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Brief Information

Name:Tyrosine-protein kinase receptor FLT3
Target Synonym:EC:,CD135 Antigen,CD135,STK1,Growth Factor Receptor Tyrosine Kinase Type III,Fms-Related Tyrosine Kinase 3,Fetal Liver Kinase 2,Fetal Liver Kinase-2,EC,fms-Like Tyrosine Kinase 3,Receptor-type tyrosine-protein kinase FLT3,FLT3,FLT-3,FLK2,STK-1,FL cytokine receptor,Fms Related Tyrosine Kinase 3,Stem Cell Tyrosine Kinase 1,FLK-2,Fms Related Receptor Tyrosine Kinase 3,EC 2.7.10
Number of Launched Drugs:13
Number of Drugs in Clinical Trials:46
Lastest Research Phase:Approved


Project Name Modality Therapeutic Area Indications Stage Right Available
FLT3 Inhibition Small molecule Oncology/Cancer AML Phase III Global
FMS-like tyrosine kinase 3(FLT3)inhibitor Small molecule Oncology/Cancer Advanced/Metastatic Malignant Solid Tumors,Relapsed/Refractory Acute Myeloid Leukemia with FLT3 Mutation Phase III Global

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Part of Bioactivity data

 Flt-3 ELISA

Immobilized Human Flt-3 Ligand, premium grade (Cat. No. FLL-H5218) at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human Flt-3, Fc Tag (Cat. No. FL3-HF255) with a linear range of 0.2-13 ng/mL (QC tested).

Flt-3 MALS images

The purity of Cynomolgus Flt-3 Protein, His Tag (Cat. No. FL3-C52H5) is more than 90% and the molecular weight of this protein is around 75-95 kDa verified by SEC-MALS.

