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GITR

GITR Molecule Information

Name:Glucocorticoid-induced tumor necrosis factor receptor-related protein
Target Synonym:Glucocorticoid-induced tumor necrosis factor receptor-related protein?CD357?AITR?GITR?Activation-inducible TNFR family receptor?TNFRSF18?UNQ319/PRO364?Glucocorticoid-induced TNFR-related protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:11
Lastest Research Phase:Phase ?

GITR Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
GIR-C52H6 Canine Canine GITR / TNFRSF18 Protein, His Tag
GIR-C52H6-structure
GIR-C52H6-sds
GIR-C52H6-elisa_1
GIR-H82F7 Human Biotinylated Human GITR / TNFRSF18 Protein, Fc Tag, Avi Tag (Avitag™)
GIR-H82F7-structure
GIR-H82F7-sds
GIR-H82E4 Human Biotinylated Human GITR / TNFRSF18 Protein, His Tag, Avi Tag (Avitag™)
GIR-H82E4-structure
GIR-H82E4-sds
GIR-H82E4-elisa_1
GIR-H525a Human Human GITR / TNFRSF18 Protein, Mouse IgG2a Fc Tag, low endotoxin
GIR-H525a-structure
GIR-H525a-sds
GIR-H525a-elisa_1
GIR-H5254 Human Human GITR / TNFRSF18 Protein, Fc Tag
GIR-H5254-structure
GIR-H5254-sds
GIR-H5254-elisa_1
GIR-C5255 Rhesus macaque Rhesus macaque GITR / TNFRSF18 Protein, Fc Tag
GIR-C5255-structure
GIR-C5255-sds
GIR-R5222 Rat Rat GITR / TNFRSF18 Protein
GIR-R5222-structure
GIR-R5222-sds
GIR-M5251 Mouse Mouse GITR / TNFRSF18 Protein, Fc Tag
GIR-M5251-structure
GIR-M5251-sds
GIR-R5253 Rat Rat GITR / TNFRSF18 Protein, Fc Tag
GIR-R5253-structure
GIR-R5253-sds
GIR-M5220 Mouse Mouse GITR / TNFRSF18 Protein
GIR-M5220-structure
GIR-M5220-sds
GIR-M5220-elisa_1
GIR-H5228 Human Human GITR / TNFRSF18 Protein, His Tag
GIR-H5228-structure
GIR-H5228-sds
GIR-H5228-elisa_1

GITR Molecule Synonym Name

AITR,GITR,TNFRSF18,CD357

GITR Molecule Background

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

GITR References

GITR Related Molecule

GITR Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ASP-1951 ASP-1951; PTZ-522 Phase Ⅰ Potenza Therapeutics, Astellas Solid tumours Details
Anti-GITR antibody (BMS) Phase Ⅰ Bristol-Myers Squibb Solid tumours Details
BMS-986256 Phase Ⅰ Bristol-Myers Squibb Cancer Details
MEDI-1873 MEDI-1873 Phase Ⅰ MedImmune Solid tumours Details
AMG-228 AMG-228 Phase Ⅰ Amgen Solid tumours Details
TRX-518 TRX-518 Phase Ⅰ Tolerx, Leap Therapeutics Solid tumours, Melanoma Details
ATOR-1144 ATOR-1144 Preclinical Alligator Bioscience hematological malignancies, Solid tumours Details
INCAGN-1876 INCAGN-1876 Phase Ⅱ Agenus, Ludwig Institute for Cancer Research, Incyte Solid tumours Details
GWN-323 GWN-323 Phase Ⅰ Novartis Solid tumours, Lymphoma Details
OMP-336B11 OMP-336B11; GITRL-Fc; GITRL-Fc trimer Phase Ⅰ OncoMed Pharmaceuticals Solid tumours Details
MK-4166 MK-4166 Phase Ⅰ Merck Sharp & Dohme Solid tumours Details

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