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TNFSF11

Brief Information

Name:Tumor necrosis factor ligand superfamily member 11
Target Synonym:Osteoclast differentiation factor,TRANCE,TNFSF11,TNF-related activation-induced cytokine,Tumor necrosis factor ligand superfamily member 11,CD254,TNF Superfamily Member 11,Osteoprotegerin Ligand,Receptor Activator Of Nuclear Factor Kappa B Ligand,Tumor Necrosis Factor Superfamily Member 11,ODF,RANKL,OPGL,CD254 Antigen,HRANKL2,TNLG6B,OPTB2,SOdf,RANK Ligand,Tumor Necrosis Factor (Ligand) Superfamily, Member 11,Receptor Activator Of Nuclear Factor Kappa-B Ligand,Tumor Necrosis Factor Ligand 6B
Number of Launched Drugs:6
Number of Drugs in Clinical Trials:27
Lastest Research Phase:Approved

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Part of Bioactivity data

RAL-H5265-SPR
 TNFSF11 SPR

Captured Human RANK, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. RAK-H5251) on CM5 chip via Anti-Mouse antibodies surface can bind Human TNFSF11, Fc Tag (Cat. No. RAL-H5265) with an affinity constant of 0.574 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

RAL-H5240-SPR
 TNFSF11 SPR

Anti-TNFSF11 (human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human TNFSF11 Protein, His Tag (Cat. No. RAL-H5240) with an affinity constant of 0.274 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

