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CD46

Brief Information

Name:Membrane cofactor protein
Target Synonym:TLX,MCP,CD46,CD46 Molecule,Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen),Antigen Identified By Monoclonal Antibody TRA-2-10,CD46 Molecule, Complement Regulatory Protein,CD46 Antigen, Complement Regulatory Protein,Trophobl
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CD6-H5226 Human Human CD46 Protein, His Tag
CD6-H5226-structure
CD6-H5226-sds

Synonym Name

CD46,AHUS2,MCP,MIC10,TLX,TRA2.10

Background

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
FOR-46 FOR-46 Phase 1 Clinical University Of California San Diego Multiple Myeloma; Prostatic Neoplasms Details
Enadenotucirev ColoAd-1; Oncolytic Ad11/Ad3 Phase 2 Clinical Psioxus Therapeutics Ovarian Neoplasms; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Neoplasms, Glandular and Epithelial; Colonic Neoplasms; Urinary Bladder Neoplasms; Colorectal Neoplasms; Urogenital Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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