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Your Position: Home > TSLP R

TSLP R

Brief Information

Name:Thymic stromal lymphopoietin
Target Synonym:Thymic stromal lymphopoietin,TSLP
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:16
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
TSR-H525a Human Human TSLP R Protein, Fc Tag
TSR-H525a-structure
TSR-H525a-sds
ACRO Quality

Part of Bioactivity data

TSR-H525a-SPR
 TSLP R SPR

Captured Human TSLP Protein, His Tag, premium grade (Cat. No. TSP-H52Hb) on CM5 Chip via anti-His antibody, can bind Human TSLP R, Fc Tag (Cat. No. TSR-H525a) with an affinity constant of 1.81 nM as determined in SPR assay (Biacore T200) (Routinely tested).

TSR-H525a-SPR
 TSLP R SPR

Captured Human TSLP (R127A, R130A), His Tag (Cat. No. TSP-H52Ha) on CM5 Chip via anti-His antibody, can bind Human TSLP R, Fc Tag (Cat. No. TSR-H525a) with an affinity constant of 4.22 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

TSLP R,CRLF2,IL-XR,ILXR, p2RY8/CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2

Background

Receptor for thymic stromal lymphopoietin (TSLP). CRLF2 / TSLPR is a member of the type I cytokine receptor family. Together with the interleukin 7 receptor (IL7R) and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tezepelumab AMG-157; MEDI-9929 Approved Amgen Inc Tezspire United States Asthma Astrazeneca Ab 2021-12-17 Eosinophilic Esophagitis; Hypersensitivity; Dermatitis, Atopic; Hypersensitivity, Immediate; Bronchial Diseases; Pulmonary Disease, Chronic Obstructive; Sinusitis; Respiratory Hypersensitivity; Asthma; Lung Diseases, Obstructive; Immune System Diseases; Lung Diseases; Respiratory Tract Diseases; Nasal Polyps; Nose Diseases; Chronic Urticaria; Carcinoma; Anaphylaxis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HBM-9378 SKB378; HBM-9378 Phase 1 Clinical Harbour Biomed, Sichuan Kelun-Biotech Biopharmaceutical Co Ltd Asthma Details
WIN-1001X WIN-1001X Phase 2 Clinical Whanin Pharmaceutical Co Ltd Nerve Degeneration; Parkinson Disease Details
GR2002 GR2002 Phase 1 Clinical Nasal Polyps; Asthma; Sinusitis; Dermatitis, Atopic Details
BSI-045B BSI-045B; TQC-2731; TQC2731 Phase 2 Clinical Biosion Inc Nasal Polyps; Sinusitis; Asthma; Dermatitis, Atopic Details
CM-326(Connaught Biomedical Technology) CM-326 Phase 2 Clinical Keymed Biosciences Co Ltd Nasal Polyps; Nose Diseases; Sinusitis; Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
AZD-8630 AZD-8630; AMG-104 Phase 1 Clinical Astrazeneca Plc, Amgen Inc Asthma Details
STSA-1201 STSA-1201; STSA1201 Phase 1 Clinical Staidson(Beijing) Biopharmaceuticals Co Ltd Asthma Details
PF-06342674 RN-168; PF-6342674; PF-06342674; ZB-168 Phase 1 Clinical Pfizer Inc Diabetes Mellitus, Type 1; Multiple Sclerosis Details
SHR-1905 SHR-1905; AIO-001 Phase 2 Clinical Shanghai Hengrui Pharmaceutical Co Ltd Nasal Polyps; Nose Diseases; Respiratory Tract Diseases; Sinusitis; Asthma Details
Ecleralimab CSJ-117; NOV-14 Phase 2 Clinical Novartis Pharma Ag Asthma; Pulmonary Disease, Chronic Obstructive Details
LQ043H LQ043H Phase 1 Clinical Shanghai Novamab Biopharmaceuticals Co Ltd Asthma Details
PF-07275315 PF-07275315 Phase 2 Clinical Pfizer Inc Dermatitis, Atopic Details
GR-1802 GR-1802 Phase 3 Clinical Nose Diseases; Chronic Urticaria; Nasal Polyps; Asthma; Sinusitis; Dermatitis, Atopic Details
Lunsekimig SAR-443765 Phase 2 Clinical Sanofi Asthma; Inflammation Details
QX-008N QX008N; QX-008N Phase 1 Clinical Qyuns Therapeutics Co Ltd Asthma; Pulmonary Disease, Chronic Obstructive Details
BD-9 BD-9 Biolojic Design Inc Details

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