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Your Position: Home > IL-12B & IL-12A

IL-12B & IL-12A

Brief Information

Target Synonym:Interleukin-12
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Approved

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Part of Bioactivity data

IL2-H4210-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) stimulates the proliferation of PHA-P activated PBMC. The ED50 for this effect is 0.05 ng/mL (Routinely tested).


Human IL-12 R beta 1, Fc Tag (Cat. No. ILB-H5255) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 2.06 nM as determined in a SPR assay (Biacore T200) (Routinely tested).


Loaded Anti-IL23A & IL12B MAb (P40 domain) on Protein A Biosensor, can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 1.07 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL-12B & IL-12A Molecule Synonym Name


IL-12B & IL-12A Molecule Background

Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.

IL-12B & IL-12A References

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 Waldenstrom Macroglobulinemia; Sarcoma; Prostatic Neoplasms; Arachnoiditis; Cholangitis, Sclerosing; Gastrointestinal Hemorrhage; Osteosarcoma; Pancreatitis, Chronic; Retinoblastoma; Sarcoma, Ewing; Lymphoma, Mantle-Cell; Prostatitis; Colitis, Ulcerative; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Erythema Nodosum; Leprosy, Lepromatous; Endometrial Neoplasms; Appendiceal Neoplasms; Pelvic Pain; Angiodysplasia; Glioma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular; Amyotrophic Lateral Sclerosis; Vascular Malformations; Crohn Disease; Precancerous Conditions; Mycobacterium avium-intracellulare Infection; Idiopathic Pulmonary Fibrosis; Leukemia; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Liver Neoplasms; Cough; Telangiectasia, Hereditary Hemorrhagic; Mycobacterium Infections; Rhabdomyosarcoma; Arteriovenous Malformations; Inflammatory Bowel Diseases; Stomatitis, Aphthous; Gastric Antral Vascular Ectasia; Spondylitis, Ankylosing; Myelodysplastic Syndromes; HIV Infections; Coronavirus Dise Details
Ustekinumab CNTO-1275; C-340; AVT-04 Approved Janssen Global Services Llc Stelara Mainland China Plaque psoriasis Janssen-Cilag International Nv 2009-01-15 Multiple Sclerosis; Dermatitis, Atopic; Plaque psoriasis; Crohn Disease; Hidradenitis Suppurativa; Colitis, Ulcerative; Pemphigoid, Bullous; Arthritis, Psoriatic; Takayasu Arteritis; Lupus Erythematosus, Systemic; Psoriasis; Diabetes Mellitus, Type 1; Arthritis, Juvenile; Sjogren's Syndrome; Ichthyosis; Pouchitis; Spondylitis, Ankylosing; Inflammatory Bowel Diseases; Dermatomyositis; Polymyositis; Liver Cirrhosis, Biliary; Solid tumours Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ustekinumab Biosimilar (NeuClone/Serum Institute of India) Phase 1 Clinical Neuclone, Serum Institute Of India Autoimmune Diseases Details
EGFR IL12 CART Phase 1 Clinical Shenzhen Prekin Biopharmaceutical Co Ltd Colorectal Neoplasms Details
Ustekinumab biosimilar(CSPC Pharma) Phase 1 Clinical Jushi Biopharmaceutical Co Ltd Plaque psoriasis Details
VG-201 VG-201 Phase 1 Clinical ViroGin Biotech Ltd Esophageal Neoplasms; Stomach Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
ABOD-2011 ABOD-2011 Phase 1 Clinical Cancer Hospital Of Chinese Academy Of Medical Sciences Solid tumours Details
