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Home PageAll MoleculesCD46
CD46
CD46 Overview
| English Name | Membrane cofactor protein | Approved Drugs | 0 |
| Drugs in Clinical Trials | 5 | Target Synonym | TLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544 |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | Membrane cofactor protein |
| Target Synonym | TLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 5 |
| Highest Development Stage | Phase 2 Clinical |
CD46 Product List
- Product Category
Protein (5)
- Product Status
Launched (5)
- Species
Human (5)
- Tag
His Tag (4)Fc Tag (1)
- Conjugate
Unconjugated (2)FITC Labeled (1)APC Labeled (1)PE Labeled (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
CD6-H5226 |  Human | HEK293 | Human CD46 Protein, His Tag, low endotoxin (MALS verified) |  |  |  |  Add to Cart |
CD6-H5254 | Human | HEK293 | Human CD46 Protein, Fc Tag (MALS verified) |  | | | Add to Cart |
CD6-HA224 | Human | HEK293 | APC-Labeled Human CD46 Protein, His Tag |  | Add to Cart | ||
CD6-HF223 | Human | HEK293 | FITC-Labeled Human CD46 Protein, His Tag |  | | Add to Cart | |
CD6-HP223 | Human | HEK293 | PE-Labeled Human CD46 Protein, His Tag |  | Add to Cart |
Total: 5
- 1
CD46 Background
Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).
CD46 Synonyms
CD46,AHUS2,MCP,MIC10,TLX,TRA2.10
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Anti-CD46 antibody drug conjugate (Fortis Therapeutics) | FG-3246; FOR-46 | Phase 2 Clinical | University Of California San Diego | Multiple Myeloma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant | Details |
| Enadenotucirev | ColoAd-1; Oncolytic Ad11/Ad3 | Phase 1 Clinical | Akamis Bio Ltd | Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Colorectal Neoplasms; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms | Details |
| AugmAb | BRM-132 | Phase 1 Clinical | Compliment Corp | Lymphoma, Non-Hodgkin; Neoplasms | Details |
| YS-5 | YS-5 | Phase 1 Clinical | Fortis Therapeutics Inc, United States Department Of Defense | Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant | Details |
| FG-3180 | 89Zr-DFO-YS-5; 89Zr-DFO-YS5 | Phase 1 Clinical | Fortis Therapeutics Inc | Multiple Myeloma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant | Details |
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