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GFR alpha-like

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Part of Bioactivity data

GFE-H5259-ELISA
Human GFR alpha-like, Fc TagHuman GFR alpha-like, Fc Tag (Cat. No. GFE-H5259) ELISA bioactivity

Immobilized Human GDF-15, His Tag (Cat. No. GD5-H5149) at 1 μg/mL (100 μL/well) can bind Human GFR alpha-like, Fc Tag (Cat. No. GFE-H5259) with a linear range of 0.4-25 ng/mL (QC tested).

GFA-R52H7-ELISA
Rhesus macaque GFR alpha-like, His TagRhesus macaque GFR alpha-like, His Tag (Cat. No. GFA-R52H7) ELISA bioactivity

Immobilized Rhesus macaque GFR alpha-like, His Tag (Cat. No. GFA-R52H7) at 5 μg/mL (100 μL/well) can bind Human GDF-15, Fc Tag (Cat. No. GD5-H5269) with a linear range of 0.1-4 ng/mL (QC tested).

Synonym Name

GFR alpha like,GFR alpha-like,GFRAL,GRAL

Background

GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

Clinical and Translational Updates

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