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Your Position: Home > IL-6

IL-6

Brief Information

Name:Interleukin-6
Target Synonym:CTL Differentiation Factor,Interleukin 6 (Interferon, Beta 2),HSF,B-cell stimulatory factor 2,Interferon beta-2,IL6,IFNB2,IL-6,Interleukin-6,Interleukin 6,Hybridoma Growth Factor,IFN-Beta-2,BSF-2,CDF,B-Cell Differentiation Factor,Interferon, Beta 2,Interleukin BSF-2,BSF2,HGF
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:18
Lastest Research Phase:Approved

Licensing

Project item Indications Research phase Cooperation demands
NSS-21001 Cancer cachexia Preclinical candidate compound identified License-out or co-development.

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Part of Bioactivity data

IL6-H8218-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human IL-6, epitope tag free, primary amine labeling (Cat. No. IL6-H8218) stimulates proliferation of TF-1 human erythroleukemic cell line. The EC50 for this effect is 0.2532-0.4489 ng/mL (Routinely tested).

IL6-H4218-Cell-based assay
 IL-6 CELL

Human IL-6, premium grade (Cat. No. IL6-H4218) stimulates proliferation of TF-1 human erythroleukemic cell line. The EC50 for this effect is 0.2856-0.3636 ng/mL (Routinely tested).

IL6-H8218-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human IL-6, epitope tag free, primary amine labeling (Cat. No. IL6-H8218) on SA Biosensor, can bind Human IL-6 R alpha, His Tag (Cat. No. ILR-H4223) with an affinity constant of 45.9 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL6-H4218-BLI
 IL-6 BLI

Loaded Human IL-6 R alpha, Fc Tag (Cat. No. ILR-H5259) on Protein A Biosensor, can bind Human IL-6, premium grade(Cat. No. IL6-H4218) with an affinity constant of 35.9 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL6,Interleukin-6,BSF2,HSF,IFNB2

