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IL-15 R alpha

IL-15 R alpha Molecule Information

Name:Interleukin-15 receptor subunit alpha
Target Synonym:Interleukin 15 Receptor, Alpha,Interleukin 15 Receptor Alpha Isoform IC3,sIL-15 receptor subunit alpha,IL-15R-Alpha,Interleukin-15 Receptor alpha Subunit,sIL-15RA,sIL-15R-alpha,Interleukin 15 Receptor Alpha Isoform IC2,Interleukin 15 Receptor Alpha Isofor
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 3 Clinical

IL-15 R alpha Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
ILA-H82F4 Human Biotinylated Human IL-15 R alpha / CD215 Protein, Fc,Avitag™
ILA-H5253 Human Human IL-15 R alpha / CD215 Protein, Fc Tag

IL-15 R alpha Part of Bioactivity data

ILA-H5253-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-15 R alpha, Fc Tag (Cat. No. ILA-H5253) inhibits IL-15-dependent proliferation of CTLL-2 cells. The ED50 for this effect is 2.77-4.20 ng/mL (Routinely tested).

Human IL-15 R alpha, Fc TagHuman IL-15 R alpha, Fc Tag (Cat. No. ILA-H5253) ELISA bioactivity

Immobilized Human IL-15 R alpha, Fc Tag (Cat. No. ILA-H5253) at 2 μg/mL (100 μL/well) can bind Biotinylated Human IL-15, Fc,Avitag (Cat. No. IL5-H82F3) with a linear range of 2-78 ng/mL (QC tested).

Biotinylated Human IL-15 R alpha, Fc,AvitagBiotinylated Human IL-15 R alpha, Fc,Avitag (Cat. No. ILA-H82F4) ELISA bioactivity

Immobilized Human IL-15, Tag Free (Cat. No. IL5-H4117) at 2 μg/mL (100 μL/well) can bind Biotinylated Human IL-15 R alpha, Fc,Avitag (Cat. No. ILA-H82F4) with a linear range of 2-39 ng/mL (QC tested).

IL-15 R alpha Molecule Synonym Name

IL-15 R alpha,CD215,IL15RA,IL-15RA,IL-15R-alpha

IL-15 R alpha Molecule Background

IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL)-15 superagonist/IL-15 receptor ? fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

IL-15 R alpha References

IL-15 R alpha Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SHR-1501 SHR-1501 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Neoplasms Details
Recombinant interleukin 15 (Beijing Kawin Technology) Phase 1 Clinical Beijing Kawin Technology Share-Holding Co Ltd Details
SO-C101 RLI-15; SO-C101; CYP-0150 Phase 1 Clinical Sotio Microsatellite instability-high cancer; Carcinoma, Hepatocellular; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Thymus Neoplasms; Mesothelioma; Urinary Bladder Neoplasms; Biliary Tract Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Stomach Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Renal Cell; Anus Neoplasms; Squamous Cell Carcinoma of Head and Neck; Ovarian Neoplasms Details
NKTR-255 NKTR-255 Phase 2 Clinical Nektar Therapeutics Squamous Cell Carcinoma of Head and Neck; Multiple Myeloma; Colorectal Neoplasms; Lymphoma, Non-Hodgkin Details
XmAb24306 XmAb-24306; RG-6323; RO-7310729 Phase 1 Clinical Xencor Solid tumours Details
Heterodimeric interleukin 15 NIZ985 Phase 1 Clinical Novartis Pharma Ag Solid tumours; Lymphoma Details
Inbakicept N-803; ALT-803 Phase 3 Clinical Nantkwest, Altor Bioscience Corporation Chordoma; Uterine Cervical Neoplasms; Bacterial Infections; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Lung Neoplasms; Carcinoma, Squamous Cell; Thyroid Neoplasms; Lymphoma, Non-Hodgkin; Peritoneal Neoplasms; Colorectal Neoplasms; Microsatellite Instability; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Ovarian Neoplasms; Urinary Bladder Neoplasms; Multiple Myeloma; Small Cell Lung Carcinoma; Colonic Neoplasms; Coronavirus Disease 2019 (COVID-19); Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Carcinoma, Merkel Cell; Solid tumours; Hematologic Diseases; HIV Infections Details

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