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Your Position: Home > Protein > IRAK4 > IR4-C5545

Canine IRAK4 Protein, His Tag

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  • Synonym
    IMD67, IPD1, IRAK-4, NY-REN-64, REN64
  • Source
    Canine IRAK4 Protein, His Tag(IR4-C5545) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ser 460 (Accession # A0A8I3S726-1).
    Predicted N-terminus: Met 1
  • Molecular Characterization
    IRAK4 Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 53.4 kDa. The protein migrates as 55-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5, 1 mM DTT with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
SDS-PAGE
IRAK4 SDS-PAGE

Canine IRAK4 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • Background
    This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Clinical and Translational Updates

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