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Your Position: Home > Flt-3

Flt-3

Brief Information

Name:Tyrosine-protein kinase receptor FLT3
Target Synonym:EC:2.7.10.1,CD135 Antigen,CD135,STK1,Growth Factor Receptor Tyrosine Kinase Type III,Fms-Related Tyrosine Kinase 3,Fetal Liver Kinase 2,Fetal Liver Kinase-2,EC 2.7.10.1,fms-Like Tyrosine Kinase 3,Receptor-type tyrosine-protein kinase FLT3,FLT3,FLT-3,FLK2,STK-1,FL cytokine receptor,Fms Related Tyrosine Kinase 3,Stem Cell Tyrosine Kinase 1,FLK-2,Fms Related Receptor Tyrosine Kinase 3,EC 2.7.10
Number of Launched Drugs:12
Number of Drugs in Clinical Trials:40
Lastest Research Phase:Approved

Licensing

Project item Indications Research phase Cooperation demands
BHE202209 FLT3-ITD mutation AML Phase 3, IP in 16 countries License-out or co-development

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Cat. No. Species Product Description Structure Purity Feature
FL3-C52H5 Cynomolgus Cynomolgus Flt-3 / Flk-2 Protein, His Tag (MALS verified)
FL3-C52H5-sds
FL3-HF255 Human FITC-Labeled Human Flt-3 / Flk-2 Protein, Fc Tag
FL3-HF255-structure
FL3-HF255-sds
FL3-H82E3 Human Biotinylated Human Flt-3 / Flk-2 Protein, His,Avitag™ (MALS verified)
FL3-H82E3-structure
FL3-H82E3-sds
FL3-H52H6 Human Human Flt-3 / Flk-2 Protein, His Tag (MALS verified)
FL3-H52H6-structure
FL3-H52H6-sds
FL3-M52H6 Mouse Mouse Flt-3 / Flk-2 Protein, His Tag
FL3-M52H6-structure
FL3-M52H6-sds
FL3-H5258 Human Human Flt-3 / Flk-2 Protein, Fc Tag (MALS verified)
FL3-H5258-structure
FL3-H5258-sds
ACRO Quality

Part of Bioactivity data

FL3-H82E3-ELISA
Flt-3 ELISA

Immobilized Human Flt-3 Ligand, His Tag (Cat. No. FLL-H5223) at 1 μg/mL (100 μL/well) can bind Biotinylated Human Flt-3, His,Avitag (Cat. No. FL3-H82E3) with a linear range of 0.039-1.25 μg/mL (QC tested).

Protocol
FL3-C52H5-MALS-HPLC
Flt-3 MALS images

The purity of Cynomolgus Flt-3 Protein, His Tag (Cat. No. FL3-C52H5) is more than 90% and the molecular weight of this protein is around 75-95 kDa verified by SEC-MALS.

