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IL-6

IL-6 Molecule Information

Name:Interleukin-6
Target Synonym:B-cell stimulatory factor 2,Interferon beta-2,IL6,IFNB2,IL-6,Interleukin-6,Interleukin 6,Hybridoma Growth Factor,IFN-Beta-2,BSF-2,CDF,B-Cell Differentiation Factor,Interferon, Beta 2,Interleukin BSF-2,BSF2,HGF,HSF,CTL Differentiation Factor,Interleukin 6
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:18
Lastest Research Phase:Approved

IL-6 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IL6-M5245 Mouse Mouse IL-6 Protein, His Tag
IL6-M5245-structure
IL6-M5245-sds
IL6-M5245-elisa_1
IL6-H8218 Human Biotinylated Human IL-6 Protein, epitope tag free, ultra sensitivity (primary amine labeling)
IL6-H8218-structure
IL6-H8218-sds
IL6-H8218-elisa_1
IL6-H4218 Human ActiveMax® Human IL-6 Protein, Tag Free
IL6-H4218-structure
IL6-H4218-sds
IL6-H4218-elisa_1

IL-6 Part of Bioactivity data

IL6-H8218-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Human IL-6, epitope tag free, primary amine labeling (Cat. No. IL6-H8218) stimulates proliferation of TF-1 human erythroleukemic cell line. The EC50 for this effect is 0.2532-0.4489 ng/mL (Routinely tested).

IL6-H4218-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

ActiveMax® Human IL-6, Tag Free (Cat. No. IL6-H4218) stimulates proliferation of TF-1 human erythroleukemic cell line. The EC50 for this effect is 0.2856-0.3636 ng/mL (Routinely tested).

IL6-H8218-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human IL-6, epitope tag free, primary amine labeling (Cat. No. IL6-H8218) on SA Biosensor, can bind Human IL-6 R alpha, His Tag (Cat. No. ILR-H4223) with an affinity constant of 45.9 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL6-H4218-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-6 R alpha, Fc Tag (Cat. No. ILR-H5259) on Protein A Biosensor, can bind ActiveMax® Human IL-6, Tag Free(Cat. No. IL6-H4218) with an affinity constant of 35.9 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL-6 Molecule Synonym Name

IL6,Interleukin-6,BSF2,HSF,IFNB2

IL-6 Molecule Background

Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and  IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor  and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

IL-6 References

IL-6 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Thalidomide K-17; NSC-66847; NSC-527179 Approved Celgene Corp Thaled, Synovir, Talizer, Thalomid, Thalidomide Celgene, Thalidomide Pharmion Japan Leprosy, Lepromatous s:23:"Fujimoto Pharmaceutical"; 1982-01-01 HIV Infections; Spondylitis, Ankylosing; Myelodysplastic Syndromes; Multiple Myeloma; Erythema Nodosum; HIV Wasting Syndrome; Leprosy, Lepromatous; Carcinoma, Hepatocellular Details
Siltuximab cCLB-8; CNTO-328 Approved Eusa Pharma, Janssen Global Services Llc Sylvant EU Castleman Disease s:28:"Eusa Pharma (Netherlands) Bv"; 2014-04-23 Lung Diseases; Lymphoma, Non-Hodgkin; Lung Neoplasms; Castleman Disease; Colorectal Neoplasms; Neoplasms, Plasma Cell; Prostatic Neoplasms; Multicentric Castleman's Disease (MCD); Monoclonal Gammopathy of Undetermined Significance; Respiratory Distress Syndrome, Adult; Respiratory Tract Infections; Multiple Myeloma; Myelodysplastic Syndromes; Pancreatic Neoplasms; Smoldering Multiple Myeloma; Carcinoma, Renal Cell; Pneumonia; Ovarian Neoplasms; Head and Neck Neoplasms Details
Pomalidomide CDC-394; CC-4047; IMiD-1; IMID-4047 Approved Celgene Corp Pomalyst, Imnovid, Actimid, Pomalyst/Imnovid, 安跃 Mainland China Multiple Myeloma s:47:"Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd"; 2013-02-08 Central Nervous System Neoplasms; Anemia, Sickle Cell; Sarcoma, Kaposi; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasm Metastasis; Lymphoma, Non-Hodgkin; Primary Myelofibrosis; Lymphoma, Follicular; Prostatic Neoplasms; Sarcoma; Medulloblastoma; Lung Diseases, Interstitial; Multiple Myeloma; Lymphoma, Large B-Cell, Diffuse; Hodgkin Disease; Scleroderma, Systemic; Lymphoma, B-Cell; Bone Marrow Neoplasms; Solid tumours Details
Lenalidomide IMID-5013; CDC-5013; CDC-501; ENMD-0997; CC-5013; IMiD-3 Approved Celgene Corp 瑞复美, Revlimid, Revimid (former Brand Name) EU Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular s:17:"Celgene Europe Bv"; 2005-12-27 Lymphoma, Mantle-Cell; Carcinoma, Non-Small-Cell Lung; Crohn Disease; Complex Regional Pain Syndromes; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasm Metastasis; Melanoma; Waldenstrom Macroglobulinemia; Thrombocytopenia; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Lymphoma, Non-Hodgkin; Reflex Sympathetic Dystrophy; Radiculopathy; Lymphoma, Follicular; Prostatic Neoplasms; Lymphoma, B-Cell, Marginal Zone; Multiple Myeloma; Smoldering Multiple Myeloma; Blood Protein Disorders; Myelodysplastic Syndromes; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, Large B-Cell, Diffuse; Paraproteinemias; Anemia; Lymphoma, B-Cell; HIV Infections; Solid tumours; Hematologic Diseases; Lymphoma, T-Cell, Peripheral; Leukemia, Myeloid Details
Luminol sodium MP-1032 Approved Selvim, Metrio Psoriasis; Immune System Diseases s:4:"null"; 1997-01-01 Immune System Diseases; Psoriasis Details

