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Your Position: Home > IL-6

IL-6

Brief Information

Name:Interleukin-6
Target Synonym:CTL Differentiation Factor,Interleukin 6 (Interferon, Beta 2),HSF,B-cell stimulatory factor 2,Interferon beta-2,IL6,IFNB2,IL-6,Interleukin-6,Interleukin 6,Hybridoma Growth Factor,IFN-Beta-2,BSF-2,CDF,B-Cell Differentiation Factor,Interferon, Beta 2,Interleukin BSF-2,BSF2,HGF
Number of Launched Drugs:6
Number of Drugs in Clinical Trials:18
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
IL6-H5243 Human Human IL-6 Protein, His Tag (MALS verified)
IL6-H5243-structure
IL6-H5243-sds
GMP-L06H27 Human GMP Human IL-6 Protein
GMP-L06H27-structure
GMP-L06H27-sds
CRS-B001 Human ClinMax™ Human IL-6 ELISA Kit
EP-146 Human IL-6 [Biotinylated] : IL-6 R alpha Inhibitor Screening ELISA Kit
CRS-A005 Human resDetect™ Human Interleukin-6 (IL-6) ELISA Kit (Residue Testing)
IL6-C5249 Cynomolgus Cynomolgus IL-6 Protein, His Tag (MALS verified)
IL6-C5249-structure
IL6-C5249-sds
IL6-H82Q9 Human Biotinylated Human IL-6 Protein, Avitag™,His Tag (MALS verified)
IL6-H82Q9-structure
IL6-H82Q9-sds
IL6-M82Q7 Mouse Biotinylated Mouse IL-6 Protein, Avitag™,His Tag
IL6-M82Q7-structure
IL6-M82Q7-sds
IL6-M5245 Mouse Mouse IL-6 Protein, His Tag
IL6-M5245-structure
IL6-M5245-sds
IL6-H8218 Human Biotinylated Human IL-6 Protein, epitope tag free, ultra sensitivity, primary amine labeling
IL6-H8218-structure
IL6-H8218-sds
IL6-H4218 Human Human IL-6 Protein, premium grade
IL6-H4218-structure
IL6-H4218-sds
ACRO Quality

Part of Bioactivity data

GMP-L06H27-Cell-based assay
IL-6 CELL

GMP Human IL-6 Protein (Cat. No. GMP-L06H27) stimulates proliferation of TF-1 human erythroleukemic cell line. The specific activity of GMP Human IL-6 Protein is > 1.0ⅹ10^8 IU/mg, which is calibrated against human IL- 6 WHO International Standard (NIBSC code: 21/308) (QC tested).

Protocol
IL6-H8218-Cell-based assay
IL-6 CELL

Biotinylated Human IL-6, epitope tag free, primary amine labeling (Cat. No. IL6-H8218) stimulates proliferation of TF-1 human erythroleukemic cell line. The EC50 for this effect is 0.2532-0.4489 ng/mL (Routinely tested).

Protocol
IL6-H8218-BLI
IL-6 BLI

Loaded Biotinylated Human IL-6, epitope tag free, primary amine labeling (Cat. No. IL6-H8218) on SA Biosensor, can bind Human IL-6 R alpha, His Tag (Cat. No. ILR-H4223) with an affinity constant of 45.9 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
IL6-C5249-ELISA
IL-6 ELISA

Immobilized Cynomolgus IL-6, His Tag (Cat. No. IL6-C5249) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-6 R alpha, Fc,Avitag (Cat. No. ILR-H82F9) with a linear range of 0.6-39 ng/mL (QC tested).

