocarcinoma, Follicular; Liver Diseases; Small Cell Lung Carcinoma; Neoplasms; Kidney Diseases; Thyroid Carcinoma, Anaplastic; Adenocarcinoma of Lung; Rejection of liver transplantation; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Renal Insufficiency; Carcinoma, Renal Cell; Liver Neoplasms; Biliary Tract Neoplasms Details
Anlotinib Dihydrochloride AL-3818 Approved Advenchen Laboratories, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 福可维 Mainland China Thyroid Neoplasms Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2018-05-08 Thyroid Neoplasms; Nasopharyngeal Carcinoma; Lymphoma, Extranodal NK-T-Cell; Cholangiocarcinoma; Bile Duct Diseases; Bone Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Gastrointestinal Stromal Tumors; Urologic Neoplasms; Sarcoma, Alveolar Soft Part; Endometrial Neoplasms; Gallbladder Neoplasms; Esophageal Squamous Cell Carcinoma; Medullary thyroid cancer (MTC); Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Glioma; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma; Carcinoma, Hepatocellular; Esophageal Diseases; Paraganglioma; Adenocarcinoma; Osteoma; Gastrointestinal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Leiomyosarcoma; Head and Neck Neoplasms; Biliary Tract Neoplasms; Solid tumours; Chondrosarcoma; Liver Neoplasms; Esophageal Neoplasms; Thoracic Neoplasms; Genital Diseases, Female; Stomach Neoplasms; Pheochromocytoma; Digestive System Diseases; Gastrointestinal Diseases; Ovarian Neoplasms; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Tripl Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; PNU-290940AD; PHA-290940AD; GB-102; PNU-290940; SU-011248-L-malate salt Approved Pfizer Pharmaceuticals Ltd (China) 索坦, Sutent Japan Pancreatic neuroendocrine tumors (pNET) Pfizer Inc 2006-01-26 Diabetic macular oedema; Thyroid Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Peritoneal Neoplasms; Astrocytoma; Thymus Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Thymoma; Neurofibroma, Plexiform; Cholangiocarcinoma; Medullary thyroid cancer (MTC); Brain Neoplasms; Urethral Neoplasms; Prostatic Neoplasms; Sarcoma; Breast Neoplasms; Adrenocortical Carcinoma; Adenocarcinoma; Paraganglioma; Melanoma; Thyroid Cancer, Papillary; Retinal Vein Occlusion; Meningioma; von Hippel-Lindau Disease; Neoplasm Metastasis; Macular Degeneration; Carcinoma, Hepatocellular; Adenocarcinoma, Follicular; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Neoplasms, Gonadal Tissue; Nervous System Neoplasms; Germinoma; Brain metastases; Hemangiopericytoma; Urogenital Neoplasms; Hemangioblastoma; Glioblastoma; Pheochromocytoma; Pelvic Neoplasms; Thoracic Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Carcinoma, Islet Cell; Histiocytom Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Sorafenib Tosylate/MG-K10 MG-D-1609 Phase 2 Clinical Metagone Biotech Solid tumours Details
R-1530 RG1530; R-1530; RG-1530 F. Hoffmann-La Roche Ltd Details
IMC-3C5 IMC-3C5; LY-3022856 Circadian Technologies, Licentia, Ludwig Institute For Cancer Research Details
Motesanib Diphosphate AMG-706 Amgen Inc Details
BMS-690514 BMS-690514 Bristol-Myers Squibb Company Details
EVT-801 EVT-801 Sanofi Sa (Sanofi Ag) Details
Vatalanib succinate ZK-222584; CGP-79787D; PTK-787 Novartis Pharma Ag Details
Roniciclib 1-SI-2; BAY-1000394 Bayer AG Details
Cediranib AZD2171; AZD-2171; NSC-732208 Astrazeneca Plc Details
Glesatinib MG-90265; MGCD-265; MG-90265X; 7Q29OXD98N; MG-90265H9; MG-90265gly Mirati Therapeutics Details
Telatinib EOC-315; BAY-57-9352 Phase 2 Clinical Bayer AG Solid tumours; Stomach Neoplasms Details
ODM-203 ODM-203 Orion Corp Details
Veglin AS-3; VEGF-AS University Of Southern California Details
Sorafenib/MG-005 MGD-1509; MG-D-1509 Metagone Biotech, Tri-Service General Hospital Details
Tafetinib Malate SIM-0702; SIM-1005; SIM-010603 Phase 1 Clinical Jiangsu Simcere Pharmaceutical Co Ltd, Nanjing Yoko Biomedical Co Ltd, Jilin Boda Pharmaceutical Co Ltd Neoplasms Details
Famitinib Malate SHR-1020 Phase 3 Clinical Jiangsu Hengrui Medicine Co Ltd Cholangiocarcinoma; Neoplasm Metastasis; Gastrointestinal Neoplasms; Adenocarcinoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Esophageal Squamous Cell Carcinoma; Thyroid Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Urologic Neoplasms; Genital Neoplasms, Female; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Ovarian Neoplasms; Nasopharyngeal Carcinoma; Breast Neoplasms; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Pancreatic neuroendocrine tumors (pNET); Neoplasms; Nasopharyngeal Neoplasms; Idiopathic Pulmonary Fibrosis; Carcinoma, Renal Cell; Solid tumours; Biliary Tract Neoplasms Details
Lucitanib AL-3810; CO-3810; S-80881 Phase 3 Clinical Advenchen Laboratories Nanjing Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Nasopharyngeal Carcinoma; Breast Neoplasms; Colorectal Neoplasms; Genital Neoplasms, Female; Thymus Neoplasms; Carcinoma, Small Cell; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Sitravatinib IND-155305; MG-516; MG-91516; MGCD-516 Phase 3 Clinical Mirati Therapeutics Ureteral Neoplasms; Melanoma; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Lung Neoplasms; Mouth Neoplasms; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Hepatic Insufficiency; Solid tumours; Breast Neoplasms; Liposarcoma; Lung Diseases; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Carcinoma, Renal Cell; Carcinoma; Squamous Cell Carcinoma of Head and Neck; Biliary Tract Neoplasms Details

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