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Siglec-10

Brief Information

Name:Sialic acid-binding Ig-like lectin 10
Target Synonym:UNQ477/PRO940,SIGLEC10,Sialic Acid Binding Ig Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7,Siglec-Like Protein 2,Siglec-Like Gene 2,SLG2,Sialic Acid-Binding Ig-Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10,Siglec-10,PRO940,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

SI0-H82E3-ELISA
Biotinylated Human Siglec-10, His,AvitagBiotinylated Human Siglec-10, His,Avitag (Cat. No. SI0-H82E3) ELISA bioactivity

Immobilized Biotinylated Human Siglec-10, His,Avitag (Cat. No. SI0-H82E3) at 5 μg/mL (100 μL/well) on Streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate, can bind Anti-Human Siglec-10 MAb, human IgG with a linear range of 0.6-20 ng/mL (QC tested).

SI0-C52H5-ELISA
Cynomolgus Siglec-10, His TagCynomolgus Siglec-10, His Tag (Cat. No. SI0-C52H5) ELISA bioactivity

Immobilized Cynomolgus Siglec-10, His Tag (Cat. No. SI0-C52H5) at 1 μg/mL (100 μL/well) on an Nickel Coated plate can bind Anti-Siglec-10 Antibody, Human IgG1 with a linear range of 0.04-0.313 μg/mL (QC tested).

Synonym Name

SIGLEC10,MGC126774,PRO940,Siglec10,SLG2

Background

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CD24-Fc MK-7110; MK7110; HAS-CD24; CD24-Fc-IgG; CD24-Fc Phase 3 Clinical Oncoimmune HIV Infections; Hematopoietic stem cell transplantation (HSCT); Leukemia; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Dyslipidemias; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Melanoma Details
EXO-CD24 Phase 2 Clinical Tel-Aviv Sourasky Medical Center Coronavirus Disease 2019 (COVID-19) Details

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