RANKL,CD254,TRANCE,OPGL,ODF

Background

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Denosumab biosimilar (Qilu Pharma) QL-1206 Approved Qilu Pharmaceutical Co Ltd 鲁可欣 Mainland China Osteoporosis, Postmenopausal Qilu Pharmaceutical Co Ltd 2023-09-28 Solid tumours; Bone metastases; Osteoporosis, Postmenopausal Details
Narlumosbart JMT-103 Approved Shanghai Jmt-Bio Inc 津立生 Mainland China Giant Cell Tumor of Bone Shanghai Jmt-Bio Inc 2023-09-05 Solid tumours; Bone metastases; Osteoporosis; Osteoporosis, Postmenopausal; Hypercalcemia; Neoplasms; Giant Cell Tumor of Bone; Glucocorticoid-induced osteoporosis Details
Denosumab biosimilar(Reliance Life Sciences) R-TPR-045 Approved Reliance Life Sciences DenosuRel India Osteoporosis, Postmenopausal; Bone metastases Reliance Life Sciences 2022-02-01 Bone metastases; Osteoporosis, Postmenopausal Details
Denosumab biosimilar (Mabwell) 9-MW-0311; 9MW0321; 9-MW0321; 9MW-0321; 9-MW-0321; TK-006; MW-032; MW-031; 9MW0311; 9-MW0311; 9MW-0311 Approved Jiangsu T-Mab Bio-Pharmaceuticals Co Ltd 迈利舒 Mainland China Osteoporosis, Postmenopausal Jiangsu T-Mab Bio-Pharmaceuticals Co Ltd 2023-03-28 Bone metastases; Solid tumours; Osteoporosis; Osteoporosis, Postmenopausal; Breast Neoplasms; Bone Neoplasms Details
Denosumab NSC-744010; AMG-162 Approved Amgen Inc Prolia, Xgeva, Pralia, Ranmark, 普罗力 EU Osteoporosis, Postmenopausal Amgen Europe Bv 2010-05-26 Lymphoma; Prostatic Neoplasms, Castration-Resistant; Feeding and Eating Disorders; Breast Neoplasms; Prostatic Neoplasms; Giant Cell Tumors; Osteosarcoma; Arthropathy, Neurogenic; Osteogenesis Imperfecta; Giant Cell Tumor of Bone; Bone Neoplasms; Breast Diseases; Fractures, Bone; Multiple Myeloma; Lung Neoplasms; Osteoblastoma; Granuloma, Giant Cell; Thyroid Neoplasms; Lymphoma, Non-Hodgkin; Glucocorticoid-induced osteoporosis; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Fibroma; Crohn Disease; Anorexia Nervosa; Fibrous Dysplasia of Bone; Kidney Neoplasms; Solid tumours; Cataract; Endocrine Gland Neoplasms; Head and Neck Neoplasms; Hematopoietic stem cell transplantation (HSCT); Hematologic Neoplasms; Bone Diseases, Metabolic; Osteoporosis; Carcinoma; Pain; Parathyroid Neoplasms; Bone metastases; Osteoporosis, Postmenopausal; Smoldering Multiple Myeloma; Colonic Neoplasms; Hypercalcemia; Neoplasms; Chondroblastoma; Kidney Diseases; Carcinoma, Ovarian Epithelial; Bone Disease Details
Denosumab biosimilar (Boan Biopharma/Luye) LY-01011; BA-1102; BA-6101; LY-06006 Approved Shandong Boan Biotechnology Co Ltd, Luye Pharma Group Ltd Mainland China Osteoporosis, Postmenopausal Shandong Boan Biotechnology Co Ltd 2022-11-10 Bone metastases; Solid tumours; Osteoporosis; Osteoporosis, Postmenopausal; Neoplasms; Multiple Myeloma; Giant Cell Tumor of Bone; Bone Neoplasms; Neoplasm Metastasis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant human anti-RANKL momoclonal antibody (Qilu Pharmaceutical) Phase 3 Clinical Qilu Pharmaceutical Co Ltd Osteoporosis, Postmenopausal; Neoplasms Details
Recombinant human anti-RANKL antibody (Innovent Biologics) IBI-307 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Osteoporosis Details
Denosumab biosimilar(Mabxience) Phase 3 Clinical Mabxience Sa Osteoporosis, Postmenopausal Details
Recombinant anti-RANKL monoclonal antibody(Jiangsu Pacific-Meinuoke) Phase 1 Clinical Jiangsu Pacific-Meinuoke Bio-Pharmaceutical Co Ltd Osteoporosis, Postmenopausal Details
Denosumab biosimilar(Alvotech Swiss) AVT-03 Phase 3 Clinical Alvotech Swiss Ag Osteoporosis, Postmenopausal Details
Denosumab biosimilar (Hualan Biological Engineering) Phase 3 Clinical Hualan Genetic Engineering Co Ltd Solid tumours; Bone metastases; Osteoporosis, Postmenopausal Details
Denosumab biosimilar (Henlius ) HLX-14; HLX14 Phase 3 Clinical Shanghai Henlius Biotech Inc Osteoporosis, Postmenopausal Details
Denosumab biosimilar (Intas Biopharmaceuticals) Phase 3 Clinical Intas Biopharmaceuticals Osteoporosis, Postmenopausal Details
Denosumab biosimilar(Fresenius Kabi) FKS-518 Phase 3 Clinical Fresenius Kabi Swissbiosim Gmbh Osteoporosis, Postmenopausal Details
Denosumab biosimiliar (Celltrion) CT-P41 Phase 3 Clinical Celltrion Inc Osteoporosis, Postmenopausal Details
MV-088 MV-088 Phase 1 Clinical Kpc Pharmaceuticals Inc Osteoporosis, Postmenopausal Details
GB-223 GB-223 Phase 1 Clinical Genor Biopharma Co Ltd Solid tumours; Bone metastases; Osteoporosis, Postmenopausal; Bone Neoplasms; Giant Cell Tumor of Bone Details
KP-46 KP-46; FFC-11; LX-001; AP-002 Phase 2 Clinical University Of Heidelberg, Meram Solid tumours Details
Denosumab biosimilar (AryoGen) Phase 3 Clinical Aryogen Biopharma Osteoporosis Details
LZM-004 LZM-004 Phase 1 Clinical Livzon(Group) Pharmaceutical Factory Bone metastases Details
TVB-009 TVB-009 Phase 3 Clinical Teva Pharmaceutical Industries Ltd Osteoporosis, Postmenopausal Details
Denosumab biosimilar(Shanghai Hansoh) HS-20090; HS-20090-2 Phase 3 Clinical Shanghai Hansoh Biomedical Co Ltd, Jiangsu Hansoh Pharmaceutical Group Co Ltd Bone metastases; Solid tumours; Neoplasms; Osteoporosis, Postmenopausal; Bone Diseases; Hypercalcemia; Multiple Myeloma; Giant Cell Tumor of Bone; Nutritional and Metabolic Diseases Details
Denosumab biosimilar (Samsung Bioepis) SB-16 Phase 3 Clinical Samsung Bioepis Co Ltd Osteoporosis, Postmenopausal Details
Denosumab biosimilar(Enzene Biosciences) ENZ-215 Phase 3 Clinical Enzene Biosciences Ltd Osteoporosis, Postmenopausal Details
Recombinant human anti-RANKL antibody (Hisun Pharma) HS629 Phase 1 Clinical Zhejiang Hisun Pharmaceutical Co Ltd Bone metastases; Solid tumours Details
RGB-14-P RGB-14-P Phase 3 Clinical Gedeon Richter Plc Osteoporosis, Postmenopausal Details
CMAB807 CMAB-807; CMAB807X Phase 3 Clinical Shanghai Biomabs Pharmaceuticals Co Ltd, Shanghai Maitai Yabo Biotechnology Co Ltd Osteoporosis, Postmenopausal Details

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