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DPPIV

DPPIV Molecule Information

Name:Dipeptidyl peptidase IV
Target Synonym:DPPIV,Dipeptidyl peptidase IV membrane form,T-cell activation antigen CD26,Adenosine deaminase complexing protein 2,Dipeptidyl peptidase IV soluble form,ADCP2,Dipeptidyl peptidase 4,ADCP-2,DPP4,Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing
Number of Launched Drugs:28
Number of Drugs in Clinical Trials:22
Lastest Research Phase:Approved

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DPPIV Part of Bioactivity data

DP4-H5211-MALS-HPLC
Human DPPIV, Tag Free (Cat. No. ) MALS images

The purity of Human DPPIV, Tag Free (Cat. No. DP4-H5211) was more than 95% and the molecular weight of this protein is around 190-220 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GP-AMC). The specific activity is >11000 pmol/min/µg (QC tested).

DP4-H5221-MALS-HPLC
Human DPPIV, His Tag (Cat. No. ) MALS images

The purity of Human DPPIV, His Tag (Cat. No. DP4-H5221) was more than 95% and the molecular weight of this protein is around 190-220 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GP-AMC). The specific activity is >8500 pmol/min/µg (QC tested).

DPPIV Molecule Synonym Name

Kameoka J, et al.,1993, Science, 261 (5120): 466-9.