Background

Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and  IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor  and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Luminol sodium MP-1032 Approved Selvim, Metrio Psoriasis; Immune System Diseases null 1997-01-01 Immune System Diseases; Psoriasis Details
Siltuximab cCLB-8; CNTO-328 Approved Johnson & Johnson Sylvant Mainland China Multicentric Castleman's Disease (MCD) Beigene (Beijing) Biotechnology Co Ltd 2014-04-23 Immunoglobulin Light-chain Amyloidosis; Leukemia, Large Granular Lymphocytic; Thrombocytopenia; Lymphoma, Non-Hodgkin; Lung Neoplasms; Primary Myelofibrosis; Colorectal Neoplasms; Castleman Disease; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms, Plasma Cell; Prostatic Neoplasms; Multicentric Castleman's Disease (MCD); Monoclonal Gammopathy of Undetermined Significance; Multiple Myeloma; Kidney Neoplasms; Myelodysplastic Syndromes; Pancreatic Neoplasms; Smoldering Multiple Myeloma; Psychotic Disorders; Polycythemia Vera; Carcinoma, Renal Cell; Schizophrenia; Diabetes Mellitus, Type 1; Cytokine Release Syndrome; Head and Neck Neoplasms; Ovarian Neoplasms; Bone Marrow Neoplasms Details
Pomalidomide IMID-4047; CDC-394; CC-4047; IMiD-1 Approved Celgene Corp Pomalyst, Imnovid, Actimid, Pomalyst/Imnovid, 安跃 Mainland China Multiple Myeloma Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2013-02-08 Pulmonary Fibrosis; Anemia, Sickle Cell; Atypical Squamous Cells of the Cervix; Neurofibromatosis 1; Sarcoma, Kaposi; Lymphoma, Non-Hodgkin; Carcinoma, Small Cell; Glioma; Waldenstrom Macroglobulinemia; Primary Myelofibrosis; Sarcoma; Prostatic Neoplasms; Thrombocytosis; Lung Diseases, Interstitial; Solid tumours; Central Nervous System Neoplasms; Multiple Myeloma; Hodgkin Disease; Scleroderma, Systemic; Pancreatic Neoplasms; Kidney Diseases; Immunoglobulin Light-chain Amyloidosis; Graft vs Host Disease; Myeloproliferative Disorders; Plasmacytoma; Polycythemia Vera; Medulloblastoma; Bone Marrow Neoplasms Details
Lenalidomide CC-5013; IMiD-3; ENMD-0997; STAR-LLD; CDC-501; IMID-5013; CDC-5013 Approved Celgene Corp Revimid (former Brand Name), 瑞复美, Revlimid, Leavdo EU Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular Celgene Europe Bv 2005-12-27 Leukemia; Leukemia, Myeloid; Immunoproliferative Small Intestinal Disease; Leukemia, Erythroblastic, Acute; Lymphoma, T-Cell, Peripheral; Lymphoma, B-Cell, Marginal Zone; Ovarian Neoplasms; Medulloblastoma; Intestinal Neoplasms; Bone Marrow Neoplasms; Solid tumours; Kidney Neoplasms; Liver Neoplasms; HIV Infections; Hematologic Diseases; Optic Nerve Glioma; Leukemia, Promyelocytic, Acute; Ependymoma; Anemia, Refractory, with Excess of Blasts; Plaque, Amyloid; Leukemia, Hairy Cell; Anemia; Paraproteinemias; Pain; Polycythemia Vera; Rhabdoid Tumor; Hodgkin Disease; Myelodysplastic Syndromes; Nerve Degeneration; Lymphomatoid Granulomatosis; Pancreatic Neoplasms; Smoldering Multiple Myeloma; Anemia, Refractory; Leukemia-Lymphoma, Adult T-Cell; Plasmacytoma; Lymphoma, Large B-Cell, Diffuse; Blood Protein Disorders; Neoplasms; Glioblastoma; Leukemia, Myelomonocytic, Chronic; Graft vs Host Disease; Hypothalamic Neoplasms; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Acute; Urinary Bladder Neoplasms; Multi Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 Osteosarcoma; Leprosy, Lepromatous; Drug Resistant Epilepsy; Primary Myelofibrosis; Neuroectodermal Tumors, Primitive; Prostatitis; Colorectal Neoplasms; Lymphoma, Mantle-Cell; Sarcoma, Ewing; Retinoblastoma; Waldenstrom Macroglobulinemia; Cholangitis, Sclerosing; HIV Wasting Syndrome; Arachnoiditis; Adenocarcinoma, Clear Cell; Prostatic Neoplasms; Pancreatitis, Chronic; Lymphoma, Follicular; Sarcoma; Xerostomia; Burning Mouth Syndrome; Neoplasm Metastasis; Mycobacterium avium-intracellulare Infection; Vascular Malformations; Amyotrophic Lateral Sclerosis; Melanoma; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Stomatitis; Erythema Nodosum; Anemia, Sideroblastic; Uterine Neoplasms; Lymphoma, Non-Hodgkin; Glioma; Angiodysplasia; Pelvic Pain; Appendiceal Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Mycobacterium Infections; Gastric Antral Vascular Ectasia; Carcinoid Tumor; Lupus Erythematosus, Discoid; Stomatitis, Aphthous; Rhabdomyosarcoma; Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-interleukin-6 receptor monoclonal antibody (Biocad) Phase 2 Clinical Biocad Autoimmune Diseases Details
Wogonin Phase 1 Clinical Shandong Buchang Pharmaceuticals Co Ltd, Hefei Cosource Medicine Technology, Daewoong Pharmaceutical Co Ltd, China Pharmaceutical University Respiratory Tract Infections; Neoplasms Details
Mycobacterium cell wall-DNA Complex (ProMetic Life Sciences) EN-3348 Prometic Life Sciences Details
MEDI-5117 WBP-216; MEDI-5117 Phase 1 Clinical Wuxi Apptec Co Ltd, Medimmune Arthritis, Rheumatoid Details
PF-04236921 PF-4236921; PF-04236921 Pfizer Pharmaceuticals Ltd (China) Details
Olokizumab CDP-6038; Anti-IL6-UCB Ucb Details
Ensereptide PXL-01 Phase 3 Clinical Promore Pharma Post-surgical adhesions; Cicatrix Details
FB-704A FB-704; FB-704A Phase 2 Clinical Fountain Biopharma Inc Arthritis, Rheumatoid; Asthma Details
Isomyosamine MYMD-1 Phase 2 Clinical Mymd Pharmaceuticals Inc Depression; Anxiety; Hashimoto Disease; Coronavirus Disease 2019 (COVID-19); Healthy Aging; Inflammation Details
Sirukumab BA-003; CNTO-136 Phase 2 Clinical Glaxosmithkline Plc, Janssen Global Services Llc Giant Cell Arteritis; Depressive Disorder, Major; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Lupus Erythematosus, Cutaneous; Lupus Nephritis; Polymyalgia Rheumatica; Lupus Erythematosus, Systemic; Asthma Details
Monoclonal Antibody (Mab) sB24M Phase 1 Clinical Swiss Biopharma Med GmbH Pyoderma Gangrenosum; Pyoderma Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc Leukemia; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Solid tumours; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details
Clazakizumab ALD-518; ALD518-003; BMS-645429; BMS-945429 Phase 3 Clinical Alder Biopharmaceuticals Plaque, Atherosclerotic; Arthritis, Rheumatoid; Fatigue; Coronavirus Disease 2019 (COVID-19); Graft vs Host Disease; Rejection of organ transplantation; Arthritis, Psoriatic; Asthma; Cachexia; Carcinoma, Non-Small-Cell Lung; Crohn Disease; Stomatitis; Kidney Failure, Chronic Details
RO-7200220 RO-7200220 Phase 2 Clinical F. Hoffmann-La Roche Ltd Diabetic macular oedema Details
Tocilizumab biosimilar (Mycenax Biotech) Phase 1 Clinical Mycenax Biotech Inc Arthritis, Rheumatoid Details
Ziltivekimab COR-001 Phase 3 Clinical Astrazeneca Pharmaceutical Co Ltd Heart Failure; Anemia; Cardiovascular Diseases; Renal Insufficiency, Chronic; Inflammation; Systemic Inflammatory Response Syndrome Details
Gerilimzumab GB-224; RYI-008; ARGX-109 Phase 1 Clinical Argenx Se Arthritis, Rheumatoid Details

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