Ustekinumab biosimilar(DM Bio) DA-3115; DMB-3115 Meiji Seika Pharma Co Ltd, Dong-A Pharmaceutical Co Ltd Details
Recombinant Human IL12/15-PDL1B Herpes Simplex Type I Oncolytic Virus(CNBG) VG-161 Phase 2 Clinical Liver Neoplasms; Solid tumours; Biliary Tract Neoplasms; Esophageal Neoplasms; Neoplasms Details
Ustekinumab biosimilar(Amgen) ABP-654 Amgen Inc Details
Ustekinumab biosimilar (BioFactura) BFI-751 BioFactura Australia Pty Ltd Details
MEDI-1191 MEDI-1191; MEDI1191 Moderna Inc Details
Mycobacterium cell wall-DNA Complex (ProMetic Life Sciences) EN-3348 Prometic Life Sciences Details
GX-51 GX-051 Pocastem, Genexine Inc Details
Briakinumab J-695; ABT-874; LU-415977; A-796874.0; BSF-415977; WAY-165772 Cambridge Antibody Technology Details
Interleukin-12 gene therapy (OncoSec Medical) pIL-12; DNA IL-12 Inovio Details
IL-12 gene therapy (Methodist Hospital) Methodist Hospital System Details
ONCR-177 ONCR-177 Oncorus Details
NSC-733972 M-032; M032-H SV-1; NSC-733972 University Of Alabama At Birmingham Details
MEDI-9253 Phase 1 Clinical Astrazeneca Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
DF-6002 DF-6002 Phase 2 Clinical Dragonfly Therapeutics Solid tumours; Neoplasms Details
NHS-IL-12 M-9241; MSB-0010360 National Cancer Institute, Emd Serono Inc, Merck Serono Details
Rocakinogene sifuplasmid INO-9012 Phase 2 Clinical Inovio Neoplasms, Glandular and Epithelial; Precancerous Conditions; Carcinoma, Hepatocellular; Vulvar Diseases; Lung Neoplasms; Hepatitis C; Colorectal Neoplasms; Squamous Intraepithelial Lesions of the Cervix; Lymphoma, Mantle-Cell; Breast Neoplasms; Prostatic Neoplasms; Carcinoma, Transitional Cell; Hepatitis, Chronic; Papillomavirus Infections; Pancreatic Neoplasms; Urogenital Abnormalities; Glioblastoma; Esophageal Neoplasms; Stomach Neoplasms; HIV Infections; Ovarian Neoplasms; Head and Neck Neoplasms; Liver Neoplasms Details
Ustekinumab biosimilar(Formycon) FYB-202 Phase 3 Clinical Formycon Psoriasis Details
Apilimod mesilate STA-5326-mesylate; LAM-002; LAM-002A; STA-5326; AIT-101 Phase 2 Clinical Lam, Synta Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Lymphoma, Non-Hodgkin; Crohn Disease; Amyotrophic Lateral Sclerosis; Leukemia, Lymphocytic, Chronic, B-Cell Details
Ustekinumab biosimilar (Bio-Thera ) BAT-2206 Phase 3 Clinical Bio-Thera Solutions Ltd Autoimmune Diseases; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis Details
Ustekinumab Biosimilar (qyuns) QX-001-S; HDM-3001; QX-001S Phase 3 Clinical Qyuns Therapeutics Co Ltd Psoriasis; Plaque psoriasis Details
T3011 MVR-T3011; T3011; MVR-T3011 IT; MVR-T3011 IV Phase 2 Clinical Immvira Co Ltd Liver Neoplasms; Solid tumours; Head and Neck Neoplasms; Esophageal Neoplasms; Mesothelioma; Breast Neoplasms; Lung Neoplasms; Lymphoma; Neoplasm Metastasis; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Lisofylline BL-194; CT-1501R; A-802710 Phase 3 Clinical Cti Biopharma Corp Diabetes Mellitus, Type 1; Rejection of organ transplantation Details
JCXH-211 JCXH-211 Phase 1 Clinical Jiachen Xihai(Hangzhou)Biotechnology Co Ltd Solid tumours Details
INO-9112 INO-9112 Phase 1 Clinical Inovio Pharmaceuticals Hepatitis B; Coronavirus Infections Details
MVR-C5252 C-5252; MVR-C5252 Phase 1 Clinical Immvira Co Ltd Solid tumours; Glioblastoma; Ganglioglioma; Brain Neoplasms Details

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