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Your Position: Home > IL-12B & IL-12A

IL-12B & IL-12A

Brief Information

Target Synonym:Interleukin-12
Number of Launched Drugs:4
Number of Drugs in Clinical Trials:43
Lastest Research Phase:Approved

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Part of Bioactivity data

IL2-H5210-Cell-based assay
 IL-12B & IL-12A CELL

Human IL-12 Protein, premium grade (Cat. No. IL2-H5210) stimulates secretion of IFN-γ by NK-92 human natural killer lymphoma cells. The specific activity of Human IL-12 Protein, premium grade is > 1.00ⅹ10^7 IU/mg, which is calibrated against human IL-12 WHO International Standard (NIBSC code: 95/544) (QC tested).

IL2-H4210-Cell-based assay
 IL-12B & IL-12A CELL

Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) stimulates the proliferation of PHA-P activated PBMC. The ED50 for this effect is 0.05 ng/mL (Routinely tested).

 IL-12B & IL-12A SPR

Human IL-12 R beta 1, Fc Tag (Cat. No. ILB-H5255) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 2.06 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

 IL-12B & IL-12A BLI

Loaded Biotinylated Human IL-12 R beta 1, Fc,Avitag (Cat. No. ILB-H82F7) on SA Biosensor, can bind Human IL-12 Protein, premium grade (Cat. No. IL2-H5210) with an affinity constant of 2.6 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL-12B & IL-12A Molecule Synonym Name


IL-12B & IL-12A Molecule Background

Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.