Synonym Name



Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Quizartinib AC-010220; ASP-2689; AC-220 Approved Ambit Biosciences Co Vanflyta Japan Leukemia, Myeloid, Acute Daiichi Sankyo Co Ltd 2019-06-18 Leukemia; Leukemia, Myeloid; Solid tumours; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute Details
Brigatinib AP-26113 Approved Ariad Pharmaceuticals Inc Alunbrig, ALUNBRIG United States Carcinoma, Non-Small-Cell Lung Takeda Pharmaceuticals U.S.A. Inc 2017-04-28 Solid tumours; Ependymoma; Carcinoma; Neoplasms; Neurofibromatosis 2; Small Cell Lung Carcinoma; Myofibroma; Lymphoma, Large-Cell, Anaplastic; Brain metastases; Lung Neoplasms; Granuloma, Plasma Cell; Carcinoma, Non-Small-Cell Lung; Sarcoma, Kaposi; Neurilemmoma; Meningioma; Neuroma, Acoustic Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef United States Idiopathic Pulmonary Fibrosis Boehringer Ingelheim Gmbh 2014-10-15 Lung Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Adenocarcinoma, Clear Cell; systemic sclerosis-associated interstitial lung disease; Colorectal Neoplasms; Peritoneal Neoplasms; Gliosarcoma; Hepatic Insufficiency; Astrocytoma; Genital Neoplasms, Female; Silicosis; Sarcoma; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Appendiceal Neoplasms; Leukemia, Myeloid, Acute; Uterine Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Adenocarcinoma; Carcinoma, Endometrioid; Scleroderma, Systemic; Telangiectasia, Hereditary Hemorrhagic; Solid tumours; Rejection of lung transplantation; Carcinoma, Renal Cell; Radiation Pneumonitis; Esophageal Neoplasms; Carcinoid Tumor; Endometrial Stromal Tumors; Idiopathic Pulmonary Fibrosis; Neoplasms; Ovarian Neoplasms; Glioblastoma; Colonic Neoplasms; Small Cell Lung Carcinoma; Pulmonary Fibrosis; Lung Diseases, Interstitial; Oligodendroglioma; Multiple Myeloma; Mesothelioma; Asbestosis; Neuroendocrine Tumors Details
Vorolanib X-82; EYP-1901; CM-082 Approved Tyrogenex Inc 伏美纳 Mainland China Carcinoma, Renal Cell Betta Pharmaceuticals Co Ltd 2023-06-07 Diabetic macular oedema; Carcinoma, Non-Small-Cell Lung; Melanoma; Macular Degeneration; Carcinoma, Hepatocellular; Diabetic Retinopathy; Choroidal Neovascularization; Adenocarcinoma; Retinal Degeneration; Leukemia, Myeloid, Acute; Eye Diseases; Solid tumours; Wet Macular Degeneration; Retinal Diseases; Small Cell Lung Carcinoma; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Kidney Neoplasms Details
Gilteritinib Fumarate ASP-2215 hemifumarate; ASP-2215; 66D-92MGC8M (UNII code) Approved Astellas Pharma Inc Xospata Japan Leukemia, Myeloid, Acute Astellas Pharma Inc 2018-09-21 Solid tumours; Renal Insufficiency; Hepatic Insufficiency; Lung Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
pacritinib citrate SB-1518; ONX-0803 Approved S*BIO Pte Ltd, Concert VONJO United States Primary Myelofibrosis Cti Biopharma Corp 2022-02-28 Hepatic Insufficiency; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Thrombocythemia, Essential; Sarcoma, Kaposi; Thrombocytopenia; Lymphoma, T-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Myelomonocytic, Juvenile; Lymphoma, T-Cell, Cutaneous; Leukemia, Myeloid, Acute; Waldenstrom Macroglobulinemia; Colorectal Neoplasms; Lymphoproliferative Disorders; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Lymphoma, T-Cell, Peripheral; Castleman Disease; Primary Myelofibrosis; Coronavirus Infections; Lymphoma, Mantle-Cell; Coronavirus Disease 2019 (COVID-19); Hodgkin Disease; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Chronic; Graft vs Host Disease; Myelodysplastic Syndromes; Polycythemia Vera; Lymphoma, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia Details
Fedratinib TG-101348; SAR-302503 Approved Sanofi Inrebic United States Primary Myelofibrosis Bristol-Myers Squibb Company 2019-08-16 Hematologic Neoplasms; Solid tumours; Polycythemia Vera; Kidney Diseases; Neoplasms; Myelodysplastic Syndromes; Myeloproliferative Disorders; Leukemia, Neutrophilic, Chronic; Primary Myelofibrosis; Hepatic Insufficiency; Splenomegaly; Thrombocythemia, Essential Details