DPPIV Molecule Background

Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

DPPIV References

DPPIV Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride Approved Astrazeneca Plc Qtern United States Diabetes Mellitus, Type 2 s:14:"Astrazeneca Ab"; 2016-07-15 Diabetes Mellitus, Type 2 Details
Sitagliptin/Ertugliflozin Approved Pfizer Pharmaceuticals Ltd (China) Steglujan EU Diabetes Mellitus, Type 2 s:22:"Merck Sharp & Dohme Bv"; 2017-12-19 Diabetes Mellitus, Type 2 Details
Dapagliflozin/Saxagliptin/Metformin hydrochloride Approved Astrazeneca Pharmaceutical Co Ltd Qtrilmet, Qternmet XR United States Diabetes Mellitus, Type 2 s:14:"Astrazeneca Ab"; 2019-05-02 Diabetes Mellitus, Type 2 Details
Sitagliptin Tartrate Approved Heumann Pharma Gmbh & Co. Generica Kg Sitagliptin Heumann 25 mg Filmtabletten 欧洲联盟 s:37:"Heumann Pharma Gmbh & Co. Generica Kg"; 2020-12-14 Details
Saxagliptin Hydrochloride/Metformin Hydrochloride Approved Astrazeneca Pharmaceutical Co Ltd 安立格, Komboglyze, Kombiglyze Xr Mainland China Diabetes Mellitus, Type 2 s:14:"Astrazeneca Ab"; 2010-11-05 Diabetes Mellitus, Type 2 Details
Alogliptin Benzoate SYR-322; TAK-322 Approved Takeda 尼欣那, Nesina, Vipidia EU Diabetes Mellitus, Type 2 s:17:"Takeda Pharma A/S"; 2010-04-06 Diabetes Mellitus, Type 2; Acute Coronary Syndrome; Diabetes Mellitus Details
Evogliptin DA-1229 Approved Dong-A Pharmaceutical Co Ltd Suganon, Sugarnon South Korea Diabetes Mellitus, Type 2 s:28:"Dong-A Pharmaceutical Co Ltd"; 2015-10-02 Diabetes Mellitus, Type 2; Kidney Diseases; Aortic valve diseases; Liver Diseases Details
Metformin Hydrochloride/Sitagliptin Hydrochloride Approved Sandoz Bv EU s:9:"Sandoz Bv"; 2019-12-10 Details
Vildagliptin LAF-237; DSP-7238; LAF-237A; NVP-LAF-237 Approved Novartis Pharma Ag 佳维乐, Equa, Jalra, Galvus, Gliptus, Xiliarx Mainland China Diabetes Mellitus, Type 2 s:22:"Novartis Europharm Ltd"; 2007-09-25 Prediabetic State; Diabetes Mellitus, Type 2; Renal Insufficiency; Kidney Diseases; Diabetes Mellitus Details
Sitagliptin Phosphate/Metformin Hydrochloride Approved Merck & Co Inc Janumet, Velmetia Mainland China Diabetes Mellitus, Type 2 s:30:"Msd Pharma (Singapore) Pte Ltd"; 2007-03-30 Diabetes Mellitus, Type 2 Details
Linagliptin/Empagliflozin BI 10773/BI 1356; BI 1356/BI 10773; BI 10773/linagliptin; Linagliptin/BI 10773; BI 1356/empagliflozin; Empagliflozin/BI 1356 Approved C.H. Boehringer Sohn Ag & Co. Kg Glyxambi, Tradiance United States Cardiovascular Diseases s:25:"Boehringer Ingelheim Gmbh"; 2015-01-30 Diabetes Mellitus, Type 2; Cardiovascular Diseases Details
Linagliptin/Metformin Hydrochloride Approved Boehringer Ingelheim Gmbh 欧双宁, Jentadueto, Trajenta Duo, Jentadueto Xr Mainland China Diabetes Mellitus, Type 2 s:35:"Boehringer Ingelheim (Schweiz) Gmbh"; 2012-01-30 Diabetes Mellitus, Type 2 Details
Sitagliptin Phosphate Monohydrate MK-431; MK-0431; ONO-5435; ONO-5435A; L-000224715 Approved Merck Sharp & Dohme Corp 捷诺维, Glactiv, Januvia, Tesavel, Xelevia, Ristaben Japan Diabetes Mellitus, Type 2 s:51:"Ono Pharmaceutical Co Ltd, Merck Sharp & Dohme Corp"; 2006-10-16 Diabetes Mellitus, Type 2; Renal Insufficiency; Glucose Intolerance; Dyslipidemias; Hepatic Insufficiency; Kidney Failure, Chronic; Diabetes Mellitus Details
Saxagliptin Hydrate OPC-262; BMS-477118; BMS-477118-11 Approved Bristol-Myers Squibb Company 安立泽, Onglyza Japan Diabetes Mellitus, Type 2 s:24:"Kyowa Hakko Kirin Co Ltd"; 2009-07-31 Diabetes Mellitus, Type 2; Diabetes Mellitus Details
Gemigliptin L-tartrate Sesquihydrate LC-150444; LC-15-0444 Approved Lg Life Sciences Ltd Gemiglo, Zemiglo South Korea Diabetes Mellitus, Type 2 s:20:"Lg Life Sciences Ltd"; 2012-06-27 Diabetes Mellitus, Type 2; Hepatic Insufficiency Details
