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Siglec-10

Siglec-10 Molecule Information

Name:Sialic acid-binding Ig-like lectin 10
Target Synonym:Siglec-like protein 2;SLG2;Siglec-10;SIGLEC10
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase ?

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Siglec-10 Molecule Synonym Name

SIGLEC10,MGC126774,PRO940,Siglec10,SLG2

Siglec-10 Molecule Background

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 References

Siglec-10 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CD24-Fc CD24-Fc; CD24-Fc-IgG; HAS-CD24 Phase Ⅱ OncoImmune, National Institute of Neurological Disorders and Stroke, University of Michigan, The Ohio State University Comprehensive Cancer Center Graft versus host disease Details

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