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Your Position: Home > HGF R

HGF R

Brief Information

Name:Hepatocyte growth factor receptor
Target Synonym:EC 2.7.10,EC:2.7.10.1,HGF receptor,HGF/SF receptor,Hepatocyte growth factor receptor,Tyrosine-protein kinase Met,MET,SF receptor,Scatter factor receptor,MET Proto-Oncogene, Receptor Tyrosine Kinase,Proto-Oncogene C-Met,Met Proto-Oncogene,EC 2.7.10.1,DFNB97,AUTS9,RCCP2,C-Met,HGFR,Proto-Oncogene Proteins c-met
Number of Launched Drugs:7
Number of Drugs in Clinical Trials:44
Lastest Research Phase:Approved

Licensing

Project item Indications Research phase Cooperation demands
BNO202202 Gastric cancer, solid tumor IND Approval License-out or co-development

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Part of Bioactivity data

MET-C52H9-ELISA
Cynomolgus HGF R, His TagCynomolgus HGF R, His Tag (Cat. No. MET-C52H9) ELISA bioactivity

Immobilized Cynomolgus HGF R, His Tag (Cat. No. MET-C52H9) at 5 μg/mL (100 μL/well) can bind Human HGF, Fc Tag (Cat. No. HGF-H5253) with a linear range of 0.6-20 ng/mL (QC tested).

MET-R52H9-MALS-HPLC
HGF R MALS images

The purity of Rabbit HGF R / c-MET, His Tag (Cat. No. MET-R52H9) is more than 85% and the molecular weight of this protein is around 103-125 kDa verified by SEC-MALS.

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Synonym Name

MET,AUTS9,HGFR,RCCP2,c-Met

Background

The SARS-CoV-2 Spike S2-coupled Magnetic Beads is produced by coupling biotinylated SARS-CoV-2 spike S2 protein to streptavidin-conjugated magnetic beads. Because Streptavidin (SA) has an extraordinarily high affinity for biotin with a dissociation constant (Kd) on the order of 10-14 mol/L, the biotinylated protein can bind to the SA beads irreversibly. The pre-coupled beads are ready to use for capturing anti-SARS-CoV-2 antibody or ACE2 protein from your sample with high specificity.

