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IL-5 Molecule Information

Target Synonym:IL-5;IL5;TRF;T-cell replacing factor;Eosinophil differentiation factor;B-cell differentiation factor I;Interleukin-5
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
IL5-H82Q5 Human Biotinylated Human IL-5 Protein, His,Avitag™
IL5-H52H3 Human Human IL-5 Protein, His Tag

IL-5 Part of Bioactivity data


Loaded Human IL-5, His Tag (Cat. No. IL5-H52H3) on NTA Biosensor, can bind Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5259) with an affinity constant of 4.63 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Human IL-5, His TagHuman IL-5, His Tag (Cat. No. IL5-H52H3) ELISA bioactivity

Immobilized Human IL-5, His Tag (Cat. No. IL5-H52H3) at 5 μg/mL (100 μL/well) can bind Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5259) with a linear range of 0.02-0.313 μg/mL (QC tested).

IL-5 Molecule Synonym Name


IL-5 Molecule Background

Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL-5 are mepolizumab and reslizumab.

IL-5 References

IL-5 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Mepolizumab SB-240563; 240563,SB240563 Approved GlaxoSmithKline NUCALA fda Asthma GLAXOSMITHKLINE LLC 2015-11-04 Eosinophilic granulomatosis, Asthma Details
Reslizumab CDP-835; CEP-38072; CTx-55700; SCH-5570; SCH-55700; TRFK-5,CDP835; CEP38072; CTx55700; SCH5570; SCH55700; TRFK5 Approved Teva CINQAIR fda Asthma TEVA RESPIRATORY LLC 2016-03-23 Asthma Details

IL-5 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GCC-AP0341 GCC-AP0341,GCCAP0341,GCC AP0341 Preclinical Mitsubishi Tanabe Pharma Bronchial asthma Details
SHR-1703 SHR-1703 Phase Ⅰ Shanghai Hengrui, Jiangsu Hengrui Medicine, Suzhou Shengdiya Unspecified Details
LP-0058 LP-0058; LEO-32731,LP0058,LEO32731 Phase Ⅱ Leo Pharma Psoriasis, Atopic dermatitis Details
Recombinant anti-IL-5 humanized monoclonal antibody (Shanghai CP Guojian) 610 Phase Ⅰ Shanghai CP Guojian Autoimmune diseases, Asthma Details

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