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Your Position: Home > IL-17A & IL-17F

IL-17A & IL-17F

Brief Information

Name:Interleukin 17A
Target Synonym:Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8),CTLA8,IL17A,Interleukin 17A,Cytotoxic T-Lymphocyte-Associated Antigen 8,Cytotoxic T-Lymphocyte-Associated Protein 8,CTLA-8,IL-17A,IL-17,IL17,Interleukin-17A
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:27
Lastest Research Phase:Approved

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Part of Bioactivity data

ILF-H52W6-Cell-based assay
 IL-17A & IL-17F CELL

Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (Cat. No. ILF-H52W6) stimulates production of IL-6 in NIH-3T3 cells in the presence of 200 ng/mL human TNF-alpha. The EC50 for this effect is 11.34-12.46 ng/mL (Routinely tested).

ILF-H52W6-SPR
 IL-17A & IL-17F SPR

Human IL17RA & IL17RC Protein, Fc Tag&Fc Tag (Cat. No. ILC-H5257) captured on CM5 chip via anti-human IgG Fc antibody can bind Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (Cat. No. ILF-H52W6) with an affinity constant of 50.8 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ILF-H52W6-BLI
 IL-17A & IL-17F BLI

Loaded Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) on Protein A Biosensor, can bind Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (Cat. No. ILF-H52W6) with an affinity constant of 3.70 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL-17A & IL-17F Molecule Synonym Name