Ponatinib Hydrochloride AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534 Approved Ariad Iclusig United States Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic Ariad Pharmaceuticals Inc 2012-12-14 Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Biphenotypic, Acute; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Chronic-Phase; Philadelphia Chromosome; Common Bile Duct Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Medullary thyroid cancer (MTC); Leukemia, Myelogenous, Chronic; Blast Crisis; Glioblastoma; Leukemia, Myelomonocytic, Chronic; Adenocarcinoma of Lung; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Hematologic Neoplasms; Leukemia, Myeloid, Accelerated Phase; Leukemia; Head and Neck Neoplasms Details
Sunitinib Malate PNU-290940AD; PHA-290940AD; SCAI-003; GB-102; PNU-290940; SU-011248-L-malate salt; PHA-290940; SU-010398; SU-11248 Approved Pfizer Inc 索坦, Sutent United States Carcinoma, Renal Cell; Gastrointestinal Stromal Tumors Cppi Cv 2006-01-26 Solid tumours; Fibromatosis, Aggressive; Ovarian Neoplasms; Kidney Neoplasms; Leukemia, Myelogenous, Chronic; Head and Neck Neoplasms; Leiomyosarcoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; HIV Infections; Leukemia, Myeloid, Accelerated Phase; Leukemia; Fibrosarcoma; Teratoma; Liver Neoplasms; Ependymoma; Lymphoma, T-Cell, Peripheral; Intestinal Neoplasms; Histiocytoma, Malignant Fibrous; Carcinoma, Renal Cell; Hemangioblastoma; Carcinoma, Islet Cell; Carcinoma; Pheochromocytoma; Stomach Neoplasms; Pelvic Neoplasms; Esophageal Neoplasms; Leukemia, Hairy Cell; Polycythemia Vera; Abdominal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thoracic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Carcinoma, Ovarian Epithelial; Glioblastoma; Neurofibromatoses; Small Cell Lung Carcinoma; Adenoma, Islet Cell; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Myelodysplastic Syndromes; Hodgkin Disease; Leukemia, Myelomonocytic, Chronic; Carcinoma, Papil Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasm Metastasis; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Neurofibrosarcoma; Giant Cell Tumors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neurofibroma, Plexiform; Sarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours; Breast Neoplasms; Neoplasms; Arthritis, Rheumatoid; Hodgkin Disease; Glioblastoma; Pancreatic Neoplasms; Synovitis, Pigmented Villonodular; Squamous Cell Carcinoma of Head and Neck; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Giant Cell Tumor of Tendon Sheath Details
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx United States Carcinoma, Neuroendocrine; Thyroid Neoplasms Exelixis Inc 2012-11-29 Urethral Neoplasms; Leukemia, Myeloid, Acute; Thyroid Neoplasms; Gliosarcoma; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Peritoneal Neoplasms; Bile Duct Neoplasms; Sarcoma, Clear Cell; Uterine Neoplasms; Adenocarcinoma, Clear Cell; Sarcoma, Ewing; Carcinoma, Adenosquamous; Breast Neoplasms; Neurofibroma, Plexiform; Osteosarcoma; Prostatic Neoplasms; Sarcoma; Medullary thyroid cancer (MTC); Carcinoma, Hepatocellular; Melanoma; Paraganglioma; Meningioma; Neoplasms, Germ Cell and Embryonal; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Carcinoma, Endometrioid; Thyroid Cancer, Papillary; Brain Neoplasms; Carcinoma, Neuroendocrine; Sarcoma, Alveolar Soft Part; Lymphoma; Fallopian Tube Neoplasms; Brain metastases; Glioma; Endometrial Neoplasms; Carcinoma, Squamous Cell; Carcinoid Tumor; Glioblastoma; Skin Neoplasms; Neoplasms; Carcinoma, Papillary; Hepatoblastoma; Pheochromocytoma; Pain; Rejection of liver transplantation; Carcinoma, Renal Cell; Pancreatic neuroendocrine tumors Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc Nexavar, 多吉美 United States Carcinoma, Renal Cell Bayer Healthcare Pharmaceuticals Inc 2005-12-01 Liver Neoplasms; Kidney Neoplasms; Recurrence; Ovarian Neoplasms; Leukemia, Myelogenous, Chronic; Lymphoma, T-Cell, Peripheral; Leukemia, Erythroblastic, Acute; Rhabdomyosarcoma; Lymphoma, B-Cell, Marginal Zone; Fibromatosis, Aggressive; Head and Neck Neoplasms; Solid tumours; Leiomyosarcoma; Leukemia, Myeloid; Carcinoma, Renal Cell; Carcinoma; Vipoma; Esophageal Neoplasms; Hemangiosarcoma; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Carcinoid Tumor; Histiocytoma, Malignant Fibrous; Carcinoma, Islet Cell; Insulinoma; Stomach Neoplasms; Neoplasms; Kidney Diseases; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Thyroid Carcinoma, Anaplastic; Myelodysplastic Syndromes; Glioblastoma; Pancreatic Neoplasms; Leukemia, Myelomonocytic, Chronic; Carcinoma, Ovarian Epithelial; Leukemia, Myelomonocytic, Acute; Wilms Tumor; Lymphomatoid Granulomatosis; Colonic Neoplasms; Hypertension, Portal; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Multiple Endo Details
