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Flt-3

Flt-3 Molecule Information

Name:Tyrosine-protein kinase receptor FLT3
Target Synonym:EC 2.7.10?EC:2.7.10.1?Receptor-type tyrosine-protein kinase FLT3?FLT3?FLT-3?FLK2?STK-1?FL cytokine receptor?Fms Related Tyrosine Kinase 3?Stem Cell Tyrosine Kinase 1?CD135 Antigen?CD135?STK1?Growth Factor Receptor Tyrosine Kinase Type III?Fms-Related Tyro
Number of Launched Drugs:10
Number of Drugs in Clinical Trials:30
Lastest Research Phase:Approved

Flt-3 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
FL3-M52H6 Mouse Mouse Flt-3 / Flk-2 Protein, His Tag
FL3-M52H6-structure
FL3-M52H6-sds
FL3-H5258 Human Human Flt-3 / Flk-2 Protein, Fc Tag
FL3-H5258-structure
FL3-H5258-sds
FL3-H5258-elisa_1

Flt-3 Part of Bioactivity data

FL3-H5258-ELISA
Human Flt-3, Fc TagHuman Flt-3, Fc Tag (Cat. No. FL3-H5258) ELISA bioactivity

Immobilized Human Flt-3 Ligand, Tag Free (Cat. No. FLL-H5218) at 1 μg/mL (100 μL/well) can bind Human Flt-3, Fc Tag (Cat. No. FL3-H5258) with a linear range of 2-31 ng/mL (QC tested).

Flt-3 Molecule Synonym Name

Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3

Flt-3 Molecule Background

Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Flt-3 References

Flt-3 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath s:18:"Daiichi Sankyo Inc"; 2019-08-02 Giant Cell Tumor of Tendon Sheath; Solid tumours; Synovitis, Pigmented Villonodular; Hodgkin Disease; Arthritis, Rheumatoid; Glioblastoma; Giant Cell Tumors; Prostatic Neoplasms; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef Mainland China Idiopathic Pulmonary Fibrosis s:39:"Boehringer Ingelheim International Gmbh"; 2014-10-15 Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Scleroderma, Systemic; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Multiple Myeloma; Prostatic Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Hepatic Insufficiency; Genital Neoplasms, Female; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Fedratinib TG-101348; SAR-302503 Approved Sanofi Inrebic United States Primary Myelofibrosis s:34:"Impact Pharmaceutical Services Inc"; 2019-08-16 Hematologic Neoplasms; Solid tumours; Polycythemia Vera; Kidney Diseases; Hepatic Insufficiency; Primary Myelofibrosis; Thrombocythemia, Essential Details
Ponatinib Hydrochloride AP-24534; INCB-84344; AP24534 HCl; AP24534-HCL; AP24534 hydrochloride Approved Ariad Iclusig Japan Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic, BCR-ABL Positive s:22:"Otsuka Holdings Co Ltd"; 2012-12-14 Leukemia; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Solid tumours; Hematologic Neoplasms; Blast Crisis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Chronic-Phase; Philadelphia Chromosome; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Lymphoma; Leukemia, Biphenotypic, Acute Details
Quizartinib AC-220; ASP-2689; AC-010220 Approved Ambit Biosciences Vanflyta Japan Leukemia, Myeloid, Acute s:4:"null"; 2019-06-18 Leukemia; Solid tumours; Myelodysplastic Syndromes; Myeloproliferative Disorders; Hepatic Insufficiency; Leukemia, Myeloid, Acute Details
Gilteritinib fumarate ASP-2215 hemifumarate; ASP-2215; 66D-92MGC8M (UNII code) Approved Astellas Pharma Inc Xospata EU Leukemia, Myeloid, Acute s:25:"Astellas Pharma Europe Bv"; 2018-09-21 Solid tumours; Renal Insufficiency; Hepatic Insufficiency; Leukemia, Myeloid, Acute Details
Midostaurin PKC-412; PKC-412A; CGP-41231; CGP-41251 Approved Novartis Pharma Ag Rydapt EU Leukemia, Myeloid, Acute; Mastocytosis s:22:"Novartis Europharm Ltd"; 2017-04-28 Hematologic Neoplasms; Leukemia; Mastocytosis, Systemic; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc 多吉美, Nexavar United States Thyroid Neoplasms s:14:"Bayer Hlthcare"; 2005-12-01 Liver Diseases; Melanoma; Neoplasm Metastasis; Fasting; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Lung Neoplasms; Thyroid Neoplasms; Hepatitis C; Breast Neoplasms; Hepatitis B; Liver Neoplasms; Neoplasms; Kidney Diseases; Pancreatic Neoplasms; Carcinoma; Carcinoma, Renal Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Ovarian Neoplasms; Kidney Neoplasms; Solid tumours Details
Sunitinib Malate SU-11248; SU-010398; PHA-290940; PNU-290940; PHA-290940AD; PNU-290940AD; SU-011248-L-malate salt; GB-102 Approved Pfizer Pharmaceuticals Ltd (China) 索坦, Sutent Japan Pancreatic neuroendocrine tumors (pNET) s:10:"Pfizer Inc"; 2006-01-26 Prostatic Neoplasms; Retinal Vein Occlusion; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Urogenital Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Breast Neoplasms; Diabetic macular oedema; Kidney Neoplasms; Urologic Diseases; Neuroendocrine Tumors; Kidney Diseases; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Stomach Neoplasms; Carcinoma, Islet Cell; Carcinoma, Renal Cell; Solid tumours; Liver Neoplasms Details
Brigatinib AP-26113 Approved Takeda Pharmaceutical Co Ltd, Ariad Alunbrig Japan Carcinoma, Non-Small-Cell Lung s:6:"Takeda"; 2017-04-28 Solid tumours; Carcinoma; Lung Neoplasms; Lymphoma, Large-Cell, Anaplastic; Carcinoma, Non-Small-Cell Lung Details

