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Your Position: Home > CA125

CA125

Brief Information

Name:Mucin-16
Target Synonym:Mucin-16 Short Isoform,Mucin-16 Long Isoform,Ovarian carcinoma antigen CA125,Ovarian cancer-related tumor marker CA125,MUC16,MUC-16,CA-125,Mucin 16, Cell Surface Associated,CA125,CA125 Ovarian Cancer Antigen,Mucin-16,CA-125 Antigen,FLJ14303
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CA5-R52H3 Rhesus macaque Rhesus macaque CA125 / MUC16 (12664-12920) Protein, His Tag (MALS verified)
CA5-R52H3-structure
CA5-R52H3-sds
CA5-R52H3-elisa_1
CA5-R52H6 Rhesus macaque Rhesus macaque CA125 / MUC16 (13647-14291) Protein, His Tag (MALS verified)
CA5-R52H6-structure
CA5-R52H6-sds
CA5-R52H6-elisa_1
CA5-H52H6 Human Human CA125 / MUC16 (13810-14451) Protein, His Tag (MALS verified)
CA5-H52H6-structure
CA5-H52H6-sds
CA5-H52H6-elisa_1
CA5-H82F8 Human Biotinylated Human CA125 / MUC16 (13810-14451) Protein, Fc,Avitag™
CA5-H82F8-structure
CA5-H82F8-sds
CA5-H82F4 Human Biotinylated Human CA125 / MUC16 Protein, Fc,Avitag™
CA5-H82F4-structure
CA5-H82F4-sds
CA5-H82F4-elisa_1

Part of Bioactivity data

CA5-R52H6-ELISA
Rhesus macaque CA125 (13647-14291), His TagRhesus macaque CA125 (13647-14291), His Tag (Cat. No. CA5-R52H6) ELISA bioactivity

Immobilized Rhesus macaque CA125 (13647-14291), His Tag (Cat. No. CA5-R52H6) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Mesothelin, Fc,Avitag (Cat. No. MSN-H82F6) with a linear range of 0.002-0.313 μg/mL (QC tested).

Protocol
CA5-R52H3-MALS-HPLC
Rhesus macaque CA125 (12664-12920), His Tag (Cat. No. ) MALS images

The purity of Rhesus macaque CA125 (12664-12920), His Tag (Cat. No. CA5-R52H3) is more than 90% and the molecular weight of this protein is around 55-70 kDa verified by SEC-MALS.

Report
Bioactivity-ELISA
Rhesus macaque CA125 (12664-12920), His TagRhesus macaque CA125 (12664-12920), His Tag (Cat. No. CA5-R52H3) ELISA bioactivity

Immobilized Rhesus macaque CA125 (12664-12920), His Tag (Cat. No. CA5-R52H3) at 5 μg/mL (100 μL/well) can bind Human Mesothelin (296-580), Fc Tag (Cat. No. MSN-H5253) with a linear range of 1-20 ng/mL (QC tested).

Synonym Name

CA125,CA-125,CA125MUC-16,FLJ14303,MUC16,mucin 16,mucin-16

Background

The CA125, also known as the MUC16, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. The CA 125 molecule is almost certainly a glycoprotein with a predominance of O-linkages. It is heterogeneous with regard to both size and charge, most likely due to continuous deglycosylation of side chains during its life-span in bodily fluids. It exists as a very large complex (perhaps as much as 4 million daltons) under natural conditions.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
JCAR-020 JCAR-020 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Ovarian Neoplasms Details
Ubamatamab REGN-4018 Phase 2 Clinical Regeneron Pharmaceuticals Inc Ovarian Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
REGN-5668 REGN-5668 Phase 2 Clinical Regeneron Pharmaceuticals Ovarian Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details
Oregovomab B43.13 Phase 3 Clinical Paladin Pharma Ovarian Neoplasms; Carcinoma; Abdominal Neoplasms; Carcinoma, Ovarian Epithelial; Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Adenocarcinoma Details
PRGN-3005 PRGN-3005 Phase 1 Clinical Precigen Ovarian Neoplasms; Esophageal Neoplasms; Sarcoma; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Lymphoma, Non-Hodgkin; Uterine Cervical Neoplasms Details

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