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CTGF

Brief Information

Name:Connective tissue growth factor
Target Synonym:Cellular communication network factor 2,IBP-8,Hypertrophic chondrocyte-specific protein 24,IGF-binding protein 8,IGFBP-8,Connective tissue growth factor,IGFBP8,CCN2,Insulin-like growth factor-binding protein 8,HCS24,CCN family member 2,CTGF,NOV2
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

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Part of Bioactivity data

CTF-M52Hc-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Monoclonal Anti-Human CTGF Antibody, Human IgG1 on AHC Biosensor, can bind Mouse CTGF, His Tag (Cat. No. CTF-M52Hc) with an affinity constant of 2.46 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

CTF-H52H5-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Monoclonal Anti-Human CTGF Antibody, Human IgG1 on AHC Biosensor, can bind Human CTGF, His Tag (Cat. No. CTF-H52H5) with an affinity constant of 6.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8

Background

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Netarsudil Dimesylate AR-13224; AR-13324 Approved Aerie Pharmaceuticals Rhopressa EU Ocular Hypertension; Glaucoma, Open-Angle Aerie Pharmaceuticals Ireland Ltd 2017-12-18 Glaucoma, Open-Angle; Ocular Hypertension; Glaucoma; Corneal Edema; Fuchs' Endothelial Dystrophy Details
Penicillamine Approved Valeant Distamine, Pemine, Trisorcin, Cuprimine, Cupramine, Trolovol Mainland China Heavy Metal Poisoning; Arthritis, Rheumatoid; Hepatolenticular Degeneration; Lead Poisoning Sichuan Pharmaceutical Co Ltd 1970-12-04 Heavy Metal Poisoning; Arthritis, Rheumatoid; Hepatolenticular Degeneration; Cystinuria; Lead Poisoning Details
Netarsudil mesylate/Latanoprost PG-324 Approved Aerie Pharmaceuticals Inc Rocklatan, Roclanda EU Glaucoma, Open-Angle; Ocular Hypertension Aerie Pharmaceuticals Ireland Ltd 2019-03-12 Glaucoma, Open-Angle; Ocular Hypertension Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Setogepram PBI-4050 Phase 3 Clinical Prometic Life Sciences Cystic Fibrosis; Diabetes Mellitus, Type 2; Idiopathic Pulmonary Fibrosis; Metabolic Syndrome; Alstrom Syndrome; Diabetes Mellitus Details
RXI-109 RXI-109 Phase 2 Clinical Rxi Pharmaceutical Strongyloidiasis; Cicatrix; Keloid; Macular Degeneration; Cicatrix, Hypertrophic Details
OLX-10010 BMT-101; OLX-101; OLX-10010; cp-asiCTGF; OLX-101A Phase 2 Clinical Olix Pharmaceuticals Pulmonary Fibrosis; Wet Macular Degeneration; Cicatrix, Hypertrophic; Macular Degeneration Details
Pamrevlumab FG-3019 Phase 3 Clinical Fibrogen Diabetes Mellitus, Type 2; Idiopathic Pulmonary Fibrosis; Pancreatic Neoplasms; Liver Cirrhosis; Coronavirus Disease 2019 (COVID-19); Glomerulosclerosis, Focal Segmental; Muscular Dystrophy, Duchenne; Diabetic Nephropathies; Diabetes Mellitus Details

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