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Your Position: Home > EGF

EGF

Brief Information

Name:Epidermal growth factor
Target Synonym:Epidermal Growth Factor (Beta-Urogastrone),Beta-Urogastrone,Urogastrone,URG,EGF,HOMG4,Epidermal Growth Factor,Pro-Epidermal Growth Factor
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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By Product Status:
By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
EGF-H52H3 Human ActiveMax® Human EGF Protein, His Tag
EGF-H52H3-structure
EGF-H52H3-sds
EGF-M5265 Mouse Mouse EGF Protein, Fc Tag
EGF-M5265-structure
EGF-M5265-sds
EGF-H525b Human Human EGF Protein, Mouse IgG2a Fc Tag
EGF-H525b-structure
EGF-H525b-sds

Part of Bioactivity data

EGF-H52H3-Cell-based assay
 EGF CELL

Response to human EGF protein (Fold).
The EGFR (Luc) HEK293 Reporter Cell was stimulated with serial dilutions of human EGF protein (AcroBiosystems, Cat. No. EGF-H52H3). The max induction fold was approximately 56 (Routinely tested).

EGF-M5265-SPR
Human_FcRn_Heterodimer_Protein_SPR

Captured Mouse EGF R, His Tag (Cat. No. EGR-M5224) on CM5 Chip via anti-His antibody can bind Mouse EGF, Fc Tag (Cat. No. EGF-M5265) with an affinity constant of 5.44 nM as determined in SPR assay (Biacore T200 ) (Routinely tested).

EGF-H525b-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human EGF R, His Tag (Cat. No. EGR-H5222) captured on CM5 Chip via anti-His antibody can bind Human EGF, Mouse IgG2a Fc Tag (Cat. No. EGF-H525b) with an affinity constant of 2.63 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

EGF,URG,HOMG4

Background

Human epidermal growth factor (EGF) is also known as HOMG4 and  URG,and is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. Epidermal growth factor can be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. All family members contain one or more repeats of the conserved amino acid sequence. The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents. Because of the increased risk of cancer by EGF, inhibiting it decreases cancer risk.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant anti-EGFR chimeric monoclonal antibody (Shanghai CP Guojian) CPGJ-602; 602; CPGJ602; CPGJ 602 Phase 2 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Colorectal Neoplasms Details
EMD 55900 EMD-55900 Merck Serono Details

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