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Your Position: Home > IL-12B & IL-12A

IL-12B & IL-12A

IL-12B & IL-12A Molecule Information

Name:Interleukin-12
Target Synonym:Interleukin-12
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:16
Lastest Research Phase:Approved

IL-12B & IL-12A Protein Product ListCompare or Buy

IL-12B & IL-12A Part of Bioactivity data

IL2-H4210-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) stimulates the proliferation of PHA-P activated PBMC. The ED50 for this effect is 0.05 ng/mL (Routinely tested).

IL2-H4210-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-12 R beta 1, Fc Tag (Cat. No. ILB-H5255) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 2.06 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

IL2-H4210-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Anti-IL23A & IL12B MAb (P40 domain) on Protein A Biosensor, can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 1.07 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL-12B & IL-12A Molecule Synonym Name

IL12,p70,Interleukin-12

IL-12B & IL-12A Molecule Background

Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.

IL-12B & IL-12A References

IL-12B & IL-12A Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Thalidomide K-17; NSC-66847; NSC-527179 Approved Celgene Corp Thaled, Synovir, Talizer, Thalomid, Thalidomide Celgene, Thalidomide Pharmion Japan Leprosy, Lepromatous s:23:"Fujimoto Pharmaceutical"; 1982-01-01 HIV Infections; Spondylitis, Ankylosing; Myelodysplastic Syndromes; Multiple Myeloma; Erythema Nodosum; HIV Wasting Syndrome; Leprosy, Lepromatous; Carcinoma, Hepatocellular Details
Ustekinumab C-340; CNTO-1275 Approved Janssen Global Services Llc Stelara Mainland China Plaque psoriasis s:30:"Janssen-Cilag International Nv"; 2009-09-25 Liver Cirrhosis, Biliary; Polymyositis; Solid tumours; Inflammatory Bowel Diseases; Dermatomyositis; Multiple Sclerosis; Lupus Erythematosus, Systemic; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Plaque psoriasis; Crohn Disease; Dermatitis, Atopic Details

IL-12B & IL-12A Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ustekinumab Biosimilar (NeuClone/Serum Institute of India) Phase 1 Clinical Neuclone, Serum Institute Of India Autoimmune Diseases Details
IL-12 gene therapy (Methodist Hospital) Phase 2 Clinical Methodist Hospital System Triple Negative Breast Neoplasms Details
Interleukin-12 gene therapy (OncoSec Medical) pIL-12; DNA IL-12 Phase 2 Clinical Inovio Breast Neoplasms; Melanoma; Mycosis Fungoides; Carcinoma, Hepatocellular; Lymphoma, T-Cell, Cutaneous; Lung Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Lymphoma, Mantle-Cell; Ovarian Neoplasms; Hepatitis B; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Merkel Cell; Stomach Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms Details
Ustekinumab biosimilar(Formycon) FYB-202 Phase 3 Clinical Formycon Immune System Diseases; Psoriasis Details
Lisofylline BL-194; CT-1501R; A-802710 Phase 3 Clinical Cti Biopharma Corp Diabetes Mellitus, Type 1; Rejection of organ transplantation Details
NHS-IL-12 M-9241; MSB-0010360 Phase 2 Clinical Emd Serono Inc, Merck Serono, National Cancer Institute Neoplasms Details
ONCR-177 ONCR-177 Phase 1 Clinical Oncorus Solid tumours; Liver Neoplasms; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Skin Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Melanoma Details
Recombinant human anti-IL12 antibody (Bio-Thera Solutions) BAT-2206 Phase 3 Clinical Bio-Thera Solutions Ltd Autoimmune Diseases; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis Details
INO-9012/Human papillomavirus vaccine (VGX Pharmaceuticals) INO-3112; INO-9012/VGX-3100; VGX-3100/INO-9012 Phase 2 Clinical University Of Pennsylvania Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms Details
Ustekinumab Biosimilar (qyuns) QX-001S; QX-001-S Phase 1 Clinical Jiangsu Quanxin Biomedical Co Ltd Psoriasis; Plaque psoriasis Details
Ustekinumab biosimilar(DM Bio) DA-3115; DMB-3115 Phase 3 Clinical Meiji Seika Pharma Co Ltd, Dong-A Pharmaceutical Co Ltd Psoriasis Details
AK101 AK-101 Phase 2 Clinical Zhongshan Akeso Biopharma Co Ltd Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis Details
T3011疱疹病毒(深圳市亦诺微医药) Phase 2 Clinical Shenzhen Yinuowei Pharmaceutical Technology Co Ltd Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Skin Neoplasms; Soft Tissue Neoplasms; Breast Neoplasms; Sarcoma; Lung Neoplasms; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Apilimod mesilate LAM-002; LAM-002A; STA-5326; STA-5326-mesylate Phase 2 Clinical Lam, Synta Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Psoriasis; Lymphoma, Non-Hodgkin; Crohn Disease; Immunologic Deficiency Syndromes Details

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