Synonym Name

Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3

Background

Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Midostaurin PKC-412; PKC-412A; CGP-41231; CGP-41251 Approved Novartis Pharma Ag Rydapt United States Leukemia, Myeloid, Acute; Mastocytosis Novartis Europharm Ltd 2017-04-28 Hematologic Neoplasms; Leukemia; Mastocytosis, Systemic; Myelodysplastic Syndromes; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis Details
Fedratinib TG-101348; SAR-302503 Approved Sanofi Inrebic United States Primary Myelofibrosis; Splenomegaly Bristol Myers Squibb Srlcompany 2019-08-16 Hematologic Neoplasms; Solid tumours; Polycythemia Vera; Kidney Diseases; Myeloproliferative Disorders; Neoplasms; Leukemia, Neutrophilic, Chronic; Primary Myelofibrosis; Hepatic Insufficiency; Splenomegaly; Thrombocythemia, Essential Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Prostatic Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Melanoma; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Giant Cell Tumors; Neurofibroma, Plexiform; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neurofibrosarcoma; Sarcoma; Ovarian Neoplasms; Breast Neoplasms; Arthritis, Rheumatoid; Pancreatic Neoplasms; Glioblastoma; Neoplasms; Hodgkin Disease; Synovitis, Pigmented Villonodular; Squamous Cell Carcinoma of Head and Neck; Leukemia, Promyelocytic, Acute; Giant Cell Tumor of Tendon Sheath; Solid tumours Details
Ponatinib Hydrochloride AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534 Approved Ariad Iclusig United States Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic, BCR-ABL Positive Otsuka Holdings Co Ltd 2012-12-14 Blast Crisis; Carcinoma, Non-Small-Cell Lung; Leukemia, Biphenotypic, Acute; Thyroid Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic-Phase; Gastrointestinal Stromal Tumors; Philadelphia Chromosome; Medullary thyroid cancer (MTC); Common Bile Duct Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic; Glioblastoma; Leukemia, Myelomonocytic, Chronic; Neoplasms; Small Cell Lung Carcinoma; Adenocarcinoma of Lung; Head and Neck Neoplasms; Solid tumours; Leukemia, Myeloid, Accelerated Phase; Leukemia; Hematologic Neoplasms Details
Gilteritinib Fumarate ASP-2215 hemifumarate; ASP-2215; 66D-92MGC8M (UNII code) Approved Astellas Pharma Inc Xospata Japan Leukemia, Myeloid, Acute Astellas Pharmaceutical (China) Co Ltd 2018-09-21 Solid tumours; Renal Insufficiency; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc Nexavar, 多吉美 United States Thyroid Neoplasms Bayer AG 2005-12-01 Liver Neoplasms; Leukemia, Myeloid; Lymphoma, B-Cell, Marginal Zone; Rhabdomyosarcoma; Head and Neck Neoplasms; Leukemia, Myelogenous, Chronic; Fibromatosis, Aggressive; Leiomyosarcoma; Kidney Neoplasms; Leukemia, Erythroblastic, Acute; Solid tumours; Lymphoma, T-Cell, Peripheral; Ovarian Neoplasms; Recurrence; Carcinoma, Renal Cell; Esophageal Neoplasms; Vipoma; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Histiocytoma, Malignant Fibrous; Carcinoma, Islet Cell; Hemangiosarcoma; Carcinoid Tumor; Carcinoma; Insulinoma; Stomach Neoplasms; Neoplasms; Pancreatic Neoplasms; Multiple Endocrine Neoplasia Type 2a; Hypertension, Portal; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Thyroid Carcinoma, Anaplastic; Myelodysplastic Syndromes; Glioblastoma; Carcinoma, Ovarian Epithelial; Leukemia, Myelomonocytic, Acute; Colonic Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphomatoid Granulomatosis; Wilms Tumor; Leukemia, Myelomonocytic, Chronic; Lymphoma, Large-Cell, Immunoblastic; Salivary Gland Neop Details
