CD39 Molecule Information
Name：Ectonucleoside triphosphate diphosphohydrolase 1
Target Synonym：ENTPD1?Ecto-ATPDase 1?CD39?Ecto-ATPase 1?NTPDase 1?Ectonucleoside triphosphate diphosphohydrolase 1?CD_antigen=CD39?Ecto-ATP diphosphohydrolase 1?Ecto-apyrase?Lymphoid cell activation antigen
Number of Launched Drugs：0
Number of Drugs in Clinical Trials：1
Lastest Research Phase：Phase ?
CD39 Molecule Synonym Name
CD39,ENTPD1,NTPDase 1,Entpd1,Ecto-ATPDase 1,Ecto-ATPase 1
CD39 Molecule Background
CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.
CD39 Clinical Drug Information
||Tizona Therapeutics, Abbvie