IL-12B & IL-12A

IL-12B & IL-12A Protein Product ListCompare or Buy

Product> Filter Results

By Product Status:

• Launched (1)

By Product Category:

• Protein (1)

By Species:

• Human (1)

By Tag:

• His Tag & Flag Tag (1)

By Conjugate:

• Unconjugated (1)

Cat. No.	Species	Product Description	Structure	Purity	Feature
IL2-H4210	Human	Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag

IL-12B & IL-12A Part of Bioactivity data

IL2-H4210-Cell-based assay

Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) stimulates the proliferation of PHA-P activated PBMC. The ED50 for this effect is 0.05 ng/mL (Routinely tested).

Protocol

IL2-H4210-SPR

Human IL-12 R beta 1, Fc Tag (Cat. No. ILB-H5255) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 2.06 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

IL2-H4210-BLI

Loaded Anti-IL23A & IL12B MAb (P40 domain) on Protein A Biosensor, can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 1.07 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

hat is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-¦Ã and TNF-¦Á from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-¦Ã. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.