Clinical and Translational Updates

Related Molecule

HGF

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Capmatinib Hydrochloride NVP-INC280-NX; INCB-28060; C2A374O70X; INC-280; INCB-028060 Approved Novartis Pharma Ag, Incyte Corp Tabrecta EU Carcinoma, Non-Small-Cell Lung Novartis Europharm Ltd 2020-05-06 Triple Negative Breast Neoplasms; Carcinoma, Hepatocellular; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Hepatic Insufficiency; Colorectal Neoplasms; Gliosarcoma; Sarcoma; Liver Neoplasms; Adenocarcinoma of Lung; Neoplasms; Glioblastoma; Carcinoma; Carcinoma, Renal Cell; Skin Melanoma; Kidney Neoplasms; Solid tumours Details
Savolitinib HM-5016504; AZD-6094; HMP-504; HMPL-504 Approved Hutchison Medipharma Ltd 沃瑞沙, ORPATHYS Mainland China Carcinoma, Non-Small-Cell Lung Hutchison Medipharma Ltd 2021-06-22 Cholangiocarcinoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Carcinosarcoma; Carcinoma, Squamous Cell; Glioma; Neoplasms, Neuroepithelial; Colorectal Neoplasms; Peritoneal Neoplasms; Diffuse Intrinsic Pontine Glioma; Urologic Neoplasms; Kidney Neoplasms; Central Nervous System Neoplasms; Colonic Neoplasms; Kidney Diseases; Neoplasms; Rectal Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma; Carcinoma, Renal Cell; Solid tumours; Medulloblastoma Details
Tepotinib hydrochloride hydrate EMD-1214063; MSC-2156119; MSC-2156119J Approved Merck Serono Tepmetko, テプミトコ, TEPMETKO EU Carcinoma, Non-Small-Cell Lung Merck KGaA, Darmstadt, Germany 2020-03-25 Solid tumours; Hepatic Insufficiency; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Crizotinib PF-1066; PF-2341066; PF-02341066; PF-002341066 Approved Pfizer Pharmaceuticals Ltd (China) 赛可瑞, Xalkori EU Lymphoma, Large-Cell, Anaplastic Pfizer Europe Ma Eeig 2011-08-26 Neuroblastoma; Neoplasm Metastasis; Neurilemmoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Granuloma, Plasma Cell; Lymphoma; Lung Neoplasms; Lymphoma, Large-Cell, Anaplastic; Ureteral Neoplasms; Hematologic Neoplasms; Urethral Neoplasms; Myofibroma; Prostatic Neoplasms, Castration-Resistant; Uveal melanoma; Multiple Myeloma; Urinary Bladder Neoplasms; Kidney Diseases; Neurofibromatosis 2; Neoplasms; Solid tumours Details
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx Japan Carcinoma, Renal Cell Takeda 2012-11-29 Osteosarcoma; Thyroid Neoplasms; Gliosarcoma; Colorectal Neoplasms; Peritoneal Neoplasms; Bile Duct Neoplasms; Hepatic Insufficiency; Astrocytoma; Breast Neoplasms; Sarcoma, Ewing; Lymphoma; Carcinoma, Adenosquamous; Adenocarcinoma, Clear Cell; Sarcoma, Clear Cell; Medullary thyroid cancer (MTC); Cholangiocarcinoma; Prostatic Neoplasms; Neurofibroma, Plexiform; Urethral Neoplasms; Carcinoma, Neuroendocrine; Meningioma; Carcinoma, Non-Small-Cell Lung; Paraganglioma; Melanoma; Carcinoma, Endometrioid; Thyroid Cancer, Papillary; Adenocarcinoma; Neoplasms, Germ Cell and Embryonal; Carcinoma, Hepatocellular; Neuroblastoma; Glioma; Leukemia, Myeloid, Acute; Carcinoma, Squamous Cell; Endometrial Neoplasms; Lung Neoplasms; Sarcoma, Alveolar Soft Part; Uterine Neoplasms; Fallopian Tube Neoplasms; Carcinoid Tumor; Neurofibromatoses; Seminoma; Carcinoma, Transitional Cell; Glioblastoma; Rejection of liver transplantation; Carcinoma, Merkel Cell; Hepatoblastoma; Pain; Pheochromocytoma; Neoplasms; Carcinoma, Renal Cell; B Details
Amivantamab JNJ-372; JNJ-61186372 Approved Janssen Global Services Llc, Genmab A/S RYBREVANT Canada Carcinoma, Non-Small-Cell Lung Janssen Inc 2021-05-21 Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Colorectal Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Ensartinib Hydrochloride X-396 Approved Xcovery 贝美纳 Mainland China Carcinoma, Non-Small-Cell Lung Betta Pharmaceuticals Co Ltd 2020-11-17 Histiocytosis, Langerhans-Cell; Carcinoma, Hepatocellular; Xanthogranuloma, Juvenile; Neuroectodermal Tumors, Primitive, Peripheral; Neoplasms, Germ Cell and Embryonal; Carcinoma, Non-Small-Cell Lung; Neoplasms, Neuroepithelial; Glioma; Carcinoma, Squamous Cell; Lymphoma, Non-Hodgkin; Brain metastases; Lung Neoplasms; Histiocytic Sarcoma; Solid tumours; Neuroblastoma; Sarcoma, Ewing; Osteosarcoma; Sarcoma; Central Nervous System Neoplasms; Neoplasms; Wilms Tumor; Rhabdoid Tumor; Hepatoblastoma; Medulloblastoma; Ependymoma; Rhabdomyosarcoma Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SAIT-301 SAIT-301 Phase 1 Clinical Neoplasms Details