Midostaurin PKC-412; PKC-412A; CGP-41231; CGP-41251 Approved Novartis Pharma Ag Rydapt United States Mastocytosis, Systemic; Leukemia, Mast-Cell; Hematologic Neoplasms; Leukemia, Myeloid, Acute Novartis Pharmaceuticals Corp 2017-04-28 Leukemia; Hematologic Neoplasms; Mastocytosis, Systemic; Myelodysplastic Syndromes; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
XY-0206 XY-0206 Phase 3 Clinical Nanjing University Of Chinese Medicine Solid tumours; Leukemia, Myeloid, Acute Details
Clifutinib Besylate Phase 3 Clinical Guangdong Dongyangguang Pharmaceutical Co Ltd Leukemia, Myeloid, Acute Details
KC1036 KC1036; KC-1036 Phase 3 Clinical Beijing Konruns Pharmaceutical Co Ltd Hematologic Neoplasms; Solid tumours; Digestive System Neoplasms; Sarcoma, Ewing; Thymus Neoplasms; Esophageal Squamous Cell Carcinoma; Adenocarcinoma; Neoplasm Metastasis Details
SKLB-1028 SKLB-1028 Phase 3 Clinical Sichuan University, CSPC Pharmaceutical Group Ltd Solid tumours; Leukemia, Promyelocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute Details
Lestaurtinib SPM-924; A-154475.0; KT-5555; SP-924; CEP-701 Phase 3 Clinical Kyowa Hakko Kirin Co Ltd Leukemia, Myeloid; Bone Marrow Neoplasms; Leukemia; Polycythemia Vera; Prostatic Neoplasms; Psoriasis; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neuroblastoma; Primary Myelofibrosis; Leukemia, Myeloid, Acute; Thrombocythemia, Essential Details
HEC-73543 HEC-73543 Phase 3 Clinical Hec Pharm Co Ltd Leukemia, Myeloid, Acute Details
Crenolanib Besylate CP-868596-26; IND-112201; CP-868596; ARO-002; ARO-002-26 Phase 3 Clinical Pfizer Inc Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Glioma Details
HYML-122 HYML-122; CHMFL-FLT3-122 Phase 2 Clinical Hefei Academy Of Physical Sciences, Chinese Academy Of Sciences, Hefei Cosource Pharmaceuticals Leukemia, Myeloid, Acute Details
Ningetinib Tosylate CT-053-PTSA; CT-053 Phase 2 Clinical Hec Pharm Co Ltd Intestinal Neoplasms; Solid tumours; Carcinoma, Renal Cell; Stomach Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
MRX-2843 UNC-2371; UNC-2025; MRX-2843 Phase 2 Clinical University Of North Carolina At Chapel Hill Leukemia; Solid tumours; Neoplasms; Pathologic Processes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lung Neoplasms; Leukemia, Myeloid, Acute; Neoplastic Processes; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Emavusertib AU-4948; CA-4948 Phase 2 Clinical Aurigene Anemia; Stomach Neoplasms; Esophageal Neoplasms; Myelodysplastic Syndromes; Pancreatic Neoplasms; Digestive System Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Pancreatic Ductal; Lymphoma, Non-Hodgkin; Gastrointestinal Neoplasms; Melanoma Details
Zotiraciclib TG-02; SB-1317 Phase 2 Clinical Syncore Biotechnology Co Ltd Glioblastoma; Neoplasms; Brain Neoplasms; Astrocytoma; Gliosarcoma; Glioma; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Hepatocellular Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Srl Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
MAX-40279 MAX-40279-001; Max-40279; MAX-40279-01; MAX-4 Phase 2 Clinical Maxinovel Pharmaceuticals Co Ltd Solid tumours; Leukemia; Esophageal Neoplasms; Stomach Neoplasms; Idiopathic Pulmonary Fibrosis; Myelodysplastic Syndromes; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Neoplasm Metastasis Details
Merestinib 5OGS5K699E; LY-2801653 Phase 2 Clinical Eli Lilly And Company Biliary Tract Neoplasms; Skin Melanoma; Bone metastases; Solid tumours; Neoplasms; Pancreatic Neoplasms; Microsatellite instability-high cancer; Lymphoma, Mantle-Cell; Breast Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Gallbladder Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Fms-like tyrosine kinase 3 ligand (Celldex Therapeutics) CDX-301 Phase 2 Clinical Amgen Inc Sarcoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Melanoma; Leukemia, Myeloid, Acute; Carcinoma, Squamous Cell; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Osteosarcoma; Skin Melanoma; Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Myelodysplastic Syndromes; Hodgkin Disease; Carcinoma, Renal Cell; Carcinoma, Merkel Cell; Squamous Cell Carcinoma of Head and Neck; Leukemia, Myelogenous, Chronic Details
