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IL-2 R alpha

IL-2 R alpha Part of Bioactivity data

ILA-H82E6-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human IL-2 R alpha, His,Avitag (Cat. No. ILA-H82E6) inhibits the IL-2-dependent proliferation of Mo7e cells. The EC50 for this effect is 0.57-0.81 µg/mL (Routinely tested).

ILA-H52H9-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-2 R alpha, His Tag (Cat. No. ILA-H52H9) inhibits the IL-2 dependent proliferation of Mo7e cells. The EC50 for this effect is 0.35-0.77 µg/mL (Routinely tested).

ILA-H52H9-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-2 R alpha, His Tag (Cat. No. ILA-H52H9) captured on CM5 chip via anti-His antibody, can bind Human IL-2, Tag Free (Cat. No. IL2-H4113) with an affinity constant of 29.9 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

ILA-H82E6-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human IL-2 R alpha, His,Avitag (Cat. No. ILA-H82E6) on SA Biosensor, can bind Human IL-2, Tag Free (Cat. No. IL2-H4113) with an affinity constant of 70.2 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Cat. No. Species Product Description Structure Purity Feature
ILA-M52H9 Mouse Mouse IL-2 R alpha / CD25 Protein, His Tag
ILA-M52H9-structure
ILA-M52H9-sds
ILA-M52H9-elisa_1
ILA-H82E6 Human Biotinylated Human IL-2 R alpha / CD25 Protein, His,Avitag™
ILA-H82E6-structure
ILA-H82E6-sds
ILA-H82E6-elisa_1
ILA-H52H9 Human Human IL-2 R alpha / CD25 Protein, His Tag
ILA-H52H9-structure
ILA-H52H9-sds
ILA-H52H9-elisa_1
ILA-H52H9-elisa_2
ILA-H5251 Human Human IL-2 R alpha / CD25 Protein, Fc Tag
ILA-H5251-structure
ILA-H5251-sds
ILA-H5251-elisa_1

IL-2 R alpha Molecule Synonym Name

IL2RA,CD25,p55,IL2-RA,IL-2-RA

IL-2 R alpha Molecule Background

Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

IL-2 R alpha References

IL-2 R alpha Related Molecule

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