Quizartinib AC-220; ASP-2689; AC-010220 Approved Ambit Biosciences Co Vanflyta Japan Leukemia, Myeloid, Acute Daiichi Sankyo Co Ltd 2019-06-18 Solid tumours; Leukemia; Myelodysplastic Syndromes; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Chronic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef United States Idiopathic Pulmonary Fibrosis Boehringer Ingelheim Gmbh 2014-10-15 Gliosarcoma; Breast Neoplasms; Sarcoma; systemic sclerosis-associated interstitial lung disease; Adenocarcinoma, Clear Cell; Peritoneal Neoplasms; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Genital Neoplasms, Female; Silicosis; Prostatic Neoplasms; Carcinoma, Squamous Cell; Appendiceal Neoplasms; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Uterine Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Colonic Neoplasms; Ovarian Neoplasms; Telangiectasia, Hereditary Hemorrhagic; Esophageal Neoplasms; Rejection of lung transplantation; Carcinoid Tumor; Endometrial Stromal Tumors; Carcinoma, Renal Cell; Radiation Pneumonitis; Neoplasms; Idiopathic Pulmonary Fibrosis; Solid tumours; Scleroderma, Systemic; Glioblastoma; Small Cell Lung Carcinoma; Mesothelioma; Neuroendocrine Tumors; Pulmonary Fibrosis; Lung Diseases, Interstitial; Multiple Myeloma; Asbestosis; Oligodendroglioma Details
pacritinib citrate SB-1518; ONX-0803 Approved S*BIO Pte Ltd, Concert VONJO United States Primary Myelofibrosis Cti Biopharma Corp 2022-02-28 Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Thrombocythemia, Essential; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, T-Cell; Lymphoma, Non-Hodgkin; Lymphoma; Waldenstrom Macroglobulinemia; Lymphoma, T-Cell, Cutaneous; Leukemia, Myelomonocytic, Juvenile; Thrombocytopenia; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Hepatic Insufficiency; Lymphoproliferative Disorders; Lymphoma, T-Cell, Peripheral; Primary Myelofibrosis; Lymphoma, Mantle-Cell; Coronavirus Infections; Leukemia, Myelomonocytic, Chronic; Hodgkin Disease; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myeloproliferative Disorders; Myelodysplastic Syndromes; Polycythemia Vera; Lymphoma, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia Details
Brigatinib AP-26113 Approved Ariad, Takeda Pharmaceutical Co Ltd Alunbrig United States Carcinoma, Non-Small-Cell Lung Takeda Pharmaceuticals U.S.A. Inc 2017-04-28 Ependymoma; Solid tumours; Carcinoma; Neoplasms; Neurofibromatosis 2; Myofibroma; Lung Neoplasms; Lymphoma, Large-Cell, Anaplastic; Brain metastases; Granuloma, Plasma Cell; Carcinoma, Non-Small-Cell Lung; Meningioma; Neurilemmoma; Neuroma, Acoustic; Sarcoma, Kaposi Details
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx United States Thyroid Neoplasms; Carcinoma, Neuroendocrine Exelixis Inc 2012-11-29 Sarcoma, Ewing; Thyroid Neoplasms; Thymus Neoplasms; Gliosarcoma; Colorectal Neoplasms; Peritoneal Neoplasms; Bile Duct Neoplasms; Hepatic Insufficiency; Astrocytoma; Breast Neoplasms; Lymphoma; Osteosarcoma; Carcinoma, Adenosquamous; Adenocarcinoma, Clear Cell; Sarcoma, Clear Cell; Medullary thyroid cancer (MTC); Cholangiocarcinoma; Prostatic Neoplasms; Neurofibroma, Plexiform; Urethral Neoplasms; Carcinoma, Neuroendocrine; Meningioma; Carcinoma, Non-Small-Cell Lung; Paraganglioma; Melanoma; Carcinoma, Endometrioid; Thyroid Cancer, Papillary; Adenocarcinoma; Neoplasms, Germ Cell and Embryonal; Carcinoma, Hepatocellular; Neuroblastoma; Glioma; Leukemia, Myeloid, Acute; Carcinoma, Squamous Cell; Endometrial Neoplasms; Lung Neoplasms; Sarcoma, Alveolar Soft Part; Uterine Neoplasms; Fallopian Tube Neoplasms; Carcinoid Tumor; Neurofibromatoses; Seminoma; Carcinoma, Transitional Cell; Glioblastoma; Rejection of liver transplantation; Carcinoma, Merkel Cell; Hepatoblastoma; Pain; Pheochromocytoma; Neoplasms; Carcin Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; PNU-290940AD; PHA-290940AD; GB-102; PNU-290940; SU-011248-L-malate salt Approved Pfizer Pharmaceuticals Ltd (China) 索坦, Sutent United States Carcinoma, Renal Cell; Gastrointestinal Stromal Tumors Cppi Cv 2006-01-26 Teratoma; Ovarian Neoplasms; Fibromatosis, Aggressive; Solid tumours; Intestinal Neoplasms; Kidney Neoplasms; Liver Neoplasms; Leiomyosarcoma; Fibrosarcoma; HIV Infections; Head and Neck Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Leukemia, Myeloid, Accelerated Phase; Leukemia; Leukemia, Myelogenous, Chronic; Lymphoma, T-Cell, Peripheral; Ependymoma; Carcinoma, Renal Cell; Histiocytoma, Malignant Fibrous; Carcinoma; Hemangioblastoma; Carcinoma, Islet Cell; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thoracic Neoplasms; Leukemia, Hairy Cell; Abdominal Neoplasms; Esophageal Neoplasms; Polycythemia Vera; Pelvic Neoplasms; Pheochromocytoma; Glioblastoma; Neurofibromatoses; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Neoplasms; Immunoglobulin Ligh Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