Alogliptin Benzoate/Metformin Hydrochloride Approved Takeda Pharmaceutical Co Ltd Kazano, Inisync, Vipdomet Japan Diabetes Mellitus, Type 2 s:6:"Takeda"; 2013-01-25 Diabetes Mellitus, Type 2 Details
Alogliptin Benzoate/Pioglitazone Hydrochloride SYR-322-4833 BL Approved Takeda Pharmaceutical Co Ltd Oseni, Liovel, Incresync, Nesinaact EU Diabetes Mellitus, Type 2 s:17:"Takeda Pharma A/S"; 2011-07-01 Diabetes Mellitus, Type 2 Details
Vildagliptin/Metformin Hydrochloride LMF-237 Approved Novartis Pharma Ag 宜合瑞, EquMet, Eucreas, Icandra, Zomarist Japan Diabetes Mellitus, Type 2 s:18:"Novartis Pharma Ag"; 2007-11-14 Diabetes Mellitus, Type 2 Details
Linagliptin BI-1356; BI-1356-BS Approved Boehringer Ingelheim Gmbh 欧唐宁, Ondero, Trajenta, Trayenta, Trazenta, Tradjenta Mainland China Diabetes Mellitus, Type 2 s:39:"Boehringer Ingelheim International Gmbh"; 2011-05-02 Diabetes Mellitus, Type 2; Albuminuria; Renal Insufficiency; Carcinoma, Transitional Cell; Hypertension; Urinary Bladder Neoplasms; Hepatic Insufficiency Details
Sitagliptin Hydrochloride Approved EU Diabetes Mellitus, Type 2 s:21:"Laboratorios Alter Sa"; 2018-11-27 Diabetes Mellitus, Type 2 Details
Omarigliptin MK-3102 Approved Merck & Co Inc Marizev Japan Diabetes Mellitus, Type 2 s:24:"Merck Sharp & Dohme Corp"; 2015-09-28 Diabetes Mellitus, Type 2; Renal Insufficiency, Chronic Details
Evogliptin Tartrate/Metformin Hydrochloride DA-1229_01 Approved Dong-A Pharmaceutical Co Ltd Sugamet XR South Korea Diabetes Mellitus, Type 2 s:28:"Dong-A Pharmaceutical Co Ltd"; 2015-12-01 Diabetes Mellitus, Type 2 Details
Trelagliptin Succinate SYR-111472 succinate; SYR-111472; TAK-472; SYR-472 Approved Takeda Pharmaceutical Co Ltd Zafatek Japan Diabetes Mellitus, Type 2 s:6:"Takeda"; 2015-03-26 Diabetes Mellitus, Type 2; Diabetes Mellitus Details
Anagliptin SK-0403; CWP-0403 Approved Sanwa Kagaku Kenkyusho Co Ltd Suiny, Beskoa Japan Diabetes Mellitus, Type 2 s:4:"null"; 2012-09-28 Diabetes Mellitus, Type 2 Details
Anagliptin/Metformin Hydrochloride SK-1501 Approved Sanwa Kagaku Kenkyusho Co Ltd, Suzuken Metoana Japan Diabetes Mellitus, Type 2 s:29:"Sanwa Kagaku Kenkyusho Co Ltd"; 2018-09-21 Diabetes Mellitus, Type 2 Details
Teneligliptin Hydrobromide Hydrate/Canagliflozin Hemihydrate Approved Mitsubishi Tanabe Pharma Corp, Daiichi Sankyo Co Ltd Canalia Japan Diabetes Mellitus, Type 2 s:47:"Daiichi Sankyo Co Ltd, Mitsubishi Tanabe Pharma"; 2017-07-03 Diabetes Mellitus, Type 2 Details
Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline MK-0431J Approved Merck & Co Inc, Astellas Pharma Inc Sujanu Japan Diabetes Mellitus, Type 2 s:4:"null"; 2018-03-23 Diabetes Mellitus, Type 2 Details
Empagliflozin/Linagliptin/Metformin Approved Boehringer Ingelheim Gmbh, Eli Lilly And Company Trijardy XR United States Diabetes Mellitus, Type 2 s:25:"Boehringer Ingelheim Gmbh"; 2020-01-27 Diabetes Mellitus, Type 2 Details
Teneligliptin Hydrobromide Hydrate/Metformin Hydrochloride Approved Handok Inc Tenelia M SR South Korea Diabetes Mellitus, Type 2 s:10:"Handok Inc"; 2015-11-03 Diabetes Mellitus, Type 2 Details
Teneligliptin Hydrobromide Hydrate MP-513 Approved Mitsubishi Tanabe Pharma Tenelia, Tenglyn Japan Diabetes Mellitus, Type 2 s:47:"Daiichi Sankyo Co Ltd, Mitsubishi Tanabe Pharma"; 2012-06-29 Diabetes Mellitus, Type 2 Details
Gemigliptin L-tartrate Sesquihydrate/Metformin Hydrochloride Approved Lg Life Sciences Ltd ZemiMet SR South Korea Diabetes Mellitus, Type 2 s:20:"Lg Life Sciences Ltd"; 2015-01-01 Diabetes Mellitus, Type 2 Details

