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IL-5

IL-5 Molecule Information

Name:Interleukin-5
Target Synonym:T-cell replacing factor,IL5,Interleukin 5,Eosinophil Differentiation Factor,Colony-Stimulating Factor, Eosinophil,B-Cell Differentiation Factor I,Interleukin-5,IL-5,TRF,Interleukin 5 (Colony-Stimulating Factor, Eosinophil),B Cell Differentiation Factor I,
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

IL-5 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IL5-R52H4 Rabbit Rabbit IL-5 Protein, His Tag
IL5-R52H4-structure
IL5-R52H4-sds
IL5-R52H4-elisa_1
IL5-H82Q5 Human Biotinylated Human IL-5 Protein, His,Avitag™
IL5-H82Q5-structure
IL5-H82Q5-sds
IL5-H82Q5-elisa_1
IL5-H52H3 Human Human IL-5 Protein, His Tag
IL5-H52H3-structure
IL5-H52H3-sds
IL5-H52H3-elisa_1

IL-5 Part of Bioactivity data

IL5-H52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-5, His Tag (Cat. No. IL5-H52H3) on NTA Biosensor, can bind Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5259) with an affinity constant of 4.63 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL5-H82Q5-ELISA
Biotinylated Human IL-5, His,AvitagBiotinylated Human IL-5, His,Avitag (Cat. No. IL5-H82Q5) ELISA bioactivity

Immobilized Biotinylated Human IL-5, His,Avitag (Cat. No. IL5-H82Q5) at 1 μg/mL (100 μL/well) on Recombinant Streptavidin (Cat. No. STN-N5116 ) precoated (0.5 μg/well) plate, can bind Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5259) with a linear range of 5-78 ng/mL (QC tested).

IL-5 Molecule Synonym Name

IL-5,TRF,IL5,Interleukin-5

IL-5 Molecule Background

Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL-5 are mepolizumab and reslizumab.

IL-5 References

IL-5 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Reslizumab TRFK-5; CDP-835; SCH-5570; CEP-38072; CTx-55700; SCH-55700 Approved Teva Pharmaceutical Industries Ltd Cinqair, Cinquil, Cinqaero EU Asthma s:7:"Teva Bv"; 2016-03-23 Pulmonary Eosinophilia; Eosinophilic Esophagitis; Asthma Details
Mepolizumab SB-240563; 240563 Approved Glaxosmithkline Plc Nucala, Bosatria United States Hypereosinophilic Syndrome s:19:"Glaxosmithkline Plc"; 2015-11-04 Hypereosinophilic Syndrome; Granulomatosis with Polyangiitis; Churg-Strauss Syndrome; Nasal Polyps; Eosinophilic Esophagitis; Asthma; Eosinophilic Granuloma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details

IL-5 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
long-acting anti-IL-5 mAb (GSK) Phase 1 Clinical Glaxosmithkline Plc Asthma Details
GSK3511294 Phase 3 Clinical Glaxosmithkline Plc Asthma Details
LP-0058 LP-0058; LEO-32731 Phase 2 Clinical Leo Pharma Inc Drug-Related Side Effects and Adverse Reactions; Psoriasis; Dermatitis, Atopic Details
SHR-1703 SHR-1703 Phase 1 Clinical Suzhou Suncadia Biopharmaceuticals Co Ltd, Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd Asthma Details
Recombinant anti-IL-5 humanized monoclonal antibody (Shanghai CP Guojian) 610 Phase 1 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Autoimmune Diseases; Asthma Details

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