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CD46 Molecule Information

Name:Membrane cofactor protein
Target Synonym:MCP;TLX;Trophoblast leukocyte common antigen;MIC10;CD46
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
CD6-H5226 Human Human CD46 Protein, His Tag

CD46 Molecule Synonym Name


CD46 Molecule Background

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

CD46 References

CD46 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Enadenotucirev ColoAd-1; Oncolytic Ad11/Ad3 Phase Ⅱ PsiOxus Therapeutics, Merck Sharp & Dohme Urogenital cancer, Non small cell lung cancer (NSCLC), Colorectal cancer, Bladder cancer, Ovarian cancer, Renal carcinoma Details
Carcinoembryonic antigen-expressing measles virus (National Cancer Institute) Phase Ⅰ National Cancer Institute Glioma, Glioblastoma, Primary Peritoneal Cavity Cancer, Ovarian cancer, Anaplastic astrocytoma Details
AugmAb BRM-132 Phase Ⅰ BRIM Biotechnology, PAI Life Sciences Cancer Details
FOR-46 FOR-46,FOR 46,FOR46 Phase Ⅰ University of California San Diego Prostate cancer, Multiple myeloma (MM) Details

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