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Your Position: Home > Protein > Nuclease > NUE-S5117

Salt Active GENIUS™Nuclease, premium grade

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  • Features

    Salt Active GENIUS™Nuclease, premium grade is designed for preclinical stage, has more comprehensive QC testing (such as HCP and so on) and tighter specifications based on the following GENIUS features.
    Salt Active GENIUS™Nuclease, premium grade has the same activity and performance with GMP Grade Salt Active Nuclease, which enables a seamless transition from preclinical development to clinical phases. By using Salt Active GENIUS™Nuclease, premium grade in your development phase you can easily transit into clinical and commercial phases and avoid needing to amend your manufacturing process and undertake comparability studies.

  • Product Details
    Salt Active GENIUS™Nuclease is developed with ACRObiosystems' unique enzyme AI evolution platform based on wild-type Serratia marcescens endonuclease. It is capable of maintaining high specific activity to effectively degrade nuclei acids in any form across a broad salt concentration range (0-500mM NaCl), especially high salt up to 500mM NaCl, which makes it suitable for nucleic acid removal in processes that of higher salt conditions. The enzyme is a non-specific nuclease with high specific activity, degrading single- and double-stranded nucleic acids in any form (single stranded, double stranded, linear, circular, and supercoiled). It hydrolyzes internal phosphodiester bonds present between the nucleotides to 5’- phosphorylated oligonucleotides of 3-5 bases in length.
  • Application

    Elimination of nucleic acids from biologics, suitable for samples with 0-500 mM salt in presence of 5-10 mM Mg++
    • viral vaccine development process
    • viral vector development process for cell and gene therapy (CGT)
    • Other biologics development processes

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-HPLC.

  • Enzyme Activity
    ≥250 U/μL
  • Host Cell Protein
    <0.05 ng/µg of protein tested by ELISA.
  • Sterility
  • Mycoplasma
  • Endotoxin
    Less than 0.01 EU per μg by the LAL method.
  • Formulation

    Supplied as 0.2 μm filtered solution in 25 mM Tris, 500 mM NaCl, 5 mM MgCl2, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    This product is stable after storage at:

    1. The product MUST be stored at -20°C or lower upon receipt;
    2. -20°C for 24 months under sterile conditions.
Nuclease SDS-PAGE

The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

Nuclease SEC-HPLC

The purity of Salt Active GENIUSNuclease, premium grade (Cat. No. NUE-S5117) was greater than 95% as determined by SEC-HPLC.


Specific activity for Salt Active GENIUS™Nuclease, premium grade is measured under standard assay conditions. The specific activity of Salt Active GENIUS™Nuclease, premium grade is >4.3E+05 unit/mg at 500 mM salt concentration. One unit will digest sonicated salmon sperm DNA to acid-soluble oligonucleotides equivalent to a ΔA260 of 1.0 in 30 min at pH 8.0 at 37 °C, which corresponds approximately to complete digestion of 37 μg DNA (QC tested).

 Nuclease ENZYME

Specific activity of Salt Active GENIUS™Nuclease, premium grade at different salt concentrations.

  • Clinical and Translational Updates

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ETA of in-stock products: 2 business days

Price(USD) : $160.00

Price(USD) : $640.00

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