IL-6 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PXL-01 PXL-01 Phase 3 Clinical Promore Pharma Tissue Adhesions; Post-surgical adhesions Details
EBI-031 EBI-031 Phase 1 Clinical Sesen Bio Diabetic macular oedema; Uveitis Details
FB-704A FB-704; FB-704A Phase 1 Clinical Fountain Biopharma Arthritis, Rheumatoid Details
Tocilizumab biosimilar (Mycenax Biotech) Phase 1 Clinical Mycenax Biotech Arthritis, Rheumatoid Details
Anti-interleukin-6 receptor monoclonal antibody (Biocad) Phase 2 Clinical Biocad Autoimmune Diseases Details
Gerilimzumab GB-224; RYI-008; ARGX-109 Phase 2 Clinical Argen-X Arthritis, Rheumatoid Details
Cis-urocanic acid Cis-UCA; UCA-001; UCA-002 Phase 2 Clinical Herantis Pharma Dry Eye Syndromes; Urinary Bladder Neoplasms; Xerophthalmia; Dermatitis, Atopic Details
DMT-210 DMT-200; DMT-210; DMT-220; SIG-990 Phase 2 Clinical Signum Dermalogix Rosacea; Dermatitis, Atopic Details
PF-04236921 PF-4236921; PF-04236921 Phase 2 Clinical Pfizer Pharmaceuticals Ltd (China) Arthritis, Rheumatoid; Lupus Erythematosus, Systemic; Crohn Disease Details
Olokizumab CDP-6038; Anti-IL6-UCB Phase 3 Clinical Ucb Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Arthritis; Crohn Disease Details
HL-2351 GX-P4; HL-2351; rhIL-1Ra-hyFc Phase 2 Clinical Genexine Inc Arthritis, Rheumatoid; Cryopyrin-Associated Periodic Syndromes Details
MEDI-5117 WBP-216; MEDI-5117 Phase 1 Clinical Wuxi Apptec Co Ltd, Medimmune Arthritis, Rheumatoid Details
Ziltivekimab COR-001 Phase 2 Clinical Astrazeneca Pharmaceutical Co Ltd Anemia; Renal Insufficiency, Chronic; Inflammation Details
Clazakizumab ALD-518; ALD518-003; BMS-645429; BMS-945429 Phase 3 Clinical Alder Biopharmaceuticals Anemia; Graft vs Host Disease; Fatigue; Arthritis, Rheumatoid; Rejection of organ transplantation; Arthritis, Psoriatic; Cachexia; Inflammation; Crohn Disease; Carcinoma, Non-Small-Cell Lung; Stomatitis Details
Wogonin Phase 1 Clinical Shandong Buchang Pharmaceuticals Co Ltd, Hefei Cosource Medicine Technology, Daewoong Pharmaceutical Co Ltd, China Pharmaceutical University Respiratory Tract Infections; Neoplasms Details
CD24-Fc HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110; CD24-Fc Phase 3 Clinical Oncoimmune HIV Infections; Leukemia; Coronavirus Disease 2019 (COVID-19); Graft vs Host Disease; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details

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