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Your Position: Home > IL-10 R alpha

IL-10 R alpha

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Cat. No. Species Product Description Structure Purity Feature
ILR-M5254 Mouse Mouse IL-10 R alpha / CD210 Protein, Fc Tag
ILR-M5254-structure
ILR-H525a Human Human IL-10 R alpha / CD210 Protein, Fc Tag (MALS verified)
ILR-H525a-structure
ILR-H525a-sds
ILR-C5256 Cynomolgus Cynomolgus IL-10 R alpha / CD210 Protein, Fc Tag
ILR-C5256-structure
ILR-C5256-sds
ILR-H82F6 Human Biotinylated Human IL-10 R alpha / CD210 Protein, Fc,Avitag™ (MALS verified)
ILR-H82F6-structure
ILR-H82F6-sds
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Part of Bioactivity data

ILR-H525a-BLI
IL-10 R alpha BLI

Loaded Human IL-10 R alpha / CD210, Fc Tag (Cat. No. ILR-H525a) on Protein A Biosensor, can bind Human IL-10, His Tag (Cat. No. IL0-H4248) with an affinity constant of 1.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
ILR-C5256-BLI
IL-10 R alpha BLI

Loaded Cynomolgus IL-10 R alpha / CD210, Fc Tag (Cat. No. ILR-C5256) on Protein A Biosensor, can bind Human IL-10, His Tag (Cat. No. IL0-H4248) with an affinity constant of 0.96 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

Interleukin-10 receptor subunit alpha,IL-10 receptor subunit alpha,IL-10R subunit alpha,IL-10RA,CDw210a,Interleukin-10 receptor subunit 1,IL-10R subunit 1,IL-10R1,CD210,IL10RA,IL10R

Background

Interleukin-10 receptor subunit alpha (IL-10 R alpha ) is a cell surface receptor for the cytokine IL-10 that participates in IL-10 mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well.In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively.These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3.

Clinical and Translational Updates

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