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CA125 Molecule Information

Target Synonym:Mucin-16;CA125;Ovarian carcinoma antigen CA125;CA-125;MUC16;MUC-16;Ovarian cancer-related tumor marker CA125
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Withdrawn

CA125 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
CA5-H82F8 Human Biotinylated Human CA125 / MUC16 (13810-14451) Protein, Fc,Avitag™
CA5-H82F4 Human Biotinylated Human CA125 / MUC16 Protein, Fc,Avitag™

CA125 Part of Bioactivity data

Biotinylated Human CA125, Fc,AvitagBiotinylated Human CA125, Fc,Avitag (Cat. No. CA5-H82F4) ELISA bioactivity

Immobilized Human Mesothelin, His Tag (Cat. No. MSN-H5223) at 10 μg/mL (100 μL/well) can bind Biotinylated Human CA125, Fc,Avitag (Cat. No. CA5-H82F4) with a linear range of 2-78 ng/mL (QC tested).

CA125 Molecule Synonym Name

CA125, CA-125, CA125MUC-16, FLJ14303, MUC16, mucin 16, mucin-16

CA125 Molecule Background

The CA125, also known as the MUC16, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. The CA 125 molecule is almost certainly a glycoprotein with a predominance of O-linkages. It is heterogeneous with regard to both size and charge, most likely due to continuous deglycosylation of side chains during its life-span in bodily fluids. It exists as a very large complex (perhaps as much as 4 million daltons) under natural conditions.

CA125 References

CA125 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
RG-7882 RG-7882; D-4064A; DMUC-4064A Phase Ⅰ Genentech Ovarian cancer, Pancreatic cancer Details
Igovomab Withdrawn CIS bio international Ovarian cancer Details
Oregovomab MAb-B43.13; B43.13 Phase Ⅲ Paladin Pharma, National Cancer Institute, Quest PharmaTech, University of Nebraska Medical Center Ovarian cancer, Pancreatic cancer Details
Sofituzumab vedotin RG-7458; DMUC-5754A Phase Ⅰ Genentech Fallopian tube cancer, Peritoneum cancer, Ovarian cancer, Pancreatic cancer Details
JCAR-020 JCAR-020 Phase Ⅰ Memorial Sloan-Kettering Cancer Center, Juno Therapeutics Ovarian cancer Details

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