IL-17A,Interleukin-17A,CTLA-8,IL-17,IL-17F,Interleukin-17F,Cytokine ML-1

IL-17A & IL-17F Molecule Background

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

IL-17A & IL-17F References

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Virulizin Approved Aptose Virulizin, Virulizin-2 gamma Mexico Sarcoma, Kaposi; Melanoma; Carcinoma, Renal Cell; Colorectal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Uterine Cervical Neoplasms null 1997-01-01 Carcinoma, Renal Cell; Stomach Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Sarcoma, Kaposi; Melanoma; Uterine Cervical Neoplasms Details
Secukinumab NVP-AIN-457; AIN-457; KB-03303A Approved Novartis Pharma Ag 可善挺, Scapho, Cosentyx Japan Arthritis, Psoriatic; Psoriasis Novartis Pharma Ag 2014-12-26 Hidradenitis Suppurativa; Polymyalgia Rheumatica; Ichthyosis, Lamellar; Psoriasis; Tendinopathy; Hyperkeratosis, Epidermolytic; Arthritis, Psoriatic; Tendon Injuries; Asthma; Lichen Planus; Arthritis, Juvenile; Uveitis; Arthritis; Inflammation; Plaque psoriasis; Behcet Syndrome; Crohn Disease; Gastroenteritis; Dermatitis, Atopic; Ichthyosiform Erythroderma, Congenital; Spondylitis, Ankylosing; Non-radiographic axial spondyloarthritis; Necrobiosis Lipoidica; Diabetes Mellitus, Type 1; Giant Cell Arteritis; Alopecia Areata; Pyoderma Gangrenosum; Lupus Erythematosus, Discoid; Non-alcoholic Fatty Liver Disease; Inflammatory Bowel Diseases; Multiple Sclerosis, Relapsing-Remitting; Rotator Cuff Injuries; Spondylarthritis; Arthritis, Rheumatoid; Spondylarthropathies; Netherton Syndrome; Ichthyosis; Lupus Nephritis; Graves Ophthalmopathy; Multiple Sclerosis Details
Ixekizumab LY-2439821 Approved Eli Lilly And Company 拓咨, Taltz United States Psoriasis Eli Lilly And Company 2016-03-22 Diabetes Mellitus, Type 1; Non-radiographic axial spondyloarthritis; Depressive Disorder, Major; Pyoderma Gangrenosum; Spondylarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Lichen Planus; Pemphigoid, Bullous; Pityriasis Rubra Pilaris; Plaque psoriasis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
UCB-0159 UCB-0159 Phase 1 Clinical Ucb Sa Autoimmune Diseases Details
Isomyosamine MYMD-1 Phase 2 Clinical Mymd Pharmaceuticals Inc Depression; Anxiety; Hashimoto Disease; Frailty; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Healthy Aging; Inflammation; Sarcopenia Details
CNTO-6785 CNTO-6785; FTC-001 Phase 1 Clinical Morphosys Ag, Janssen Global Services Llc Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Pulmonary Disease, Chronic Obstructive Details
QX002N QX-002N Phase 3 Clinical Qyuns Therapeutics Co Ltd Spondylitis, Ankylosing; Asthma Details
ZL-1102 ZL-1102; CB-001 Phase 1 Clinical Crescendo Biologics Ltd, Zai Lab (Shanghai) Co Ltd Psoriasis Details
Secukinumab biosimilar (Gan & Lee) GLR1023; GLR-1023 Phase 1 Clinical Gan & Lee Pharmaceuticals Plaque psoriasis Details
CJM-112 CJM-112 Phase 2 Clinical Novartis Pharma Ag Acne Vulgaris; Triple Negative Breast Neoplasms; Multiple Sclerosis; Multiple Myeloma; Psoriasis; Asthma; Colorectal Neoplasms; Hidradenitis Suppurativa; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Sonelokimab M-1095; ALX-0761; MSB-0010841 Phase 2 Clinical Ablynx Nv Psoriasis; Arthritis, Psoriatic; Hidradenitis Suppurativa Details
HY-1770 HY1770; HT-17; HT17; HY-1770 Phase 1 Clinical Suzhou Pharmavan Co Ltd Dermatitis, Atopic; Plaque psoriasis Details
SSGJ-608 608; SSGJ-608 Phase 3 Clinical Sunshine Guojian Pharmaceutical (Shanghai) Co Ltd Spondylitis, Ankylosing; Spondylarthritis; Plaque psoriasis Details
Secukinumab biosimilar (Bio-Thera Solutions) BAT-2306 Phase 3 Clinical Bio-Thera Solutions Ltd Autoimmune Diseases; Psoriasis; Plaque psoriasis Details
Roconkibart JS005 Phase 3 Clinical Shanghai Junshi Biosciences Co Ltd Non-radiographic axial spondyloarthritis; Spondylarthritis; Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
JNJ-61178104 JNJ-61178104 Phase 1 Clinical Janssen Global Services Llc Autoimmune Diseases Details
Secukinumab Biosimilar(Celltrion) CT-P55 Phase 1 Clinical Celltrion Inc Plaque psoriasis Details
JNJ-63823539 JNJ-63823539 Phase 1 Clinical Janssen Global Services Llc Arthritis, Rheumatoid Details
Izokibep IMG-020; IMG020; ABY-035; AFB-035 Phase 3 Clinical Affibody Ab Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis; Plaque psoriasis Details
LEO-153339 LEO-153339 Phase 1 Clinical Leo Pharma Inc Details
IMU-935 IMU-935 Phase 1 Clinical Immunic Ag Prostatic Neoplasms, Castration-Resistant Details
Gumokimab AK-111 Phase 3 Clinical Zhongshan Akeso Biopharma Co Ltd Non-radiographic axial spondyloarthritis; Spondylarthritis; Spondylitis, Ankylosing; Skin Diseases; Psoriasis; Plaque psoriasis Details
CMAB-015 CMAB015; CMAB-015 Phase 1 Clinical Taizhou Mabtech Pharmaceutical Co Ltd Spondylitis, Ankylosing; Plaque psoriasis Details
anti-IL-17A humanized monoclonal antibody(Fontacea ) Phase 1 Clinical Shandong Fangtansi Biopharmaceutical Co Ltd Plaque psoriasis Details
Secukinumab biosimilar (CSPC Pharmaceutical Group) SYS6012; SYS-6012 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Plaque psoriasis Details
DMT-310 DMT-310 Phase 3 Clinical Dermata Acne Vulgaris; Rosacea Details
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) LZM-012; LZM012; XKH004; XKH-004 Phase 3 Clinical Beijing Kanova Biomedical Technology Co Ltd, Livzon Pharmaceutical Group Inc Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
SIM-0335 SIM-0335; SIM-335 Phase 2 Clinical BCY Pharm Co Ltd Plaque psoriasis Details

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