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M-CSF

Brief Information

Name:Macrophage Colony Stimulating Factor 1
Target Synonym:M-CSF,Macrophage colony-stimulating factor 1,CSF-1,CSF1,Colony Stimulating Factor 1,Colony Stimulating Factor 1 (Macrophage),Macrophage Colony Stimulating Factor 1,Lanimostim,MCSF,Macrophage Colony-Stimulating Factor,MGC31930
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
MCF-H82E6 Human Biotinylated Human M-CSF / CSF-1 Protein, His,Avitag™
MCF-H82E6-structure
MCF-H82E6-sds
MCF-H82E6-elisa_1
MCF-H82E6-elisa_2
MCF-H5247 Human Human M-CSF / CSF-1 Protein, His Tag
MCF-H5247-structure
MCF-H5247-sds
MCF-H5247-elisa_1
MCF-H5247-elisa_2

Part of Bioactivity data

MCF-H82E6-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) stimulates proliferation of RAW264.7 cells. The EC50 for this effect is 6.20-7.15 ng/mL (Routinely tested).

MCF-H5247-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human M-CSF, His Tag (Cat. No. MCF-H5247) stimulates proliferation of RAW264.7 cells. The EC50 for this effect is 4.40-5.27 ng/mL (Routinely tested).

MCF-H82E6-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

MCF-H5247-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human M-CSF, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R, Fc Tag, low endotoxin (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

M-CSF,CSF-1,Lanimostim

Background

The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 receptor. Macrophage colony-stimulating factor has been shown to interact with PIK3R2. M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. Locally produced M-CSF in the vessel wall contributes to the development and progression of atherosclerosis.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PD-360324 PD-360324; PD-0360324 Phase 2 Clinical Pfizer Pharmaceuticals Ltd (China) Neoplasms; Lupus Erythematosus, Cutaneous; Sarcoidosis, Pulmonary Details
Lacnotuzumab MCS-110 Phase 2 Clinical Novartis Pharma Ag Giant Cell Tumor of Tendon Sheath; Bone metastases; Synovitis, Pigmented Villonodular; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Giant Cell Tumors; Breast Neoplasms; Prostatic Neoplasms; Endometrial Neoplasms; Melanoma Details

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