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CD39 Molecule Information

Name:Ectonucleoside triphosphate diphosphohydrolase 1
Target Synonym:EC 3.6.1,CD39 Antigen,CD39,EC,NTPDase-1,NTPDase 1,ATPDase,SPG64,EC:,Ecto-ATPase 1,Lymphoid cell activation antigen,ENTPD1,Ectonucleoside Triphosphate Diphosphohydrolase 1,Ecto-ATPDase 1,Ecto-Apyrase,Ecto-ATP diphosphohydrolase 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CD9-H5253 Human Human CD39 Protein, Mouse IgG2a Fc Tag
CD9-H52H4 Human Human CD39 / ENTPD1 Protein, His Tag (active enzyme)

CD39 Part of Bioactivity data

Human CD39, His TagHuman CD39, His Tag (Cat. No. CD9-H52H4) ELISA bioactivity

Immobilized Human CD39, His Tag (Cat. No. CD9-H52H4) at 1 μg/mL (100 μL/well) can bind Anti-CD39 Antibody, Human IgG1 with a linear range of 0.1-0.8 ng/mL (QC tested).

Human CD39, Mouse IgG2a Fc TagHuman CD39, Mouse IgG2a Fc Tag (Cat. No. CD9-H5253) ELISA bioactivity

Immobilized Human CD39, Mouse IgG2a Fc Tag (Cat. No. CD9-H5253) at 1 μg/mL (100 μL/well) can bind Anti-CD39 Antibody, Human IgG1 with a linear range of 0.2-2 ng/mL (QC tested).

CD39 Molecule Synonym Name

CD39,ENTPD1,NTPDase 1,Entpd1,Ecto-ATPDase 1,Ecto-ATPase 1

CD39 Molecule Background

CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms,  a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.

CD39 References

CD39 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SRF-617 SRF-617 Phase 1 Clinical Surface Oncology Neoplasms Details
IPH-5201 IPH-5201 Phase 1 Clinical Inserm, Orega Biotech Neoplasms Details
TTX-030 TTX-030 Phase 1 Clinical Tizona Therapeutics Lymphoma Details

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