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Brief Information

Name:Insulin-like growth factor I
Target Synonym:IGF-I,Insulin-Like Growth Factor IB,Insulin-Like Growth Factor I,Somatomedin C,IGFI,IGF1A,IGF,IBP1,MGF,Mechano growth factor,IGF1,Insulin Like Growth Factor 1,Insulin-Like Growth Factor 1 (Somatomedin C),Somatomedin-C
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IG1-H4269 Human Human IGF-I Protein, Fc Tag

Part of Bioactivity data

Human IGF-I, Fc TagHuman IGF-I, Fc Tag (Cat. No. IG1-H4269) ELISA bioactivity

Immobilized Human IGF-I, Fc Tag (Cat. No. IG1-H4269) at 5 μg/mL (100 μL/well) can bind Human IGFBP-3, His Tag (Cat. No. IG3-H5229) with a linear range of 0.031-0.5 μg/mL (QC tested).

tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6). Specific references are provided for interactions with IGFBP3, IGFBP4 and IGFBP7.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HF-0299 NPC-01; HF-0299 Phase 1 Clinical Ltt Institute Dysmenorrhea; Neuralgia Details
Dusigitumab MEDI-573 Phase 2 Clinical Medimmune Llc Solid tumours; Breast Neoplasms; Carcinoma, Hepatocellular Details
Xentuzumab BI-836845 Phase 2 Clinical C.H. Boehringer Sohn Ag & Co. Kg Neoplasms; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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