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Siglec-10

Brief Information

Name:Sialic acid-binding Ig-like lectin 10
Target Synonym:UNQ477/PRO940,SIGLEC10,Sialic Acid Binding Ig Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7,Siglec-Like Protein 2,Siglec-Like Gene 2,SLG2,Sialic Acid-Binding Ig-Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10,Siglec-10,PRO940,MGC126774
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

SI0-HP2E5-Cell-based assay
 Siglec-10 FACS

2e5 of 293 cells overexpressing human CD24 were stained with 100μL of 1:10 dilution of PE-Labeled Human Siglec-10 Protein, His Tag(recommended for neutralizing assay)(Cat. No. SI0-HP2E5)and negative control protein respectively , washed and analyzed with FACS (QC tested).

SI0-H5255-BLI
 Siglec-10 BLI

Loaded Human CD32a (R167), His Tag (Cat. No. CDA-H5221) on HIS1K Biosensor, can bind Human Siglec-10, Fc (L118A, G120A, E201A) Tag (Cat. No. SI0-H5255) with an affinity constant of 37.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

SI0-H5255-BLI
 Siglec-10 BLI

Loaded Human CD64, His Tag (Cat. No. FCA-H52H1) on HIS1K Biosensor, can bind Human Siglec-10, Fc (L118A, G120A, E201A) Tag (Cat. No. SI0-H5255) with an affinity constant of 42.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Customer Reviews

Synonym Name

SIGLEC10,MGC126774,PRO940,Siglec10,SLG2

Background

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AI-071 AI-071 Phase 1 Clinical Oncoimmune-Guangzhou Neoplasms; Coronavirus Disease 2019 (COVID-19) Details
EXO-CD24 Phase 2 Clinical Tel-Aviv Sourasky Medical Center, Nano24med Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc Solid tumours; Hematopoietic stem cell transplantation (HSCT); Leukemia; HIV Infections; Graft vs Host Disease; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details

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