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CD39

CD39 Molecule Information

Name:Ectonucleoside triphosphate diphosphohydrolase 1
Target Synonym:ENTPD1?Ecto-ATPDase 1?CD39?Ecto-ATPase 1?NTPDase 1?Ectonucleoside triphosphate diphosphohydrolase 1?CD_antigen=CD39?Ecto-ATP diphosphohydrolase 1?Ecto-apyrase?Lymphoid cell activation antigen
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase ?

CD39 Molecule Synonym Name

CD39,ENTPD1,NTPDase 1,Entpd1,Ecto-ATPDase 1,Ecto-ATPase 1

CD39 Molecule Background

CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms,  a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.

CD39 References

CD39 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
TTX-030 TTX-030,TTX030 Phase Ⅰ Tizona Therapeutics, Abbvie Cancer Details

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