Tuspetinib HM-43239 Phase 2 Clinical Hanmi Pharmaceutical Co Ltd Leukemia, Myeloid, Acute Details
Flysyn 4G8-SDIEM Phase 2 Clinical Synimmune Gmbh Leukemia, Myeloid, Acute Details
Glesatinib MGCD-265; MG-90265X; 7Q29OXD98N; MG-90265H9; MG-90265gly; MG-90265 Phase 2 Clinical Mirati Therapeutics Inc Neoplasms; Carcinoma, Non-Small-Cell Lung Details
FF-10101 FF-10101; FF-10101-01; FF-10101 succinate Phase 2 Clinical Fujifilm Corp Leukemia, Myeloid, Acute Details
Sorafenib Tosylate/Comekibart MG-D-1609 Phase 2 Clinical Metagone Biotech Inc Solid tumours Details
Anti-FLT3 CAR-T Cell Therapy (PersonGen Biomedicine) TAA05 Phase 2 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Leukemia, Myeloid, Acute Details
Flonoltinib maleate Phase 2 Clinical Chengdu Zenitar Biomedical Technology Co Ltd Polycythemia Vera; Alopecia Areata; Myeloproliferative Disorders; Primary Myelofibrosis; Lymphohistiocytosis, Hemophagocytic; Thrombocythemia, Essential Details
EP-0042 EP-0042 Phase 2 Clinical Ellipses Pharma Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
MEN-1703 SEL-24-1; MEN-1703; SEL24/MEN1703; SEL24; SEL-24; SEL-24-B489 Phase 2 Clinical Ryvu Therapeutics Sa Leukemia, Myeloid, Acute Details
FN-1501 FN-1501; LT-171-861 Phase 2 Clinical China Pharmaceutical University, Shanghai Fosun Pharmaceutical Industrial Development Co Ltd Solid tumours; Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Hepatocellular Details
Mivavotinib TAK-659; CB-659 Phase 1 Clinical Takeda Pharmaceutical Co Ltd Lymphoma, B-Cell; Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Plasmablastic Lymphoma; Lymphoma, Follicular; Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details
Emirodatamab AMG-427 Phase 1 Clinical Amgen Inc Leukemia, Myeloid, Acute Details
E-6201 E-6201 Phase 1 Clinical Eisai Co Ltd Solid tumours; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Psoriasis; Brain metastases; Leukemia, Myeloid, Acute; Melanoma Details
SENTI-202 SENTI-202 Phase 1 Clinical Senti Biosciences Inc Hematologic Neoplasms; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
ETH-155008 ETH-155008 Phase 1 Clinical Yunnan Shengke Pharmaceutical Co Ltd Leukemia; Leukemia, Promyelocytic, Acute; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute Details
CLN-049 CLN-049 Phase 1 Clinical University Of Tubingen, German Cancer Research Center (Dkfz) Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
QBH-196 QBH-196 Phase 1 Clinical Shenyang Pharmaceutical University Solid tumours; Stomach Neoplasms Details
ETN-101 ETN101; ETN-101; MBP-11901 Phase 1 Clinical Etnova Therapeutics Corp Liver Neoplasms; Carcinoma, Hepatocellular Details
Lomonitinib Phase 1 Clinical Eilean Therapeutics LLC Details
KME-0584 KME-0584 Phase 1 Clinical National Center For Advancing Translational Sciences, Cincinnati Children'S Hospital Medical Center Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Lomonitinib ZE46-0134; ZE-46-0134; ZE-460134 Phase 1 Clinical Eilean Therapeutics LLC Leukemia, Promyelocytic, Acute; Leukemia, Myeloid, Acute Details
ETH-155036 ETH-155036; ETH155036 Phase 1 Clinical Shengke Pharmaceutical (Jiangsu) Co Ltd Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Nintedanib Solution for Inhalation AP02; AP-02 Phase 1 Clinical Avalyn Pharma Inc Idiopathic Pulmonary Fibrosis Details
BMF-500 BMF-500 Phase 1 Clinical Biomea Fusion Inc Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute Details
TT-00973 TT-00973 Phase 1 Clinical TransThera Sciences (Nanjing) Inc Solid tumours Details
PHI-101 PHI-101; PHI-101-002; PHI-101-003 Phase 1 Clinical Pharos iBio Co Ltd Ovarian Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute Details
LNK-01002 LNK01002 Phase 1 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Hematologic Neoplasms; Polycythemia Vera; Myeloproliferative Disorders; Primary Myelofibrosis; Leukemia, Myeloid, Acute Details
SKI-G-801 G-801; SKI-G-801; G-749 Hydrochloride Phase 1 Clinical Oscotec Inc Solid tumours; Leukemia, Myeloid, Acute Details
Luxeptinib CG-806; CG-026806 Phase 1 Clinical Crystalgenomics Inc, Aptose Myelodysplastic Syndromes; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Leukemia, Lymphocytic, Chronic, B-Cell Details
Sorafenib/MG-005 MGD-1509; MG-D-1509 Tri-Service General Hospital, Metagone Biotech Inc Details

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