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TPBG
TPBG Overview
| English Name | Trophoblast glycoprotein | Approved Drugs | 0 |
| Drugs in Clinical Trials | 16 | Target Synonym | Trophoblast glycoprotein，5T4 oncotrophoblast glycoprotein，5T4，TPBG，5T4 oncofetal antigen，M6P1，5T4 oncofetal trophoblast glycoprotein，Wnt-Activated Inhibitory Factor 1，WAIF1，5T4AG，5T4-AG |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | Trophoblast glycoprotein |
| Target Synonym | Trophoblast glycoprotein，5T4 oncotrophoblast glycoprotein，5T4，TPBG，5T4 oncofetal antigen，M6P1，5T4 oncofetal trophoblast glycoprotein，Wnt-Activated Inhibitory Factor 1，WAIF1，5T4AG，5T4-AG |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 16 |
| Highest Development Stage | Phase 2 Clinical |
TPBG Product List
- Product Category
Protein (9)Cell (1)Antibody (1)
- Product Status
Launched (10)In Research (1)
- Species
Human (6)Cynomolgus / Rhesus macaque (1)Mouse (2)Rat (1)Rabbit (1)
- Tag
His Tag & Avi Tag (2)Fc Tag (2)His Tag (4)Fc Tag & Avi Tag (1)- (2)
- Conjugate
Biotin-labeled (2)Unconjugated (8)- (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
HOT TPG-H52E5 |  Human | HEK293 | Unconjugated Human TPBG / 5T4 Protein, His,Avitag™ (MALS verified) |  |  |  |  Add to Cart |
HOT TPG-H82Eb | Human | HEK293 | Biotinylated Human TPBG / 5T4 Protein, His,Avitag™ |  | | | Add to Cart |
HOT TPG-M52H3 |  Mouse | HEK293 | Mouse TPBG / 5T4 Protein, His Tag (MALS verified) |  | | Add to Cart | |
HOT TPG-C52H3 |  Cynomolgus / Rhesus macaque | HEK293 | Cynomolgus / Rhesus macaque TPBG / 5T4 Protein, His Tag |  | | | Add to Cart |
CHEK-ATP176 | Human | HEK293 | HEK293/Human TPBG Stable Cell Line |  | Add to Cart | ||
TPG-H5253 | Human | HEK293 | Human TPBG / 5T4 Protein, Fc Tag (MALS verified) |  | | | Add to Cart |
TPG-H52H3 | Human | HEK293 | Human TPBG / 5T4 Protein, His Tag (MALS verified) |  | | | Add to Cart |
TPG-H82F6 | Human | HEK293 | Biotinylated Human TPBG / 5T4 protein, Fc,Avitag™ (MALS verified) |  | | | Add to Cart |
TPG-M5255 | Mouse | HEK293 | Mouse TPBG / 5T4 Protein, Fc Tag (MALS verified) |  | | Add to Cart | |
HGS-M2717 |  Rabbit | - | Recombinant Monoclonal Anti-TPBG Antibody, Rabbit (P1B10) | Pre-order |
Total: 11
- 1
- 2
TPBG Background
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.
TPBG Synonyms
TPBG,5T4,M6P1,5T4AG,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein
Antibody Project Trading Platform
| Project Name | Project Stage | Molecule Type | Molecule Source | Disease Area | Indication |
|---|---|---|---|---|---|
| 5T4 mAb - 01 | Lead | Monoclonal | Humanized Mouse | Solid Tumor | Ovarian cancer,Lung cancer |
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Naptumomab estafenatox | TTS-CD3; ABR-217620 | Phase 2 Clinical | Active Biotech Ab | Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Melanoma; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | Details |
| ALG.APV-527 | ALG.APV 527; ADC-1016; ATOR-1016; ALG.APV-527; ALG-APV-527 | Phase 2 Clinical | Alligator Bioscience Ab, Aptevo Therapeutics Inc | Neoplasms; Solid tumours | Details |
| JK-06 | JK-06 | Phase 2 Clinical | Xinlitai (Chengdu) Biological Technology Co Ltd | Neoplasms; Solid tumours | Details |
| TUB-030 | TUB-030 | Phase 2 Clinical | Tubulis GmbH | Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms | Details |
| ACR-246 | ACR246; ACR-246; ADC2154; ADC-2154 | Phase 2 Clinical | Hangzhou Adcoris Biopharmacy Co Ltd | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Esophageal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Uterine Cervical Neoplasms | Details |
| IBR-854 | IBR854; IBR-854 | Phase 2 Clinical | Imbioray (Hangzhou) Biomedicine Co Ltd | Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Solid tumours | Details |
| SYD-1875 | SYD-1875 | Phase 1 Clinical | Synthon Bv | Solid tumours | Details |
| ASN-004 | ASN-004 | Phase 1 Clinical | Asana Biosciences Llc | Solid tumours | Details |
| anti-5T4 CAR NK-cell therapy (Wuxi Peapole's Hospital/Hangzhou Yingbairui Biomedical Technology) | Phase 1 Clinical | Imbioray (Hangzhou) Biomedicine Co Ltd | Solid tumours | Details | |
| Naptumomab estafenatox/Durvalumab | NTX-352 | Phase 1 Clinical | Neotx Therapeutics Ltd | Solid tumours | Details |
| XB-010 | XB-010 | Phase 1 Clinical | Exelixis Inc | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Esophageal Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms | Details |
| FTL-008.16 | FTL-008.16; FTL008.16 | Phase 1 Clinical | Sound(Chengdu)Biopharmacauticals Co Ltd | Solid tumours | Details |
| CBA-1535 | CBA-1535 | Phase 1 Clinical | Chiome Bioscience Inc | Carcinoma, Non-Small-Cell Lung; Mesothelioma; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms | Details |
| Anti-5T4 CAR-raNK Cell Therapy | Phase 1 Clinical | Imbioray (Hangzhou) Biomedicine Co Ltd | Solid tumours | Details | |
| Prostate cancer vaccine(inactivated viral)(University of Oxford) | Clinical | University Of Oxford | Prostatic Neoplasms | Details | |
| 68Ga-NOTA-H006 | Clinical | Huashan Hospital | Solid tumours | Details |
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