TPBG

TPBG

TPBG Overview

Molecule Name
Trophoblast glycoprotein
Synonyms
TPBG,5T4,M6P1,5T4AG,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein
Drug Development Progress
Drugs in Clinical Trials16
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
Trophoblast glycoprotein,5T4 oncotrophoblast glycoprotein,5T4,TPBG,5T4 oncofetal antigen,M6P1,5T4 oncofetal trophoblast glycoprotein,Wnt-Activated Inhibitory Factor 1,WAIF1,5T4AG,5T4-AG
Background
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.

TPBG Product List

Species
  • Human(6)
  • Cynomolgus / Rhesus macaque(2)
  • Mouse(2)
  • Rat(1)
Tag
  • His Tag(4)
  • His Tag & Avi Tag(4)
  • Fc Tag(2)
  • Fc Tag & Avi Tag(1)
Host
  • HEK293(11)
Conjugate
  • Unconjugated(8)
  • Biotin-labeled(3)
Grade
  • RUO(11)
Low Endotoxin
  • Yes(2)
  • No(9)
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&PriceAdd to Cart
TPBG
Unconjugated Human TPBG / 5T4 Protein, His,Avitag™
Human
HEK293
MALSSDS-PAGE
SPR

$1080.00

250ug
TPBG
Mouse TPBG / 5T4 Protein, His Tag (MALS verified)
Mouse
HEK293
MALSSDS-PAGE

$360.00

100ug
TPBG
Cynomolgus / Rhesus macaque TPBG / 5T4 Protein, His Tag
Cynomolgus / Rhesus macaque
HEK293
SDS-PAGE
ELISA

$360.00

100ug
TPBG
HOTAvitag
TPG-H82Eb
Biotinylated Human TPBG / 5T4 Protein, His,Avitag™
Human
HEK293
SDS-PAGE
ELISA

$380.00

25ug
TPBG
HOTAvitag
TPG-H52E5
Unconjugated Human TPBG / 5T4 Protein, His,AviTag, low endotoxin™ (Mass Spec & MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$280.00

50ug
TPBG
Avitag
TPG-C82E3
Biotinylated Cynomolgus / Rhesus macaque TPBG / 5T4 Protein, His,Avitag™
Cynomolgus / Rhesus macaque
HEK293
SDS-PAGE
ELISA

$368.00

25ug
TPBG
Human TPBG / 5T4 Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

100ug
TPBG
Human TPBG / 5T4 Protein, His Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$280.00

50ug
TPBG
Avitag
TPG-H82F6
Biotinylated Human TPBG / 5T4 protein, Fc,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$380.00

25ug
TPBG
Mouse TPBG / 5T4 Protein, Fc Tag (MALS verified)
Mouse
HEK293
MALSSDS-PAGE

$360.00

100ug
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Asset Licensing Opportunity

Antibody Project Trading Platform

Project NameProject StageMolecule TypeMolecule SourceDisease AreaIndication
5T4 mAb - 01LeadMonoclonalHumanized MouseSolid TumorOvarian cancer,Lung cancer
Project Name
5T4 mAb - 01
Project Stage
Lead
Molecule Type
Monoclonal
Molecule Source
Humanized Mouse
Disease Area
Solid Tumor
Indication
Ovarian cancer,Lung cancer
Resources

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Naptumomab estafenatoxTTS-CD3; ABR-217620Phase 2 ClinicalActive Biotech Ab
Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Melanoma; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms
Details
ALG.APV-527ALG.APV 527; ADC-1016; ATOR-1016; ALG.APV-527; ALG-APV-527Phase 2 ClinicalAlligator Bioscience Ab, Aptevo Therapeutics Inc
Neoplasms; Solid tumours
Details
JK-06JK-06Phase 2 ClinicalXinlitai (Chengdu) Biological Technology Co Ltd
Neoplasms; Solid tumours
Details
TUB-030TUB-030Phase 2 ClinicalTubulis GmbH
Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms
Details
ACR-246ACR246; ACR-246; ADC2154; ADC-2154Phase 2 ClinicalHangzhou Adcoris Biopharmacy Co Ltd
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Esophageal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Uterine Cervical Neoplasms
Details
IBR-854IBR854; IBR-854Phase 2 ClinicalImbioray (Hangzhou) Biomedicine Co Ltd
Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Solid tumours
Details
SYD-1875SYD-1875Phase 1 ClinicalSynthon Bv
Solid tumours
Details
ASN-004ASN-004Phase 1 ClinicalAsana Biosciences Llc
Solid tumours
Details
anti-5T4 CAR NK-cell therapy (Wuxi Peapole's Hospital/Hangzhou Yingbairui Biomedical Technology)Phase 1 ClinicalImbioray (Hangzhou) Biomedicine Co Ltd
Solid tumours
Details
Naptumomab estafenatox/DurvalumabNTX-352Phase 1 ClinicalNeotx Therapeutics Ltd
Solid tumours
Details
XB-010XB-010Phase 1 ClinicalExelixis Inc
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Esophageal Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms
Details
FTL-008.16FTL-008.16; FTL008.16Phase 1 ClinicalSound(Chengdu)Biopharmacauticals Co Ltd
Solid tumours
Details
CBA-1535CBA-1535Phase 1 ClinicalChiome Bioscience Inc
Carcinoma, Non-Small-Cell Lung; Mesothelioma; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms
Details
Anti-5T4 CAR-raNK Cell TherapyPhase 1 ClinicalImbioray (Hangzhou) Biomedicine Co Ltd
Solid tumours
Details
Prostate cancer vaccine(inactivated viral)(University of Oxford)ClinicalUniversity Of Oxford
Prostatic Neoplasms
Details
68Ga-NOTA-H006ClinicalHuashan Hospital
Solid tumours
Details
Customer Reviews