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Your Position: Home > Extracellular Matrices > Mogengel > AC-M082777

Mogengel Matrix IPSC Level (Acro Certified)

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  • Key Benefits

    1. ES Cell Culture Validated - Strict Quality Control Assays for every produced lot.
    2. Lot-to-lot Consistency - Strict manufacturing controls and management systems.
    3. Stable, Long-term Supply - Large-scale manufacturing capacity and ACRO’s global supply chain.
    4. Cost Effective - Bulk pricing available to meet your research needs.

  • Intended Use
    Mogengel Matrix IPSC Level is intended to be used as a supplement to specified media to culture stem cells including human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSCs). Mogengel Matrix IPSC Level provides the reproducibility and consistency required for trophoblast culture of hESCs and iPSCs and can be used for in vivo differentiation studies such as teratoma formations.
  • Product Description
    1. Basement membranes are comprised of continuous sheets of a specialized extracellular matrix. It acts an interface between various types of cells, including muscle, neuronal, epithelial, or endothelial cells, along with adjacent stroma. Basement membranes are an essential part in the organization of tissues forming the scaffolding and support for cellular growth and cell layers. They also affect a variety of cellular mechanisms such as adhesion, migration, proliferation, and differentiation. Basement membranes are selectively degraded and regenerated during development and wound healing, forming the base scaffold for tissue reconstruction. Basement membranes also act as a major barrier to invasion by metastatic tumor cells.
    2. Mogengel Matrix IPSC Level is a soluble form of basement membrane that is purified from gene-edited mouse tumor cells grown in LDEV-free mouse populations. Reconstitution into the original basement membrane form occurs at 37℃ and is mainly comprised of laminin, collagen IV, entactin, and heparin sulfate proteoglycan.
Bioactivity-Stem Cell Culture

Mogengel (Cat. No. AC-M082777) 1:100 dilution coating the plates,supports stable passage of EPSCs (extended pluripotent stem cells) from P1 to P4.

Protein ConcentrationWithin 8 to 13 mg/mL, tested by BCA assay.
Endotoxin Level< 4.5 EU/mL, tested by LAL assay.
ES Cell CultureES cells can grow well under the plate coated with Mogengel Matrix.
*Evaluated Mogengel Matrix: Medium Ratio = 1:100 (v/v).
Organoid CultureMouse intestinal organoids, mouse liver ductal organoids and mouse airway organoids could grow well under the Mogengel Matrix.
*Evaluated Mogengel Matrix: Medium Ratio = 7:3 (v/v).
AngiogenesisBlood vessel formation is observed, tested by HUVEC angiogenesis assay.
*Evaluated Mogengel Matrix: Medium Ratio = 1:0 (original formulation), 2:1, 1:1 (v/v).
SterilityNo growth observed after 14 days. Testing for the detection of bacteria, fungi, and mycoplasma through cell culture.
Viral TestingTested negative by ELISA, bacterial culture and microscope observation for a total of 19 bacterial and virus strains, and additional murine infectious agents including LDEV.
StabilityProduct is stable for at least two years from date of manufacture when stored at ≤ -20℃. See lot specific Certificate of Analysis for expiration date.
Shipping ConditionsThe product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
StorageStore at -20℃. Avoid multiple freeze-thaws. Do not store in frost-free freezer. KEEP FROZEN.
Acro Certify Disclaimer
This product is one of ACROBiosystems' Certify products. ACROBiosystems and our Certify partners have established a close partnership that includes an in-depth review of quality management and quality audits this product. Products from our Certify partners have been qualified by ACROBiosystems to be included under Acro Certify. ACROBiosystems may provide Product information, including technical information, specifications, recommendations, literature, and other material (collectively, "Product Information") for customer's convenience. The accuracy and completeness of Product Information is not guaranteed and is subject to change without notice. ACROBiosystems is not responsible for the intellectual property or impact to intellectual property for products sold under Acro Certify.

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