MAX-40279 MAX-40279-001; Max-40279; MAX-40279-01; MAX-4 Phase 2 Clinical Leukemia; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Myelodysplastic Syndromes; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Neoplasm Metastasis Details
SKI-G-801 G-801; SKI-G-801; G-749 Hydrochloride Phase 1 Clinical Oscotec Inc Leukemia, Myeloid, Acute Details
HEC-73543 HEC-73543 Phase 3 Clinical Hec Pharm Co Ltd Leukemia, Myeloid, Acute Details
QBH-196 QBH-196 Phase 1 Clinical Shenyang Pharmaceutical University Solid tumours; Stomach Neoplasms Details
FN-1501 FN-1501; LT-171-861 Phase 2 Clinical China Pharmaceutical University Solid tumours; Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Hepatocellular Details
Crenolanib Besylate CP-868596-26; IND-112201; CP-868596; ARO-002; ARO-002-26 Phase 3 Clinical Pfizer Pharmaceuticals Ltd (China) Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Glioma Details
Tuspetinib HM-43239 Phase 2 Clinical Hanmi Pharmaceutical Co Ltd Leukemia, Myeloid, Acute Details
RIVAL-01 TBio-6517; TAK-605 Phase 2 Clinical Takeda Pharmaceutical Co Ltd, Turnstone Biologics Inc Solid tumours; Carcinoma, Renal Cell; Mesothelioma; Colorectal Neoplasms; Oropharyngeal Neoplasms; Carcinoma, Squamous Cell; Melanoma; Uterine Cervical Neoplasms Details
ETH-155008 ETH-155008 Phase 1 Clinical Yunnan Shengke Pharmaceutical Co Ltd Leukemia; Lymphoma, B-Cell; Leukemia, Promyelocytic, Acute; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin Details
Emirodatamab AMG-427 Phase 1 Clinical Amgen Inc Leukemia, Myeloid, Acute Details
Anti-FLT3 CAR-T Cell Therapy (PersonGen Biomedicine) TAA05 Phase 2 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Leukemia, Myeloid, Acute Details
XY0206 XY-0206 Phase 1 Clinical Shijiazhuang Yiling Pharmaceutical Co Ltd, Nanjing University Of Chinese Medicine Solid tumours; Leukemia, Myeloid, Acute Details
Ningetinib Tosylate CT-053-PTSA; CT-053 Phase 2 Clinical Hec Pharm Co Ltd Solid tumours; Intestinal Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Lung Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
LNK-01002 LNK01002 Phase 1 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Hematologic Neoplasms; Myeloproliferative Disorders; Primary Myelofibrosis; Leukemia, Myeloid, Acute Details
SEL-24 SEL-24 program; SEL-24; MEN-1703; SEL-24-1; SEL-24-B489 Phase 2 Clinical Selvita Leukemia, Myeloid, Acute Details
CLN-049 CLN-049 Phase 1 Clinical University Of Tubingen, German Cancer Research Center (Dkfz) Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
SKLB-1028 SKLB-1028 Phase 3 Clinical Sichuan University, CSPC Pharmaceutical Group Ltd Solid tumours; Leukemia, Promyelocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute Details
AMG-553 AMG-553 Phase 1 Clinical Amgen Inc Leukemia, Myeloid, Acute Details
Flonoltinib maleate Phase 1 Clinical Chengdu Zenitar Biomedical Technology Co Ltd Myeloproliferative Disorders; Primary Myelofibrosis Details
Luxeptinib CG-806; CG-026806 Phase 1 Clinical Crystalgenomics Inc, Aptose Myelodysplastic Syndromes; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Leukemia, Lymphocytic, Chronic, B-Cell Details
Sorafenib Tosylate/MG-K10 MG-D-1609 Phase 2 Clinical Metagone Biotech Inc Solid tumours Details
HYML-122 HYML-122; CHMFL-FLT3-122 Phase 2 Clinical Hefei Academy Of Physical Sciences, Chinese Academy Of Sciences, Hefei Cosource Pharmaceuticals Leukemia, Myeloid, Acute Details
HH-30134 HH-30134 Phase 1 Clinical ShangHai HaiHe Biopharma Co Ltd Solid tumours; Neoplasms Details
FF-10101 FF-10101; FF-10101-01; FF-10101 succinate Phase 2 Clinical Fujifilm Corp Leukemia, Myeloid, Acute Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Srl Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
