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Your Position: Home > PSCA

PSCA

Brief Information

Name:Prostate stem cell antigen
Target Synonym:Prostate stem cell antigen,UNQ206/PRO232,PSCA,PRO232
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

PSA-H82E3-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-PSCA CAR-293 cells were stained with 100 μL of 3 μg/mL of Biotinylated Human PSCA, His,Avitag (Cat. No. PSA-H82E3) and negative control protein respectively, washed and then followed by PE-SA antibody and analyzed with FACS (Routinely tested).

PSA-H52H6-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-PSCA CAR-293 cells were stained with 100 μL of 3 μg/mL of Human PSCA, His Tag (Cat. No. PSA-H52H6) and negative control protein respectively, washed and then followed by PE anti-His Tag antibody and analyzed with FACS (Routinely tested).

PSA-M82E3-MALS-HPLC
Biotinylated Mouse PSCA, His,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Mouse PSCA, His,Avitag (Cat. No. PSA-M82E3) is more than 85% and the molecular weight of this protein is around 20-30 kDa verified by SEC-MALS.

  • Background
    The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored protein, plays an important role in tumorigenesis. The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. PSCA may be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    PSA-H82E3-MALS-HPLC
    Biotinylated Human PSCA, His,Avitag (Cat. No. ) MALS images

    The purity of Biotinylated Human PSCA, His,Avitag (Cat. No. PSA-H82E3) is more than 90% and the molecular weight of this protein is around 18-25 kDa verified by SEC-MALS.

Bioactivity-FACS
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-PSCA CAR-293 cells were stained with 100 μL of 3 μg/mL of Biotinylated Human PSCA, His,Avitag (Cat. No. PSA-H82E3) and negative control protein respectively, washed and then followed by PE-SA antibody and analyzed with FACS (Routinely tested).

Synonym Name

PSCA,UNQ206,PRO232

Background

The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored protein, plays an important role in tumorigenesis. The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. PSCA may be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BPX-601 BPX-601 Phase 2 Clinical Bellicum Pancreatic Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms; Esophageal adenocarcinoma; Carcinoma, Pancreatic Ductal Details
124-iodine-labeled PSCA targeting minibody (ImaginAb) Phase 1 Clinical University Of California At Los Angeles Pancreatic Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms Details
GEM3-PSCA GEM3-PSCA Phase 1 Clinical Gemoab Monoconals, Gcp Service International Kidney Neoplasms; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Prostatic Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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