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CTGF Molecule Information

Name:Connective Tissue Growth Factor
Target Synonym:HCS24;IGFBP8;IGF-binding protein 8;CCN2 ;Insulin-like growth factor-binding protein 8;Hypertrophic chondrocyte-specific protein 24;IGFBP-8;Connective tissue growth factor;IBP-8;CTGF;CCN family member 2
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CTF-M52Hc Mouse Mouse CTGF / CCN2 Protein, His Tag
CTF-H52H5 Human Human CTGF / CCN2 Protein, His Tag
CTF-H82E6 Human Biotinylated Human CTGF / CCN2 Protein, His,Avitag™ (recommended for biopanning)

CTGF Molecule Synonym Name

CCN2, NOV2, HCS24, IGFBP8, IBP-8, IGFBP-8, IGF-binding protein 8

CTGF Molecule Background

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

CTGF References

CTGF Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Netarsudil Dimesylate AR-13324; AR-13224,AR13324 Approved Aerie Pharmaceuticals RHOPRESSA fda Ocular hypertension, Open-angle glaucoma AERIE PHARMS INC 2017-12-18 Ocular hypertension, Open-angle glaucoma Details
Netarsudil mesylate/Latanoprost PG-324 Approved Aerie Pharmaceuticals ROCKLATAN fda AERIE PHARMS INC 2019-03-12 Ocular hypertension, Glaucoma Details

CTGF Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Setogepram PBI-4050 Phase Ⅲ Prometic Life Sciences Alstrom Syndrome Details
OLX-10010 OLX-10010; BMT-101; OLX-101; cp-asiCTGF Phase Ⅱ OliX Pharmaceuticals, Hugel Skin hypertrophic scars Details
ALT-0701 ALT-0701 Phase Ⅱ AltruGen Fibrosis Details
RXI-109 RXI-109 Phase Ⅱ RXi Pharmaceutical Dermal scarring Details
OLX-701 OLX-701 Preclinical OliX Pharmaceuticals Hepatic fibrosis Details
EXC-001 EXC-001; PF-06473871; PF-6473871 Phase Ⅱ Ionis, Pfizer Skin hypertrophic scars Details
Pamrevlumab FG-3019 Phase Ⅲ FibroGen Idiopathic pulmonary fibrosis (IPF), Pancreatic cancer Details
OLX-201 OLX-201,OLX 201,OLX201 Preclinical Korea Institute of Toxicology, OliX Pharmaceuticals Idiopathic pulmonary fibrosis (IPF) Details
OLX-301 OLX-301,OLX301; OLX 301 Preclinical OliX Pharmaceuticals Fibrosis, Age-related macular degeneration (AMD) Details

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