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IL-15 R alpha

Brief Information

Name:Interleukin-15 receptor subunit alpha
Target Synonym:Interleukin 15 Receptor, Alpha,Interleukin 15 Receptor Alpha Isoform IC3,sIL-15 receptor subunit alpha,IL-15R-Alpha,Interleukin-15 Receptor alpha Subunit,sIL-15RA,sIL-15R-alpha,Interleukin 15 Receptor Alpha Isoform IC2,Interleukin 15 Receptor Alpha Isofor
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

ILA-H5253-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-15 R alpha, Fc Tag (Cat. No. ILA-H5253) inhibits IL-15-dependent proliferation of CTLL-2 cells. The ED50 for this effect is 2.77-4.20 ng/mL (Routinely tested).

ILA-H82F4-ELISA
Biotinylated Human IL-15 R alpha, Fc,AvitagBiotinylated Human IL-15 R alpha, Fc,Avitag (Cat. No. ILA-H82F4) ELISA bioactivity

Immobilized Human IL-15, Tag Free (Cat. No. IL5-H4117) at 2 μg/mL (100 μL/well) can bind Biotinylated Human IL-15 R alpha, Fc,Avitag (Cat. No. ILA-H82F4) with a linear range of 2-39 ng/mL (QC tested).

ILA-M5253-ELISA
Mouse IL-15 R alpha, Fc TagMouse IL-15 R alpha, Fc Tag (Cat. No. ILA-M5253) ELISA bioactivity

Immobilized Human IL-15, Tag Free (Cat. No. IL5-H4117) at 5 μg/mL (100 μL/well) can bind Mouse IL-15 R alpha, Fc Tag (Cat. No. ILA-M5253) with a linear range of 0.6-10 ng/mL (QC tested).

Synonym Name

IL-15 R alpha,CD215,IL15RA,IL-15RA,IL-15R-alpha

Background

IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant interleukin 15 (Beijing Kawin Technology) Phase 1 Clinical Beijing Kawin Technology Share-Holding Co Ltd Details
SO-C101 RLI-15; SO-C101; CYP-0150 Phase 1 Clinical Sotio Microsatellite instability-high cancer; Carcinoma, Hepatocellular; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Thymus Neoplasms; Mesothelioma; Urinary Bladder Neoplasms; Biliary Tract Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Stomach Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Renal Cell; Anus Neoplasms; Squamous Cell Carcinoma of Head and Neck; Ovarian Neoplasms Details
XmAb24306 XmAb-24306; RG-6323; RO-7310729 Phase 1 Clinical Xencor Solid tumours Details
NKTR-255 NKTR-255 Phase 2 Clinical Nektar Therapeutics Squamous Cell Carcinoma of Head and Neck; Multiple Myeloma; Colorectal Neoplasms; Lymphoma, Non-Hodgkin Details
Heterodimeric interleukin 15 NIZ985 Phase 1 Clinical Novartis Pharma Ag Solid tumours; Lymphoma Details
SHR-1501 SHR-1501 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Neoplasms Details
Inbakicept N-803; ALT-803 Phase 3 Clinical Nantkwest, Altor Bioscience Corporation Multiple Myeloma; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Bacterial Infections; Lung Neoplasms; Thyroid Neoplasms; Carcinoma, Squamous Cell; Lymphoma, Non-Hodgkin; Fallopian Tube Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Breast Neoplasms; Microsatellite Instability; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Ovarian Neoplasms; Chordoma; Urinary Bladder Neoplasms; Colonic Neoplasms; Triple Negative Breast Neoplasms; Coronavirus Disease 2019 (COVID-19); Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Renal Cell; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours; HIV Infections; Hematologic Diseases Details

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