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IGF-I Molecule Information

Name:Insulin-like growth factor I
Target Synonym:Insulin-like growth factor I;Somatomedin-C;IBP1;IGF1;MGF;Mechano growth factor;IGF-I
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
IG1-H4269 Human Human IGF-I Protein, Fc Tag

IGF-I Part of Bioactivity data

Human IGF-I, Fc TagHuman IGF-I, Fc Tag (Cat. No. IG1-H4269) ELISA bioactivity

Immobilized Human IGF-I, Fc Tag (Cat. No. IG1-H4269) at 5 μg/mL (100 μL/well) can bind Human IGFBP-3, His Tag (Cat. No. IG3-H5229) with a linear range of 0.031-0.5 μg/mL (QC tested).

tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6). Specific references are provided for interactions with IGFBP3, IGFBP4 and IGFBP7.

IGF-I References

IGF-I Related Molecule

IGF-I Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Mecasermin (Teva Pharmaceutical Industries) CEP-120; KW-6151 Phase Ⅲ Cephalon, Merck Sharp & Dohme, Kyowa Hakko Renal failure, Amyotrophic lateral sclerosis (ALS), Multiple sclerosis (MS), Peripheral  neuropathy Details
Xentuzumab BI-836845 Phase Ⅱ Boehringer Ingelheim Non small cell lung cancer (NSCLC), Prostate cancer, Breast cancer, Solid tumours Details
HF-0299 HF-0299; NPC-01,NPC01,HF0299 Phase Ⅰ LTT Institute, Newron Pharmaceutical Neuropathic pain Details
Dusigitumab MEDI-573 Phase Ⅱ MedImmune Breast cancer Details
FP-008 FP-008,FP008; FP 008 Preclinical Foresee Pharmaceuticals Diabetic retinopathy Details
IGF-drug conjugates (IGF Oncology) Preclinical IGF Oncology Cancer Details
ARX-201 ARX-201,ARX 201,ARX201 Phase Ⅱ Ambrx Somatotropin deficiency Details
AEW-541 AEW-541; NVP-AEW-541; NVP-AEW541-NX; NVP-AEW541-NX7 Phase Ⅰ Novartis Solid tumours, Haematological disorders Details

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