NP-01 (Shijiazhuang No.4 Pharmaceutical/Nanjing Nadingfei Medical Technology) NP-01 Phase 1 Clinical Shijiazhuang No 4 Pharmaceutical Co Ltd, Nanjing Nadingfei Pharmaceutical Technology Co Ltd Liver Neoplasms; Solid tumours; Stomach Neoplasms; Lung Neoplasms Details
LMV-12(HE003) LMV-12(HE003) Phase 1 Clinical Nanchang Hongyi Technology Co Ltd Solid tumours Details
Pamufetinib TAS-115 Phase 1 Clinical Otsuka Pharmaceutical Co Ltd, Taiho Pharmaceutical Co Ltd Neoplasms Details
NP-107 NP107; NP-107 Phase 1 Clinical Shanghai Nawei Biotechnology Co Ltd Solid tumours Details
Boxitinib Hydrochloride Phase 1 Clinical Hec Pharm Co Ltd Stomach Neoplasms; Carcinoma, Renal Cell; Breast Neoplasms; Glioma; Lung Neoplasms Details
Alirinetide GM-606; GM-607; GM-608; GM-609; GM-6; GM-600; GM-602; GM-603; GM-604; GM-605 Genervon Biopharmaceuticals Llc Details
LM-061 LM-061 Phase 1 Clinical Shanghai Lixin Pharmaceutical Research and Development Co Ltd Solid tumours Details
HTI-1066 HTI-1066 Jiangsu Hengrui Medicine Co Ltd Details
SGX-523 SGX-523 Eli Lilly And Company Details
HLX-55 HLX-55; KTN-0216 Phase 1 Clinical Kolltan Pharmaceuticals Inc Solid tumours Details
BPI-9016 BPI-9016; BPI-9016M Phase 1 Clinical Betta Pharmaceuticals Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
EMD-1204831 EMD-1204831 Merck Serono Details
PF-04217903 PF-4217903; PF-04217903; PF-4217903-A Pfizer Pharmaceuticals Ltd (China) Details
JNJ-38877605 JNJ-38877605 Johnson & Johnson Details
c-Met/PD-L1 CAR-T cell (The Second Hospital of Nanjing Medical University) The Second Hospital Of Nanjing Medical University Details
Anti-cMet SIMPLE Antibody ARGX-111 Argenx Se Details
Metatinib Trometamol BMS-817378; SIM-817378 Phase 1 Clinical Bristol-Myers Squibb Company Solid tumours; Liver Neoplasms; Stomach Neoplasms; Colorectal Neoplasms Details
QBH-196 QBH-196 Phase 1 Clinical Shenyang Pharmaceutical University Solid tumours; Stomach Neoplasms Details
Kanitinib CX-1003 Phase 1 Clinical Beijing Konruns Pharmaceutical Co Ltd, Guangzhou Yingsheng Bio Technology Co Ltd Solid tumours Details
CKD-702 Phase 1 Clinical Chong Kun Dang Pharmaceutical Corp Carcinoma, Non-Small-Cell Lung Details
Fosgonimeton ATH-1017; NDX-1017 Phase 3 Clinical M3 Biotechnology Alzheimer Disease; Lewy Body Disease Details
REGN-5093-M114 METxMET-M114; REGN5093-M114 Phase 2 Clinical Regeneron Pharmaceuticals Inc Carcinoma, Non-Small-Cell Lung Details
REGN-5093 REGN-5093 Phase 2 Clinical Regeneron Pharmaceuticals Inc Carcinoma, Non-Small-Cell Lung Details
BYON-3521 BYON-3521 Phase 1 Clinical Byondis Bv Solid tumours; Neoplasms Details
TR1801-ADC MT-8633; TR1801-ADC Phase 1 Clinical Tanabe Research Laboratories U.S.A. Inc Solid tumours Details
ASKC-202 ASKC202 Phase 1 Clinical Solid tumours Details
Recombinant plasmid-hepatocyte growth factor Pudk-HGF Phase 3 Clinical Academy Of Military Medical Sciences, Wuhan Optical Valley Humanwell Biological Pharmaceutical Co Ltd Ischemia; Peripheral Arterial Disease Details
Elzovantinib TPX-0022 Phase 2 Clinical Turning Point Therapeutics Inc Solid tumours; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung Details
AL-2846 AL-2846 Phase 2 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Advenchen Laboratories Nanjing Ltd Bone metastases; Liver Neoplasms; Stomach Neoplasms; Neurofibromatoses; Neoplasms; Pancreatic Neoplasms; Neurofibroma; Ganglioglioma; Medullary thyroid cancer (MTC); Prostatic Neoplasms; Colorectal Neoplasms; Neurilemmoma; Carcinoma, Non-Small-Cell Lung; Neurofibromatosis 1 Details
