>Leukocyte Surface Antigen CD47
CD47,or Integrin-associated protein (IAP), is first discovered in a study aimed at studying integrin αvβ3. It turned out to be associated in cis with integrin αvβ3 on the cell membrane. Followup studies has established CD47 as the quintessential "marker of self" expressed in all cell types. It's a key regulator of tissue homeostasis, and is also involved in a variety of diseases ranging from atherosclerosis to cancer. CD47 protects the host cells by suppressing phagocytosis. It's well established that cancer cell-expressed CD47 interacts with the NK cell-expressed SIRP family proteins, SIRP alpha and SIRP gamma. By so doing, it protects the cancer cell from being eliminated by the innate immune response.
In addition, CD47 is also essential for TSP-1 mediated vascular NO signaling. It regulates CD36 and VEGFR2 to inhibit angiogenesis. Long term dysregulation of NO signaling is a hallmark for several types of cardiovascular diseases, which makes CD47 a promissing target for atherosclerosis. Indeed, Anti-CD47 mAb has been demonstrated to reduce the atherosclerotic burden in several in vivo models.
Given its significant role in pathogenesis of cancer and cardiovascular diseases, there is no surprise that CD47 signaling has been heavily investigated for new targeted therapeutics. ACROBiosystems provides a unique set of CD47-relevant products, including mutilple avi tag pre-biotinylated proteins, for rapid high throughput screening. The following pairs of products can be easily adapted to ELISA, Alphalisa, and MSD platform to screen neutralizing compound.
|Pairs||Cat. No.||Product Description||Structure||Purity||Features|
|Pair 1||CD7-H82F6||Biotinylated Human CD47, Fc Tag, Avi Tag|
|Pair 1||SIA-H5225||Human SIRP alpha (HPLC-verified)|
|Pair 2||CD7-H82E9||Biotinylated Human CD47, Avi Tag|
|Pair 2||SIA-H5251||Human SIRP alpha, Fc Tag (HPLC-verified)|
|Pair 3||CD7-H5227||Human CD47 Protein|
|Pair 3||CDA-H82F2||Biotinylated Human SIRP alpha, Fc, Avi Tag|
We also offer mouse Fc tagged CD47 and SIRP alpha in case human Fc-tag interferes with your assay design. These products are uniquely suitable to bind with humanized antibodies.
|Molecule||Cat. No.||Product Description||Structure||Purity||Features|
|CD47||CD7-H52A5||Human CD47, mouse IgG2a Fc Tag, low endotoxin|
|SIRP alpha||SIA-H52A8||Human SIRP alpha, mouse IgG1 Fc Tag (HPLC-verified)|
In addition, we also provide CD47 from other commonly used experimental animal species.
|Cat. No.||Species||Product Description||Structure||Purity|
|CD7-C5252||CD47 Protein, Fc Tag|
|CD7-R5257||CD47 Protein, Fc Tag|
|CD7-R5256||CD47 Protein, Fc Tag|
|CD7-M5251||CD47 Protein, Fc Tag|
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