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Your Position: Home > Integrin alpha 6 beta 1

Integrin alpha 6 beta 1

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Cat. No. Species Product Description Structure Purity Feature
IT1-H52W7 Human Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer Protein, His Tag&Tag Free
IT1-H52W7-structure
IT1-H52W7-sds
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Part of Bioactivity data

IT1-H52W7-SPR
Integrin alpha 6 beta 1 SPR

Human ITGA6&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W7) captured on CM5 chip via anti-His antibody can bind Human Laminin 511 E8, Fc Tag (Cat. No. LA8-H5283) with an affinity constant of 8.01 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
IT1-H52W7-BLI
Integrin alpha 6 beta 1 BLI

Loaded Human Laminin 511 E8, Fc Tag (Cat. No. LA8-H5283) on Protein A Biosensor, can bind Human ITGA6&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W7) with an affinity constant of 6.65 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

Integrin alpha 6 beta 1,ITGA6&ITGB1

Background

Integrin alpha 6 beta 1, also called platelet glycoprotein GPIc-IIa, is a receptor for laminin on platelets. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. ITGA6 has been shown to interact with TSPAN4 and GIPC1.

Clinical and Translational Updates

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