Protocol

Synonym Name

IL6,Interleukin-6,BSF2,HSF,IFNB2

Background

Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and  IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor  and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Luminol sodium MP-1032 Approved Selvim, Metrio Immune System Diseases; Psoriasis null 1997-01-01 Coronavirus Disease 2019 (COVID-19); Immune System Diseases; Psoriasis Details
Andrographolide/Sodium Hydrogen Sulfite Approved Bacterial Infections Details
Pomalidomide IMID-4047; CDC-394; CC-4047; IMiD-1 Approved Celgene Corp Pomalyst, Imnovid, Actimid, Pomalyst/Imnovid, 安跃 United States Multiple Myeloma Bristol-Myers Squibb Company 2013-02-08 Pulmonary Fibrosis; Atypical Squamous Cells of the Cervix; Sarcoma, Kaposi; Anemia, Sickle Cell; Neurofibromatosis 1; Lymphoma, Non-Hodgkin; Carcinoma, Small Cell; Waldenstrom Macroglobulinemia; Glioma; Primary Myelofibrosis; Sarcoma; Thrombocytosis; Prostatic Neoplasms; Lung Diseases, Interstitial; Medulloblastoma; Central Nervous System Neoplasms; Multiple Myeloma; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Plasmacytoma; Kidney Diseases; Pancreatic Neoplasms; Myeloproliferative Disorders; Graft vs Host Disease; Scleroderma, Systemic; Polycythemia Vera; Bone Marrow Neoplasms; Solid tumours Details
Siltuximab cCLB-8; CNTO-328 Approved Johnson & Johnson Sylvant United States Multicentric Castleman's Disease (MCD) Janssen Biotech Inc 2014-04-23 Psychotic Disorders; Leukemia, Large Granular Lymphocytic; Lymphoma, Non-Hodgkin; Lung Neoplasms; Thrombocytopenia; Colorectal Neoplasms; Castleman Disease; Primary Myelofibrosis; Prostatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms, Plasma Cell; Multicentric Castleman's Disease (MCD); Lung Diseases; Monoclonal Gammopathy of Undetermined Significance; Respiratory Distress Syndrome, Adult; Multiple Myeloma; Bone Marrow Neoplasms; Immunoglobulin Light-chain Amyloidosis; Myelodysplastic Syndromes; Pancreatic Neoplasms; Smoldering Multiple Myeloma; Respiratory Tract Diseases; Schizophrenia; Pneumonia; Carcinoma, Renal Cell; Polycythemia Vera; Kidney Neoplasms; Respiratory Tract Infections; Cytokine Release Syndrome; Head and Neck Neoplasms; Ovarian Neoplasms; Diabetes Mellitus, Type 1 Details
Lenalidomide IMID-5013; CDC-5013; CDC-501; CC-5013; IMiD-3; ENMD-0997; STAR-LLD Approved Celgene Corp Revimid (former Brand Name), 瑞复美, Revlimid, Leavdo United States Myelodysplastic Syndromes Bristol Myers Squibb Srlcompany 2005-12-27 Lymphoma, B-Cell, Marginal Zone; Leukemia, Myeloid; Leukemia; Bone Marrow Neoplasms; Lymphoma, T-Cell, Peripheral; Solid tumours; Kidney Neoplasms; Hematologic Diseases; Medulloblastoma; Ovarian Neoplasms; Ependymoma; Optic Nerve Glioma; Intestinal Neoplasms; Immunoproliferative Small Intestinal Disease; Leukemia, Erythroblastic, Acute; Leukemia, Promyelocytic, Acute; Liver Neoplasms; HIV Infections; Anemia; Pain; Paraproteinemias; Polycythemia Vera; Plaque, Amyloid; Rhabdoid Tumor; Leukemia, Hairy Cell; Anemia, Refractory, with Excess of Blasts; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Neoplasms; Leukemia, Myelomonocytic, Chronic; Graft vs Host Disease; Hodgkin Disease; Glioblastoma; Leukemia-Lymphoma, Adult T-Cell; Plasmacytoma; Blood Protein Disorders; Nerve Degeneration; Pancreatic Neoplasms; Anemia, Refractory; Hypothalamic Neoplasms; Lymphomatoid Granulomatosis; Smoldering Multiple Myeloma; Leukemia, Myelomonocytic, Acute; Multiple Myeloma; Urinary Bladder Neoplasms; Central Nervous S Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02; FPF-300; FPF300 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Mainland China Leprosy, Lepromatous; Multiple Myeloma Changzhou Pharmaceutical Factory 1982-01-01 Lymphoma, Mantle-Cell; Leprosy, Lepromatous; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Prostatitis; Primary