Name:Connective Tissue Growth Factor Target Synonym:HCS24;IGFBP8;IGF-binding protein 8;CCN2 ;Insulin-like growth factor-binding protein 8;Hypertrophic chondrocyte-specific protein 24;IGFBP-8;Connective tissue growth factor;IBP-8;CTGF;CCN family member 2
Number of Launched Drugs:2 Number of Drugs in Clinical Trials:9 Lastest Research Phase:Approved
Loaded Monoclonal Anti-Human CTGF Antibody, Human IgG1 on AHC Biosensor, can bind Mouse CTGF, His Tag (Cat. No. CTF-M52Hc) with an affinity constant of 2.46 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Loaded Monoclonal Anti-Human CTGF Antibody, Human IgG1 on AHC Biosensor, can bind Human CTGF, His Tag (Cat. No. CTF-H52H5) with an affinity constant of 6.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8
CTGF Molecule Background
Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.