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Brief Information

Name:Epidermal growth factor
Target Synonym:Epidermal Growth Factor (Beta-Urogastrone),Beta-Urogastrone,Urogastrone,URG,EGF,HOMG4,Epidermal Growth Factor,Pro-Epidermal Growth Factor
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Part of Bioactivity data

EGF-H52H3-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Response to human EGF protein (Fold). The EGFR (Luc) HEK293 Reporter Cell (Cat. No. CHEK-ATF049) was stimulated with serial dilutions of human EGF protein (AcroBiosystems, Cat. No. EGF-H52H3). The max induction fold was approximately 56 (Routinely tested).


Captured Mouse EGF R, His Tag (Cat. No. EGR-M5224) on CM5 Chip via anti-His antibody can bind Mouse EGF, Fc Tag (Cat. No. EGF-M5265) with an affinity constant of 5.44 nM as determined in SPR assay (Biacore T200 ) (Routinely tested).


Human EGF R, His Tag (Cat. No. EGR-H5222) captured on CM5 Chip via anti-His antibody can bind Human EGF, Mouse IgG2a Fc Tag (Cat. No. EGF-H525b) with an affinity constant of 2.63 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name



Human epidermal growth factor (EGF) is also known as HOMG4 and  URG,and is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. Epidermal growth factor can be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. All family members contain one or more repeats of the conserved amino acid sequence. The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents. Because of the increased risk of cancer by EGF, inhibiting it decreases cancer risk.

Clinical and Translational Updates

Related Molecule

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
PX-070101 PX-070101 Approved Praxis Pharmaceuticals Colombia Diabetic Foot Praxis Pharmaceuticals 2015-07-01 Diabetic Foot Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant anti-EGFR chimeric monoclonal antibody (Shanghai CP Guojian) CPGJ-602; 602; CPGJ602; CPGJ 602 Phase 2 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Colorectal Neoplasms Details

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