Emibetuzumab LA-480; LY-2875358 Phase 2 Clinical Eli Lilly And Company Solid tumours; Liver Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Neoplasms; Lymphoma; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
SPH3348 SPH-3348 Phase 1 Clinical Shanghai Pharmaceuticals Holding Co Ltd Solid tumours; Neoplasms Details
GB-263 GB-263; GB-263T Phase 2 Clinical Genor Biopharma Co Ltd Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Glesatinib 7Q29OXD98N; MG-90265H9; MG-90265gly; MG-90265; MG-90265X; MGCD-265 Phase 2 Clinical Mirati Therapeutics Inc Neoplasms; Carcinoma, Non-Small-Cell Lung Details
ABN-401 ABN-401; KDDF-201603-08 Phase 2 Clinical Abion Inc Solid tumours; Neoplasms Details
CM-118 CM-118 Phase 1 Clinical Xcovery Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Merestinib LY-2801653; 5OGS5K699E Phase 2 Clinical Eli Lilly And Company Bone metastases; Solid tumours; Biliary Tract Neoplasms; Skin Melanoma; Pancreatic Neoplasms; Neoplasms; Microsatellite instability-high cancer; Breast Neoplasms; Lymphoma, Mantle-Cell; Cholangiocarcinoma; Colorectal Neoplasms; Lymphoma, Non-Hodgkin; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
HS-10241 HS-10241 Phase 1 Clinical Jiangsu Hansoh Pharmaceutical Group Co Ltd Solid tumours; Carcinoma; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Bafisontamab FIT-013a; EMB-01 Phase 2 Clinical Shanghai Epimab Biotherapeutics, Inc Liver Neoplasms; Biliary Tract Neoplasms; Carcinoid Tumor; Stomach Neoplasms; Neoplasms; Digestive System Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular Details
MCLA-129 MCLA-129 Phase 2 Clinical Merus Nv Solid tumours; Head and Neck Neoplasms; Stomach Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
TAVO-412 TAVO-412 Phase 1 Clinical Tavotek Biotherapeutics (Hong Kong) Ltd Neoplasms Details
EMI-137 EMI-137; GE-137 Phase 2 Clinical Ge Healthcare Esophageal Neoplasms; Colonic Neoplasms; Barrett Esophagus Details
GST-HG161 GST-HG161 Phase 1 Clinical Wuxi Apptec Co Ltd, Fujian Cosunter Pharmaceutical Co Ltd Solid tumours; Neoplasms; Carcinoma, Hepatocellular Details
Telisotuzumab vedotin ABT-399; ABBV-399 Phase 3 Clinical Abbvie Inc Solid tumours; Carcinoma, Non-Small-Cell Lung Details
XL-092 XL-092 Phase 3 Clinical Exelixis Inc Solid tumours; Carcinoma, Renal Cell; Neoplasms; Carcinoma, Transitional Cell; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Colorectal Neoplasms Details
Ningetinib Tosylate CT-053-PTSA; CT-053 Phase 2 Clinical Hec Pharm Co Ltd Solid tumours; Intestinal Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Lung Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
RC-108 RC-108; RC108 Phase 2 Clinical RemeGen Co Ltd Solid tumours; Digestive System Neoplasms; Gastrointestinal Neoplasms Details
Sitravatinib IND-155305; MG-516; MG-91516; MGCD-516 Phase 3 Clinical Mirati Therapeutics Inc Breast Neoplasms; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Carcinoma, Squamous Cell; Mouth Neoplasms; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Hepatic Insufficiency; Ureteral Neoplasms; Kidney Neoplasms; Liposarcoma; Lung Diseases; Uveal melanoma; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Carcinoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Biliary Tract Neoplasms; Solid tumours Details
Refanalin ANG-3777; BB-3; SNV-003 Phase 3 Clinical Vifor Pharma Ag, Angion Biomedica Corp Pneumonia; Myocardial Infarction; Coronavirus Disease 2019 (COVID-19); Delayed Graft Function; Acute Kidney Injury Details
CBT-101 CBT-101 Phase 1 Clinical Solid tumours Details
AMG-337 AMG-337 Phase 2 Clinical Amgen Inc Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Sarcoma, Clear Cell; Esophageal adenocarcinoma; Adenocarcinoma; Gastrointestinal Neoplasms Details

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