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GAS6 Molecule Information

Name:Growth arrest-specific protein 6
Target Synonym:GAS6,AXLLG,Growth Arrest Specific 6,AXL Receptor Tyrosine Kinase Ligand,AXL Stimulatory Factor,Growth Arrest-Specific Protein 6,GAS-6,AXSF,FLJ34709,DKFZp666G247
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

GAS6 Molecule Synonym Name


GAS6 Molecule Background

GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG. Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

GAS6 References

GAS6 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AVB-S6-500 Aravive S-6; AVB-S6-500; Ruga-S6; 3D-229; 3D229; AVB-500 Phase 3 Clinical Aravive Biologics Ovarian Neoplasms; Glomerulonephritis, IGA; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Fallopian Tube Neoplasms Details

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