IL-12B & IL-12A References

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ustekinumab CNTO-1275; C-340 Approved Johnson & Johnson Innovative Medicine Stelara, 喜达诺 United States Plaque psoriasis Janssen Biotech Inc 2009-09-25 Arthritis, Juvenile; Crohn Disease; Dermatitis, Atopic; Plaque psoriasis; Hidradenitis Suppurativa; Uveitis; Common Variable Immunodeficiency; Colitis, Ulcerative; Arthritis, Psoriatic; Takayasu Arteritis; Psoriasis; Lupus Erythematosus, Systemic; Liver Cirrhosis, Biliary; Multiple Sclerosis; Sjogren's Syndrome; Pouchitis; Ichthyosis; Inflammatory Bowel Diseases; Type I Leukocyte Adhesion Defect; Dermatomyositis; Non-radiographic axial spondyloarthritis; Diabetes Mellitus, Type 1; Polymyositis Details
Ustekinumab biosimilar (Alvotech) AVT04; AVT-04 Approved Alvotech hf Jamteki, Uzpruvo, SELARSDI™ Japan Psoriasis Fuji Pharma Co Ltd 2023-09-25 Psoriasis; Arthritis, Psoriatic; Plaque psoriasis; Crohn Disease Details
Ustekinumab biosimilar(Amgen) ABP-654 Approved Amgen Inc Wezlana, WEZLANA United States Crohn Disease; Plaque psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative Amgen Inc 2023-10-31 Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02; FPF-300; FPF300 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Mainland China Leprosy, Lepromatous; Multiple Myeloma Changzhou Pharmaceutical Factory 1982-01-01 HIV Wasting Syndrome; Angiodysplasia; Primary Myelofibrosis; Neuroectodermal Tumors, Primitive; Prostatitis; Colorectal Neoplasms; Osteosarcoma; Lymphoma, Mantle-Cell; Sarcoma, Ewing; Retinoblastoma; Erythema Nodosum; Drug Resistant Epilepsy; Xerostomia; Sarcoma; Pancreatitis, Chronic; Adenocarcinoma, Clear Cell; Lymphoma, Follicular; Arachnoiditis; Carcinoma, Adenosquamous; Gastrointestinal Hemorrhage; Cholangitis, Sclerosing; Prostatic Neoplasms; Pelvic Pain; Neoplasm Metastasis; Stomatitis; Burning Mouth Syndrome; Mycobacterium avium-intracellulare Infection; Amyotrophic Lateral Sclerosis; Melanoma; Myelodysplastic-Myeloproliferative Diseases; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell; Vascular Malformations; Tuberculosis; Appendiceal Neoplasms; Lymphoma, Non-Hodgkin; Uterine Neoplasms; Anemia, Sideroblastic; Glioma; Leprosy, Lepromatous; Endometrial Neoplasms; Lung Neoplasms; Waldenstrom Macroglobulinemia; Kidney Neoplasms; Thalassemia; Carcinoid Tumor; Lupus Erythematosus, Discoid Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ustekinumab biosimilar (Bio-Thera ) BAT-2206 Phase 3 Clinical Bio-Thera Solutions Ltd Autoimmune Diseases; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Plaque psoriasis; Crohn Disease Details
Ustekinumab biosimilar(Formycon) FYB-202 Phase 3 Clinical Formycon Psoriasis Details
Lisofylline BL-194; CT-1501R; A-802710 Phase 3 Clinical Cti Biopharma Corp Diabetes Mellitus, Type 1; Rejection of organ transplantation Details
Ustekinumab Biosimilar (qyuns) QX-001-S; HDM-3001; QX-001S Phase 3 Clinical Qyuns Therapeutics Co Ltd Psoriasis; Plaque psoriasis Details
Ustekinumab Biosimilar(Celltrion) CT-P43 Phase 3 Clinical Celltrion Inc Psoriasis Details
Ustekinumab biosimilar(Biocon) Phase 3 Clinical Biocon Biologics Ltd Psoriasis Details
Ustekinumab biosimilar(CSPC Pharma) SYSA-1902 Phase 3 Clinical Jushi Biopharmaceutical Co Ltd Psoriasis; Plaque psoriasis Details
Apilimod mesilate AIT-101; STA-5326-mesylate; LAM-002; STA-5326; LAM-002A Phase 2 Clinical Synta Pharmaceuticals Corp, Lam Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Common Variable Immunodeficiency; Crohn Disease; Amyotrophic Lateral Sclerosis Details
NSC-733972 M-032; M032-H SV-1; NSC-733972 Phase 2 Clinical University Of Alabama At Birmingham Glioblastoma; Gliosarcoma; Astrocytoma Details
Tavokinogene telseplasmid (OncoSec Medical) pIL-12; DNA IL-12 Phase 2 Clinical Inovio Pharmaceuticals Inc Triple Negative Breast Neoplasms; Melanoma; Carcinoma, Hepatocellular; Mycosis Fungoides; Lung Neoplasms; Lymphoma, T-Cell, Cutaneous; Colorectal Neoplasms; Breast Neoplasms; Hepatitis B; Prostatic Neoplasms; Small Cell Lung Carcinoma; Hemorrhagic Fever, Ebola; Pancreatic Neoplasms; Neoplasms; Carcinoma, Merkel Cell; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; HIV Infections; Head and Neck Neoplasms; Ovarian Neoplasms Details
INO-9012/Human papillomavirus vaccine INO-3112; INO-9012/VGX-3100; VGX-3100/INO-9012 Phase 2 Clinical University Of Pennsylvania, Astrazeneca Plc, Inovio Pharmaceuticals Inc Squamous Cell Carcinoma of Head and Neck; Anus Neoplasms; Vaginal Neoplasms; Papillomavirus Infections; Neoplasms; Carcinoma, Transitional Cell; Vulvar Neoplasms; Oropharyngeal Neoplasms; Penile Neoplasms; Uterine Cervical Neoplasms Details