Myelofibrosis; Adenocarcinoma, Clear Cell; Lymphoma, Follicular; Carcinoma, Adenosquamous; Cholangitis, Sclerosing; Osteosarcoma; Endometrial Neoplasms; Xerostomia; Gastrointestinal Hemorrhage; Sarcoma, Ewing; HIV Wasting Syndrome; Pancreatitis, Chronic; Arachnoiditis; Retinoblastoma; Erythema Nodosum; Prostatic Neoplasms; Drug Resistant Epilepsy; Leukemia, Lymphocytic, Chronic, B-Cell; Vascular Malformations; Myelodysplastic-Myeloproliferative Diseases; Stomatitis; Burning Mouth Syndrome; Mycobacterium avium-intracellulare Infection; Amyotrophic Lateral Sclerosis; Neoplasm Metastasis; Carcinoma, Hepatocellular; Melanoma; Sarcoma; Angiodysplasia; Lymphoma, Non-Hodgkin; Appendiceal Neoplasms; Pelvic Pain; Waldenstrom Macroglobulinemia; Glioma; Uterine Neoplasms; Anemia, Sideroblastic; Lung Neoplasms; Mycobacterium Infections; Lupus Erythematosus, Discoid; Anemia, Refractory, with Excess of Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
MEDI-5117 WBP-216; MEDI-5117 Phase 1 Clinical Wuxi Apptec Co Ltd, Medimmune Arthritis, Rheumatoid Details
Isomyosamine MYMD-1 Phase 2 Clinical Mymd Pharmaceuticals Inc Depression; Anxiety; Hashimoto Disease; Frailty; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Healthy Aging; Inflammation; Sarcopenia Details
KSI-501 KSI-501 Phase 1 Clinical Kodiak Sciences Inc Diabetic macular oedema; Uveitis Details
FB-704A FB-704; FB-704A Phase 2 Clinical Fountain Biopharma Inc Arthritis, Rheumatoid; Asthma Details
Tocilizumab biosimilar (Mycenax Biotech) Phase 1 Clinical Mycenax Biotech Inc Arthritis, Rheumatoid Details
NEX-20A NEX-20A Phase 1 Clinical Nanexa AB Multiple Myeloma Details
Ensereptide PXL-01 Phase 3 Clinical Promore Pharma Post-surgical adhesions; Tissue Adhesions; Cicatrix Details
Anti-interleukin-6 receptor monoclonal antibody (Biocad) Phase 2 Clinical Biocad Autoimmune Diseases Details
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 Phase 3 Clinical Oncoimmune Inc Solid tumours; Hematopoietic stem cell transplantation (HSCT); Leukemia; HIV Infections; Graft vs Host Disease; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma Details
PF-04236921 PF-4236921; PF-04236921; TOUR006; TOUR-006 Phase 2 Clinical Pfizer Pharmaceuticals Ltd (China) Arthritis, Rheumatoid; Graves Ophthalmopathy; Lupus Erythematosus, Systemic; Crohn Disease Details
RG-6179 RG-6179 Phase 1 Clinical F. Hoffmann-La Roche Ltd Diabetic macular oedema Details
Ziltivekimab COR-001 Phase 3 Clinical Astrazeneca Plc Myocardial Infarction; Heart Failure; Anemia; Cardiovascular Diseases; Renal Insufficiency, Chronic; Inflammation; Systemic Inflammatory Response Syndrome Details
RO-7200220 RO-7200220 Phase 3 Clinical F. Hoffmann-La Roche Ltd Macular Edema; Diabetic macular oedema Details
Gerilimzumab GB-224; RYI-008; ARGX-109 Phase 1 Clinical Argenx Se Arthritis, Rheumatoid Details
Olokizumab CDP-6038; Anti-IL6-UCB Phase 3 Clinical Ucb Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Arthritis; Crohn Disease Details
Clazakizumab ALD-518; ALD518-003; BMS-645429; BMS-945429 Phase 3 Clinical Alder Biopharmaceuticals Plaque, Atherosclerotic; Arthritis, Rheumatoid; Fatigue; Coronavirus Disease 2019 (COVID-19); Graft vs Host Disease; Rejection of organ transplantation; Arthritis, Psoriatic; Asthma; Cachexia; Crohn Disease; Carcinoma, Non-Small-Cell Lung; Stomatitis; Kidney Failure, Chronic Details
Sirukumab BA-003; CNTO-136 Phase 2 Clinical Glaxosmithkline Plc Giant Cell Arteritis; Depressive Disorder, Major; Arthritis, Rheumatoid; Lupus Erythematosus, Cutaneous; Coronavirus Disease 2019 (COVID-19); Lupus Nephritis; Polymyalgia Rheumatica; Lupus Erythematosus, Systemic; Asthma Details
Wogonin Shandong Buchang Pharmaceuticals Co Ltd, Hefei Cosource Medicine Technology, Daewoong Pharmaceutical Co Ltd, China Pharmaceutical University Details

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