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M-CSF Molecule Information

Name:Macrophage Colony Stimulating Factor 1
Target Synonym:CSF-1;M-CSF;MCSF;Processed macrophage colony-stimulating factor 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase ?

M-CSF Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
MCF-H82E6 Human Biotinylated Human M-CSF / CSF-1 Protein, His,Avitag™
MCF-H5247 Human Human M-CSF / CSF-1 Protein, His Tag

M-CSF Part of Bioactivity data


Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).


Human M-CSF, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R, Fc Tag, low endotoxin (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

M-CSF Molecule Synonym Name


M-CSF Molecule Background

The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 receptor. Macrophage colony-stimulating factor has been shown to interact with PIK3R2. M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. Locally produced M-CSF in the vessel wall contributes to the development and progression of atherosclerosis.

M-CSF References

M-CSF Related Molecule

M-CSF Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Lacnotuzumab MCS-110 Phase Ⅱ Novartis Bone metastases from solid tumors, Prostate cancer, Breast cancer, Solid tumours, Tenosynovial giant cell tumor (TGCT), Pigmented villonodular synovitis Details
Granulocyte-macrophage colony stimulating factor (Otsuka Pharmaceutical) Phase Ⅰ Otsuka Immunostimulant Details
Sargramostim therapy (Innoventus Project) Phase Ⅰ Innoventus Project Periodontitis Details
PD-360324 PD-360324; PD-0360324 Phase Ⅱ Pfizer Solid tumours Details

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