T-3011 T-3 (ImmVira Pharma); MVR-T3011; T3011; MVR-T3011 IT; MVR-T3011 IV; B015; B-015 Phase 2 Clinical Immvira Co Ltd Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Squamous Cell; Lymphoma; Endometrial Neoplasms; Lung Neoplasms; Colorectal Neoplasms; Sarcoma; Liver Neoplasms; Ascites; Mesothelioma; Small Cell Lung Carcinoma; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Head and Neck Neoplasms; Solid tumours; Ovarian Neoplasms Details
PDS-0301 M-9241; MSB-0010360; MSB0010360; PDS-0301 Phase 2 Clinical Emd Serono Inc, Merck Serono, National Cancer Institute Prostatic Neoplasms; Sarcoma, Kaposi; Uterine Cervical Neoplasms; Urogenital Neoplasms; Bile Duct Neoplasms; Colorectal Neoplasms; Oropharyngeal Neoplasms; Cholangiocarcinoma; Vulvar Neoplasms; Intestinal Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pancreatic Neoplasms; Papillomavirus Infections; Rectal Neoplasms; Carcinoma; Anus Neoplasms Details
STX-001 STX-001 Phase 2 Clinical Massachusetts Institute Of Technology Solid tumours Details
DF-6002 DF-6002 Phase 2 Clinical Dragonfly Therapeutics Llc Solid tumours; Neoplasms Details
Recombinant Human nsIL12 Oncolytic Adenovirus (Beijing Haute Biotechnology) BioTTT-001; BioTTT001 Phase 2 Clinical Beijing Bio-Targeting Therapeutics Technology Co Ltd Solid tumours; Stomach Neoplasms; Neoplasms; Colorectal Neoplasms Details
Recombinant Human IL12/15-PDL1B Herpes Simplex Type I Oncolytic Virus(CNBG) VG-161 Phase 2 Clinical Cnbg-Virogin Biotech (Shanghai) Ltd Solid tumours; Liver Neoplasms; Biliary Tract Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Pancreatic Neoplasms; Sarcoma; Cholangiocarcinoma; Carcinoma, Hepatocellular Details
Rocakinogene sifuplasmid INO-9012 Phase 2 Clinical Inovio Pharmaceuticals Inc Urogenital Abnormalities; Carcinoma, Hepatocellular; Precancerous Conditions; Lung Neoplasms; Vulvar Diseases; Hepatitis C; Colorectal Neoplasms; Squamous Intraepithelial Lesions of the Cervix; Breast Neoplasms; Prostatic Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Carcinoma, Transitional Cell; Liver Neoplasms; Neoplasms, Glandular and Epithelial; Papillomavirus Infections; Pancreatic Neoplasms; Glioblastoma; Esophageal Neoplasms; Stomach Neoplasms; Hemorrhagic Fever, Ebola; Hepatitis, Chronic; Head and Neck Neoplasms; HIV Infections; Ovarian Neoplasms Details
Veledimex INXN-1001; AD-1001 Phase 1 Clinical Ziopharm Oncology Inc Glioblastoma; Brain Neoplasms; Breast Neoplasms; Astrocytoma; Diffuse Intrinsic Pontine Glioma; Melanoma Details
XTX-301 XTX-301 Phase 1 Clinical Solid tumours; Neoplasms Details
VG-201 VG-201 Phase 1 Clinical ViroGin Biotech Ltd Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
VG-203 VG-203; VG2062; VG-2062 Phase 1 Clinical ViroGin Biotech Ltd, Shanghai Funuojian Biotechnology Co Ltd, Virogin Biotech (Shenzhen) Ltd, Fenojian Biotechnology (Nantong) Co Ltd Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Breast Neoplasms Details
MVR-C5252 C-5252; MVR-C5252 Phase 1 Clinical Immvira Co Ltd Solid tumours; Ganglioglioma; Glioblastoma; Brain Neoplasms; Glioma Details
WTX-330 WTX-330 Phase 1 Clinical Werewolf Therapeutics Inc Solid tumours; Neoplasms; Lymphoma, Non-Hodgkin Details
WTX-124 WTX-124 Phase 1 Clinical Werewolf Therapeutics Inc Solid tumours; Neoplasm Metastasis Details
IL-12 DNA(NIAID) Phase 1 Clinical National Institute Of Allergy And Infectious Diseases (Niaid) HIV Infections Details
SW-0715 SW-0715 Phase 1 Clinical Stemirna Therapeutics Solid tumours Details
KGX-101 KGX-101; KGX101; KGX-101(IL-12-Fc融合蛋白); KGX-101(改造优化的细胞因子IL12前药分子) Phase 1 Clinical Shanghai KangaBio Co Ltd Solid tumours; Neoplasms Details
Ustekinumab Biosimilar (NeuClone/Serum Institute of India) Phase 1 Clinical Neuclone, Serum Institute Of India Ltd Autoimmune Diseases Details
TG-6050 TG-6050 Phase 1 Clinical Transgene Sa Carcinoma, Non-Small-Cell Lung Details
Ustekinumab biosimilar(Rani Therapeutics) RT-111 Phase 1 Clinical Rani Therapeutics Llc Psoriasis Details
ABOD-2011 ABOD-2011 Phase 1 Clinical Cancer Hospital Of Chinese Academy Of Medical Sciences Solid tumours Details
JCXH-211 JCXH-211 Phase 1 Clinical Jiachen Xihai(Hangzhou)Biotechnology Co Ltd Solid tumours; Skin Neoplasms Details
EGFR IL12 CART Phase 1 Clinical Shenzhen Prekin Biopharmaceutical Co Ltd Colorectal Neoplasms Details
XmAb-662 XmAb-662 Phase 1 Clinical Xencor Inc Solid tumours; Neoplasms Details
MEDI-1191 MEDI-1191; MEDI1191 Phase 1 Clinical Moderna Inc Solid tumours; Neoplasms Details
Ustekinumab biosimilar (BioFactura) BFI-751 Phase 1 Clinical BioFactura Australia Pty Ltd Psoriasis Details
MEDI-9253 Phase 1 Clinical Astrazeneca Plc Solid tumours; Neoplasms Details
INXN-2001 Ad-IL-12; ZIN-ATI-001; Ad-RTS-hIL-12; Ad-RTS-mIL-12; INXN-2001; Ad-RTS-IL-12; INXN-2001 (Ad-RTS-IL-12) Phase 1 Clinical Ziopharm Oncology Inc Glioblastoma; Breast Neoplasms; Brain Neoplasms; Diffuse Intrinsic Pontine Glioma; Astrocytoma; Melanoma Details

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