Flt-3 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CG-806 CG-806; CG-026806 Phase 2 Clinical Crystalgenomics Inc, Aptose Hematologic Neoplasms; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Leukemia, Lymphocytic, Chronic, B-Cell Details
FN-1501 FN-1501 Phase 1 Clinical China Pharmaceutical University Neoplasms; Leukemia, Myeloid, Acute Details
QBH-196 QBH-196 Phase 1 Clinical Shenyang Pharmaceutical University Stomach Neoplasms Details
SKI-G-801 G-801; SKI-G-801; G-749 Hydrochloride Phase 1 Clinical Oscotec Leukemia, Myeloid, Acute Details
FF-10101 FF-10101; FF-10101-01; FF-10101 succinate Phase 2 Clinical Fujifilm Corp Leukemia, Myeloid, Acute Details
Mivavotinib TAK-659 Phase 2 Clinical Takeda Pharmaceutical Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Lymphoma, Large B-Cell, Diffuse; Triple Negative Breast Neoplasms; Lymphoma, Follicular; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Ningetinib Tosylate CT-053; CT-053-PTSA Phase 2 Clinical Hec Pharm Co Ltd Intestinal Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Leukemia, Myeloid, Acute; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Clifutinib Besylate Phase 1 Clinical Guangdong Dongyangguang Pharmaceutical Co Ltd Leukemia, Myeloid, Acute Details
Flysyn 4G8-SDIEM Phase 2 Clinical Synimmune Leukemia, Myeloid, Acute Details
Lestaurtinib SP-924; CEP-701; KT-5555; SPM-924; A-154475.0 Phase 3 Clinical Kyowa Hakko Kirin Bone Marrow Neoplasms; Leukemia, Myeloid; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Psoriasis; Leukemia, Myeloid, Acute; Thrombocythemia, Essential Details
XY0206 XY-0206 Phase 1 Clinical Shijiazhuang Yiling Pharmaceutical Co Ltd, Nanjing University Of Chinese Medicine Solid tumours; Leukemia, Myeloid, Acute Details
Fms-like tyrosine kinase 3 ligand (Celldex Therapeutics) CDX-301 Phase 2 Clinical Amgen Inc Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Hodgkin Disease; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell Details
E-6201 E-6201 Phase 2 Clinical Eisai Co Ltd Leukemia, Myelomonocytic, Chronic; Myeloproliferative Disorders; Myelodysplastic Syndromes; Psoriasis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Brain metastases; Melanoma Details
SEL-24 SEL-24; MEN-1703; SEL-24-1; SEL-24-B489; SEL-24 program Phase 2 Clinical Selvita Leukemia, Myeloid, Acute Details
MAX-40279 Max-40279; MAX-40279-01; MAX-4; MAX-40279-001 Phase 1 Clinical Guangzhou Maxinovel Pharmaceiticals Co Ltd Leukemia, Myeloid, Acute Details
RIVAL-01 TBio-6517 Phase 2 Clinical Turnstone Biologics Triple Negative Breast Neoplasms; Colorectal Neoplasms Details
Sorafenib/MG-005 MGD-1509 Phase 2 Clinical Metagone Biotech, Tri-Service General Hospital Neoplasms Details
Hydroxychloroquine/Sorafenib Phase 1 Clinical Vg Life Sciences Ovarian Neoplasms Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
