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Complement C5

Brief Information

Name:Complement C5
Target Synonym:C5a,Complement Component 5,ECLZB,Anaphylatoxin C5a Analog,C5a Anaphylatoxin,C5b,C5,Prepro-C5,CPAMD4,Complement C5,C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4,C5D
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:18
Lastest Research Phase:Approved

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Part of Bioactivity data

 Complement C5 ELISA

Immobilized Biotinylated Human Complement C5, His,Avitag (Cat. No. CO5-H82E9) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Monoclonal Anti-Human C5a Human Antibody, Human IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

 Complement C5 ELISA

Immobilized Human Complement C5 Protein, Fc Tag (Cat. No. CO5-H5253) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human C5a Human Antibody, Human IgG1 with a linear range of 0.5-4 ng/mL (QC tested).

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Synonym Name

Complement C5,C5,CPAMD4


Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Pozelimab REGN-3918 Approved Regeneron Pharmaceuticals Inc VEOPOZ United States Protein-Losing Enteropathies Regeneron Pharmaceuticals Inc 2023-08-18 Myasthenia Gravis; Hemoglobinuria, Paroxysmal; Protein-Losing Enteropathies Details
Ravulizumab ALXN-1810; ALXN-1210 Approved Alexion Pharmaceuticals Inc, Xencor Inc Ultomiris United States Hemoglobinuria, Paroxysmal Alexion Pharmaceuticals Inc 2018-12-21 Atypical Hemolytic Uremic Syndrome; Acute Lung Injury; Kidney Failure, Chronic; Amyotrophic Lateral Sclerosis; Renal Insufficiency, Chronic; Pneumonia, Viral; Neuromyelitis Optica; Acute Kidney Injury; Respiratory Distress Syndrome, Adult; Myasthenia Gravis; Thrombotic Microangiopathies; Lupus Nephritis; Heart Diseases; Coronavirus Disease 2019 (COVID-19); Kidney Diseases; Dermatomyositis; Hemoglobinuria, Paroxysmal; Glomerulonephritis, IGA Details
Eculizumab LEX-98; h-5G1.1; 5G1-1; HAL-1 Approved Alexion Pharmaceuticals Inc Soliris, 舒立瑞 United States Hemoglobinuria, Paroxysmal Alexion Pharmaceuticals Inc 2007-03-16 Anemia, Hemolytic, Autoimmune; Diabetes Mellitus; Macular Degeneration; Kidney Failure, Chronic; Guillain-Barre Syndrome; Thrombocytopenia; Urea Cycle Disorders, Inborn; Asthma; Nasopharyngeal Carcinoma; Neuromyelitis Optica; Glomerulonephritis, Membranoproliferative; Pre-Eclampsia; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Rejection of organ transplantation; Infant, Newborn, Diseases; Antiphospholipid Syndrome; Delayed Graft Function; Atypical Hemolytic Uremic Syndrome; Hemoglobinuria, Paroxysmal; Vagus Nerve Diseases; Rejection of renal transplantation; Myasthenia Gravis; End Stage Liver Disease; HELLP Syndrome Details
Avacincaptad pegol ARC-1905; ARC-187 Approved Archemix Corp Zimura, Izervay United States Geographic Atrophy; Macular Degeneration Iveric Bio Inc 2023-08-04 Polypoidal choroidal vasculopathy; Geographic Atrophy; Stargardt Disease; Macular Degeneration Details
Zilucoplan RA-101495-SC; RA-101495 Approved Ra Pharmaceuticals Inc, Ucb Sa ZILBRYSQ, Zilbrysq Japan Myasthenia Gravis Ucb Inc 2023-09-25 Myasthenia Gravis; Hemoglobinuria, Paroxysmal; Coronavirus Disease 2019 (COVID-19); Muscular Diseases; Amyotrophic Lateral Sclerosis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ALXN-5500 ALXN-5500 Phase 1 Clinical Alexion Pharmaceuticals Inc Hemoglobinuria, Paroxysmal Details
Omoprubart CAN-106 Phase 2 Clinical Beihai Kangcheng (Beijing) Pharmaceutical Technology Co Ltd Hemoglobinuria, Paroxysmal; Genetic Diseases, Inborn Details
Cemdisiran ALN-62643; ALN-CC5; AD-62643 Phase 3 Clinical Alnylam Pharmaceuticals Inc Myasthenia Gravis; Hemoglobinuria, Paroxysmal; Glomerulonephritis, IGA; Atypical Hemolytic Uremic Syndrome Details
RLYB-116 RLYB-116 Phase 1 Clinical Rallybio Llc Hematologic Diseases; Immune System Diseases; Inflammation Details
P-014 P014; KP-104 Phase 2 Clinical Kira Pharmaceuticals LLC Hemoglobinuria, Paroxysmal; Glomerulonephritis, IGA; Kidney Diseases; Thrombotic Microangiopathies; Lupus Erythematosus, Systemic; Glomerulonephritis Details
Eculizumab biosimilar (CinnaGen) Phase 3 Clinical Cinnagen Hemoglobinuria, Paroxysmal Details
Eculizumab biosimilar (Biocad) BCD-148 Phase 3 Clinical Biocad Hemoglobinuria, Paroxysmal Details
Gefurulimab TPP-2511; ALXN-1720; CON-9978 Phase 3 Clinical Alexion Pharmaceuticals Inc Myasthenia Gravis; Proteinuria Details
IM-101 IM-101 Phase 1 Clinical ImmunAbs Inc Autoimmune Diseases Details
NM3086 NM3086; NM-3086 Phase 1 Clinical NovelMed Therapeutics Inc Hemoglobinuria, Paroxysmal Details
LP-005 LP-005; RX-001 Phase 1 Clinical Longbio Pharma (Suzhou) Co Ltd Myasthenia Gravis; Hemoglobinuria, Paroxysmal Details
Eculizumab biosimilar (IBC GENERIUM) Phase 3 Clinical Ibc Generium Hemoglobinuria, Paroxysmal; Atypical Hemolytic Uremic Syndrome Details
Nomacopan EV-576; rEV-576; rVA576 Phase 3 Clinical Evolutec Hemoglobinuria, Paroxysmal; Thrombotic Microangiopathies; Pemphigoid, Bullous; Geographic Atrophy; Keratoconjunctivitis Details
Eculizumab biosimilar (Samsung Bioepis) SB-12; AM004; SB12 Phase 3 Clinical Samsung Bioepis Co Ltd Hemoglobinuria, Paroxysmal Details
Eculizumab biosimilar (Amgen) ABP-959 Phase 3 Clinical Amgen Inc Hemoglobinuria, Paroxysmal Details
Eculizumab biosimilar (Turgut Ardika) TUR03; TUR-03 Phase 1 Clinical Turgut Ardika Pty Ltd Details
eculizumab biosimilar(Isu Abxis) ISU-305 Phase 1 Clinical Isu Abxis Co Ltd Hemoglobinuria, Paroxysmal; Atypical Hemolytic Uremic Syndrome Details

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