Login Register
icon_bulk_orderBulk order Acrobiosystems for English
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > CD39

CD39

Brief Information

Name:Ectonucleoside triphosphate diphosphohydrolase 1
Target Synonym:CD39 Antigen,CD39,EC 3.6.1.5,NTPDase-1,NTPDase 1,ATPDase,SPG64,EC:3.6.1.5,Ecto-ATPase 1,Lymphoid cell activation antigen,ENTPD1,Ectonucleoside Triphosphate Diphosphohydrolase 1,Ecto-ATPDase 1,Ecto-Apyrase,Ecto-ATP diphosphohydrolase 1,EC 3.6.1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Part of Bioactivity data

CD9-H5253-ELISA
Human CD39, Mouse IgG2a Fc TagHuman CD39, Mouse IgG2a Fc Tag (Cat. No. CD9-H5253) ELISA bioactivity

Immobilized Human CD39, Mouse IgG2a Fc Tag (Cat. No. CD9-H5253) at 1 μg/mL (100 μL/well) can bind Anti-CD39 Antibody, Human IgG1 with a linear range of 0.078-2.5 ng/mL (QC tested).

CD9-C52H3-MALS-HPLC
Cynomolgus CD39, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus CD39, His Tag (Cat. No. CD9-C52H3) is more than 95% and the molecular weight of this protein is around 62-84 kDa verified by SEC-MALS.

Bioactivity-ELISA
Cynomolgus CD39, His TagCynomolgus CD39, His Tag (Cat. No. CD9-C52H3) ELISA bioactivity

Immobilized Anti-CD39 Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind Cynomolgus CD39, His Tag (Cat. No. CD9-C52H3) with a linear range of 2-31 ng/mL (QC tested).

Synonym Name

CD39,ENTPD1,NTPDase 1,Entpd1,Ecto-ATPDase 1,Ecto-ATPase 1

Background

CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms,  a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ES-002 ES-002 Phase 1 Clinical Elpiscience (Shanghai) Biopharma Ltd Solid tumours; Neoplasms Details
ES-002023(Elpiscience Biopharma) Phase 1 Clinical Elpiscience (Shanghai) Biopharma Ltd Solid tumours Details
PUR-001 PUR-001 Purinomia Biotech Inc Details
ES-014 ES-014 Phase 1 Clinical Elpiscience (Shanghai) Biopharma Ltd Solid tumours; Neoplasms Details
SRF-617 SRF-617 Surface Oncology Details
IPH-5201 IPH-5201 Phase 2 Clinical Inserm, Orega Biotech Lung Neoplasms Details
TTX-030 TTX-030 Tizona Therapeutics, Abbvie Inc Details
JS-019 JS-019 Phase 1 Clinical Beijing Enrini Biotechnology Co Ltd Solid tumours; Lymphoma Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America: +1 800-810-0816 (Toll Free)
Asia & Pacific: +86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message