MRX-2843 MRX-2843; UNC-2025; UNC-2371 Phase 1 Clinical Meryx, University Of North Carolina At Chapel Hill, University Of Colorado At Denver Solid tumours; Pathologic Processes; Neoplastic Processes; Neoplasm Metastasis Details
PLX-7486 PLX-7486; PLX7486-TsOH Phase 1 Clinical Daiichi Sankyo Co Ltd Giant Cell Tumor of Tendon Sheath; Solid tumours; Pancreatic Neoplasms Details
HM-43239 Phase 2 Clinical Hanmi Pharmaceutical Co Ltd Leukemia, Myeloid, Acute Details
Dovitinib TKI-258; CHIR-258; GFKI-258; CHIR-258LC; NVP-TKI258 Phase 2 Clinical Novartis Pharma Ag Carcinoma, Adenoid Cystic; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Thyroid Neoplasms; Leukemia, Myeloid, Acute; Endometrial Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hepatic Insufficiency; Prostatic Neoplasms; Breast Neoplasms; Solid tumours; Adrenocortical Carcinoma; Multiple Myeloma; Pancreatic Neoplasms; Glioblastoma; Adenocarcinoma, Scirrhous; Carcinoma; Carcinoma, Renal Cell; Stomach Neoplasms; Liver Neoplasms; Linitis Plastica; Stomach Diseases Details
SKLB-1028 SKLB-1028 Phase 3 Clinical Sichuan University, CSPC Pharmaceutical Group Ltd Leukemia, Myeloid, Acute Details
CA-4948 AU-4948; CA-4948 Phase 1 Clinical Aurigene Hematologic Neoplasms; Leukemia, Myeloid; Myelodysplastic Syndromes; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute Details
Crenolanib Besylate ARO-002; CP-868596; ARO-002-26; IND-112201; CP-868596-26 Phase 3 Clinical Pfizer Pharmaceuticals Ltd (China) Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Glioblastoma; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Glioma; Carcinoma, Non-Small-Cell Lung Details
AMG-427 (Amgen) AMG-427 Amgen Inc Details
AMG-553 AMG-553 Phase 1 Clinical Amgen Inc Leukemia, Myeloid, Acute Details
Pacritinib SB-1518; ONX-0803 Phase 3 Clinical Syncore Biotechnology Co Ltd, Concert Lymphoma, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Polycythemia Vera; Hodgkin Disease; Myelodysplastic Syndromes; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Chronic; Coronavirus Disease 2019 (COVID-19); Lymphoma, Mantle-Cell; Coronavirus Infections; Primary Myelofibrosis; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Lymphoma; Thrombocythemia, Essential Details
Zotiraciclib SB-1317; TG-02 Phase 1 Clinical Syncore Biotechnology Co Ltd Myeloproliferative Disorders; Blast Crisis; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Glioma; Leukemia, Myeloid, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Hepatocellular Details
HYML-122 HYML-122; CHMFL-FLT3-122 Phase 1 Clinical Hefei Academy Of Physical Sciences, Chinese Academy Of Sciences, Hefei Heyuan Pharmaceutical Co Ltd Leukemia, Myeloid, Acute Details

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