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GITR Molecule Information

Name:Glucocorticoid-induced tumor necrosis factor receptor-related protein
Target Synonym:Glucocorticoid-induced tumor necrosis factor receptor-related protein;CD357;AITR;GITR;Activation-inducible TNFR family receptor;TNFRSF18;UNQ319/PRO364;Glucocorticoid-induced TNFR-related protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Phase ?

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GITR Part of Bioactivity data

Canine GITR, His TagCanine GITR, His Tag (Cat. No. GIR-C52H6) ELISA bioactivity

Immobilized Canine GITR, His Tag (Cat. No. GIR-C52H6) at 2 μg/mL (100 μL/well) can bind Human GITR Ligand, Fc Tag (Cat. No. GIL-H526a) with a linear range of 2-40 ng/mL (QC tested).

Biotinylated Human GITR, His,Avitag™ (Cat. No. ) MALS images

The purity of Biotinylated Human GITR, His,Avitag™(Cat. No. GIR-H82E1) was more than 95% and the molecular weight of this protein is around 20-30 kDa verified by SEC-MALS.

Biotinylated Human GITR, His,Avitag™Biotinylated Human GITR, His,Avitag™ (Cat. No. GIR-H82E1) ELISA bioactivity

Immobilized Human GITR Ligand, Fc Tag (Cat. No. GIL-H5261) at 10 μg/mL (100 μL/well) can bind Biotinylated Human GITR, His,Avitag (Cat. No. GIR-H82E1) with a linear range of 0.2-8 ng/mL (QC tested).

GITR Customer Reviews

GITR Molecule Synonym Name


GITR Molecule Background

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

GITR References

GITR Related Molecule

GITR Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ASP-1951 ASP-1951; PTZ-522 Phase Ⅰ Potenza Therapeutics, Astellas Solid tumours Details
Anti-GITR antibody (BMS) Phase Ⅰ Bristol-Myers Squibb Solid tumours Details
MK-1248 MK-1248 Phase Ⅰ Merck Sharp & Dohme Solid tumours Details
Efgivanermin alfa MEDI-1873 Phase Ⅰ MedImmune Solid tumours Details
AMG-228 AMG-228 Phase Ⅰ Amgen Solid tumours Details
OMP-336B11 OMP-336B11 Phase Ⅰ OncoMed Pharmaceuticals Solid tumours Details
TRX-518 TRX-518 Phase Ⅱ Tolerx, Leap Therapeutics Prostate cancer, Solid tumours, Ovarian cancer, Melanoma Details
ATOR-1144 ATOR-1144 Preclinical Alligator Bioscience hematological malignancies, Solid tumours Details
INCAGN-1876 INCAGN-01876; INCAGN-1876 Phase Ⅱ Agenus, Ludwig Institute for Cancer Research, Incyte Solid tumours Details
GWN-323 GWN-323 Phase Ⅰ Novartis Solid tumours, Lymphoma Details
BMS-986156 BMS-986156,BMS 986156 Phase Ⅱ Bristol-Myers Squibb Solid tumours Details
MK-4166 MK-4166 Phase Ⅰ Merck Sharp & Dohme Solid tumours, Glioblastoma Details

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