Login Register
icon_bulk_orderBulk order Acrobiosystems for English
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > IL-10 R alpha

IL-10 R alpha

Product ListCompare or Buy

Part of Bioactivity data

ILR-H525a-BLI
 IL-10 R alpha BLI

Loaded Human IL-10 R alpha / CD210, Fc Tag (Cat. No. ILR-H525a) on Protein A Biosensor, can bind Human IL-10, His Tag (Cat. No. IL0-H4248) with an affinity constant of 1.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ILR-C5256-BLI
 IL-10 R alpha BLI

Loaded Cynomolgus IL-10 R alpha / CD210, Fc Tag (Cat. No. ILR-C5256) on Protein A Biosensor, can bind Human IL-10, His Tag (Cat. No. IL0-H4248) with an affinity constant of 0.96 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

Interleukin-10 receptor subunit alpha,IL-10 receptor subunit alpha,IL-10R subunit alpha,IL-10RA,CDw210a,Interleukin-10 receptor subunit 1,IL-10R subunit 1,IL-10R1,CD210,IL10RA,IL10R

Background

Interleukin-10 receptor subunit alpha (IL-10 R alpha ) is a cell surface receptor for the cytokine IL-10 that participates in IL-10 mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well.In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively.These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3.

Clinical and Translational Updates

This web search service is supported by Google Inc.

totop
Call us
Call us
North America: +1 800-810-0816 (Toll Free)
Asia & Pacific: +86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message