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Your Position: Home > GFR alpha-like

GFR alpha-like

Brief Information

Name:GDNF family receptor alpha-like
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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ACRO Quality

Part of Bioactivity data

 GFR alpha-like ELISA

Immobilized Rat GFR alpha-like, His Tag (Cat. No. GFA-R52H5) at 5 μg/mL (100 μL/well) can bind Human GDF-15, Fc Tag (Cat. No. GD5-H5269) with a linear range of 0.1-8 ng/mL (QC tested).

GFR alpha-like MALS images

The purity of Human GFR alpha-like, His Tag (Cat. No. GFA-H52H3) is more than 90% and the molecular weight of this protein is around 44-66 kDa verified by SEC-MALS.

Synonym Name

GFR alpha like,GFR alpha-like,GFRAL,GRAL


GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

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