DPPIV Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Bogliptin maleate HL012MA Phase 1 Clinical Shanghai Runshi Pharmaceutical Technology Co Ltd Solid tumours Details
TSL-0319 TSL-0319 Phase 1 Clinical Jiangsu Tasly Diyi Pharmaceutical Co Ltd Diabetes Mellitus, Type 2 Details
Linagliptin/Fimasartan Potassium Trihydrate Phase 1 Clinical Boryung Pharmaceutical Co Ltd Hypertension; Diabetes Mellitus Details
REC-04 Clinical Recardio Cardiovascular Diseases Details
YS-110 YSCMA; YS-110 Phase 2 Clinical Y'S Therapeutics Carcinoma, Renal Cell; Mesothelioma Details
Talabostat (BioXcel) PT-100; BXCL-701 Phase 2 Clinical Inveni Pancreatic Neoplasms; Prostatic Neoplasms Details
DC291407 DC-407; DC-291407 Phase 1 Clinical Cisen Pharmaceutical Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Diabetes Mellitus, Type 2 Details
CPL2009-0031 Phase 3 Clinical Cadila Healthcare Ltd Diabetes Mellitus, Type 2 Details
Sitagliptin/Telmisartan HOB-077; HDDO-1609; HDDO-16091 + HDDO-16092 Phase 1 Clinical Hyundai Pharmaceutical Hypertension; Diabetes Mellitus Details
Augliptin Hydrochloride Phase 1 Clinical Shanghai Yangfan Pharmaceutical Technology Co Ltd, Nanjing Chang'Ao Medicine Technology Co Ltd Diabetes Mellitus, Type 2 Details
Dutogliptin Tartrate REC-01; PHX-1149; PHX-1149T Phase 2 Clinical Phenomix Diabetes Mellitus, Type 2; Myocardial Infarction; ST Elevation Myocardial Infarction; Kidney Diseases; Leukemia, Myeloid, Acute Details
Lobeglitazone/Sitagliptin CKD-396 Phase 1 Clinical Chong Kun Dang Pharmaceutical Corp Diabetes Mellitus, Type 2 Details
Rosuvastatin Calcium/Gemigliptin L-tartrate Sesquihydrate Phase 3 Clinical Lg Life Sciences Ltd Diabetes Mellitus, Type 2; Dyslipidemias Details
Fotagliptin Benzoate Phase 3 Clinical Chongqing Fuchuang Pharmaceuticals Research Co Ltd, Shanghai Fosun Industry Co Ltd Diabetes Mellitus, Type 2 Details
Cetagliptin Phosphate CGT-8012 Phase 3 Clinical Shengshi Taike Biological Medicine Technology (Suzhou) Co Ltd Diabetes Mellitus, Type 2 Details
Imigliptin Hydrochloride KBP-3853 Phase 2 Clinical Shandong Xuanzhu Pharmaceutical Technology Co Ltd, Beijing Sihuan Pharmaceutical Co Ltd Diabetes Mellitus, Type 2 Details
HD118 HD-118 Phase 1 Clinical Huadong Pharmaceutical Co Ltd, Hangzhou Zhongmei Huadong Pharmaceutical Co Ltd Diabetes Mellitus, Type 2 Details
Yogliptin Phase 2 Clinical Sichuan Sunheal Pharmaceutical Co Ltd, Chengdu Easton Biopharmaceuticals Co Ltd Diabetes Mellitus, Type 2 Details
Diabetes therapeutic DBPR-108 Phase 3 Clinical Taiwan Shenlong Co Ltd, National Health Research Institutes Diabetes Mellitus, Type 2 Details
Evogliptin Tartrate LY-05007 Phase 1 Clinical Dong-A Pharmaceutical Co Ltd Diabetes Mellitus, Type 2 Details
TQ-F3083 TQ-F3083 Phase 2 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Beijing Sailintai Medicine Technology Co Ltd Diabetes Mellitus, Type 2; Diabetes Mellitus Details
HSK-7653 HSK7653; HSK-7653 Phase 3 Clinical Liaoning Haisco Pharmaceutical Co Ltd, Sichuan Haisco Pharmaceutical Co Ltd Diabetes Mellitus, Type 2; Glucose Intolerance Details

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