MRX-2843 MRX-2843; UNC-2025; UNC-2371 Phase 2 Clinical Meryx Inc, University Of North Carolina At Chapel Hill, University Of Colorado At Denver Leukemia; Solid tumours; Neoplasms; Pathologic Processes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Lung Neoplasms; Neoplastic Processes; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Lestaurtinib SPM-924; A-154475.0; KT-5555; SP-924; CEP-701 Phase 3 Clinical Kyowa Hakko Kirin Co Ltd Leukemia; Leukemia, Myeloid; Bone Marrow Neoplasms; Polycythemia Vera; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Psoriasis; Primary Myelofibrosis; Leukemia, Myeloid, Acute; Thrombocythemia, Essential Details
Famitinib Malate SHR-1020 Phase 3 Clinical Jiangsu Hengrui Medicine Co Ltd Cholangiocarcinoma; Neoplasm Metastasis; Gastrointestinal Neoplasms; Adenocarcinoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Endometrial Neoplasms; Lung Neoplasms; Urologic Neoplasms; Genital Neoplasms, Female; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Ovarian Neoplasms; Nasopharyngeal Carcinoma; Breast Neoplasms; Carcinoma, Transitional Cell; Pancreatic neuroendocrine tumors (pNET); Nasopharyngeal Neoplasms; Idiopathic Pulmonary Fibrosis; Triple Negative Breast Neoplasms; Neoplasms; Carcinoma, Renal Cell; Solid tumours; Biliary Tract Neoplasms Details
E-6201 E-6201 Phase 1 Clinical Eisai Co Ltd Solid tumours; Neoplasms; Leukemia, Myelomonocytic, Chronic; Myeloproliferative Disorders; Psoriasis; Brain metastases; Leukemia, Myeloid, Acute; Melanoma Details
TT-00973 TT-00973 Phase 1 Clinical TransThera Sciences (Nanjing) Inc Solid tumours Details
Emavusertib CA-4948; AU-4948 Phase 2 Clinical Aurigene Hematologic Neoplasms; Anemia; Stomach Neoplasms; Esophageal Neoplasms; Myelodysplastic Syndromes; Pancreatic Neoplasms; Carcinoma, Pancreatic Ductal; Leukemia, Myeloid, Acute; Melanoma Details
KC1036 KC1036; KC-1036 Phase 2 Clinical Beijing Konruns Pharmaceutical Co Ltd Solid tumours; Hematologic Neoplasms; Neoplasms; Digestive System Neoplasms; Thymus Neoplasms; Adenocarcinoma; Neoplasm Metastasis Details
EP-0042 EP-0042 Phase 2 Clinical Ellipses Pharma Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Clifutinib Besylate Phase 3 Clinical Guangdong Dongyangguang Pharmaceutical Co Ltd Leukemia, Myeloid, Acute Details
LM-061 LM-061 Phase 2 Clinical Shanghai Lixin Pharmaceutical Research and Development Co Ltd Solid tumours Details
Glesatinib MGCD-265; MG-90265X; 7Q29OXD98N; MG-90265H9; MG-90265gly; MG-90265 Phase 2 Clinical Mirati Therapeutics Inc Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Fms-like tyrosine kinase 3 ligand (Celldex Therapeutics) CDX-301 Phase 2 Clinical Amgen Inc Skin Melanoma; Leukemia, Myelogenous, Chronic; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Myelodysplastic Syndromes; Hodgkin Disease; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung; Melanoma; Leukemia, Lymphocytic, Chronic, B-Cell Details
Merestinib LY-2801653; 5OGS5K699E Phase 2 Clinical Eli Lilly And Company Solid tumours; Biliary Tract Neoplasms; Skin Melanoma; Bone metastases; Neoplasms; Pancreatic Neoplasms; Microsatellite instability-high cancer; Lymphoma, Mantle-Cell; Cholangiocarcinoma; Breast Neoplasms; Colorectal Neoplasms; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Gallbladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Mivavotinib TAK-659; CB-659 Phase 2 Clinical Takeda Pharmaceutical Co Ltd Lymphoma, B-Cell; Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Lymphoma, Follicular; Plasmablastic Lymphoma; Lymphoma, Non-Hodgkin; Lymphoma; Leukemia, Myeloid, Acute; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details
Flysyn 4G8-SDIEM Phase 2 Clinical Synimmune Gmbh Leukemia, Myeloid, Acute Details
Zotiraciclib TG-02; SB-1317 Phase 2 Clinical Syncore Biotechnology Co Ltd Glioblastoma; Neoplasms; Brain Neoplasms; Astrocytoma; Gliosarcoma; Glioma; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell Details

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