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Brief Information

Name:Macrophage Colony Stimulating Factor 1
Target Synonym:M-CSF,Macrophage colony-stimulating factor 1,CSF-1,CSF1,Colony Stimulating Factor 1,Colony Stimulating Factor 1 (Macrophage),Macrophage Colony Stimulating Factor 1,Lanimostim,MCSF,Macrophage Colony-Stimulating Factor,MGC31930
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

MCF-H5218-Cell-based assay

Human M-CSF Protein, premium grade (Cat. No. MCF-H5218) stimulates proliferation of M-NFS-60 cells. The specific activity of Human M-CSF, premium grade is>6.0*10^7 IU/mg, which is calibrated against WHO International Standard (NIBSC code: 89/512) (QC tested).

MCF-H82E6-Cell-based assay

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) stimulates proliferation of RAW264.7 cells. The EC50 for this effect is 6.20-7.15 ng/mL (Routinely tested).


Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).


Human M-CSF, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R, Fc Tag, low endotoxin (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name



The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 receptor. Macrophage colony-stimulating factor has been shown to interact with PIK3R2. M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. Locally produced M-CSF in the vessel wall contributes to the development and progression of atherosclerosis.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Lacnotuzumab MCS-110 Phase 2 Clinical Novartis Pharma Ag Bone metastases; Giant Cell Tumor of Tendon Sheath; Stomach Neoplasms; Synovitis, Pigmented Villonodular; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Breast Neoplasms; Giant Cell Tumors; Endometrial Neoplasms; Melanoma Details

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