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Your Position: Home > SLAMF7

SLAMF7

SLAMF7 Molecule Information

Name:SLAM family member 7
Target Synonym:Novel Ly9;CS1;CD_antigen=CD319;Membrane protein FOAP-12;CRACC;SLAMF7;Protein 19A;SLAM family member 7;CD2 subset 1;CD2-like receptor-activating cytotoxic cells

Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

SLAMF7 Protein Product ListCompare or Buy

Product> Filter Results

Cat. No.	Species	Product Description
SL7-HP2H3	Human	PE-Labeled Human SLAMF7 / CRACC / CD319 Protein, His Tag
SL7-HF2H7	Human	FITC-Labeled Human SLAMF7 / CRACC / CD319 Protein, His Tag
SL7-R52H7	Rhesus macaque	Rhesus macaque SLAMF7 / CRACC / CD319 Protein, His Tag
SL7-M5252	Mouse	Mouse SLAMF7 / CRACC / CD319 Protein, Mouse IgG2a Fc Tag, low endotoxin
SL7-H82E0	Human	Biotinylated Human SLAMF7 / CRACC / CD319 Protein, Avitag™,His Tag
SL7-H5256	Human	Human SLAMF7 / CRACC / CD319 Protein, Fc Tag
SL7-H5225	Human	Human SLAMF7 / CRACC / CD319 Protein, His Tag

SLAMF7 Part of Bioactivity data

SL7-HP2H3-Cell-based assay

FACS assay shows that recombinant Biotinylated FACS

1e6 of the anti-SLAMF7 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human SLAMF7, His Tag (Cat. No. SL7-HP2H3) and negative control protein respectively, PE signals was used to evaluate the binding activity (QC tested).

Protocol

SL7-HF2H7-Cell-based assay

2e5 of Anti-SLAMF7 CAR-293 cells were stained with 100 μL of 10 μg/mL of FITC-Labeled Human SLAMF7, His Tag (Cat. No. SL7-HF2H7) and negative control protein respectively, FITC signal was used to evaluate the binding activity (QC tested)

Protocol

SL7-H5256-ELISA

Immobilized Human SLAMF7, Fc Tag (Cat. No. SL7-H5256) at 2 μg/mL (100 μL/well) can bind Humanized Anti-Human CS1 MAb with a linear range of 0.3-5 ng/mL (Routinely tested).

Protocol

SL7-H82E0-ELISA

Immobilized Humanized Anti-Human CS1 MAb at 1 μg/mL (100 μL/well) can bind Biotinylated Human SLAMF7, Avitag,His Tag (Cat. No. SL7-H82E0) with a linear range of 0.6-5 ng/mL (Routinely tested).

Protocol

SLAMF7 Molecule Synonym Name

SLAMF7,CD319,CS1,CRACC,19A,FOAP-12

SLAMF7 Molecule Background

SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.

SLAMF7 References

SLAMF7 Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Elotuzumab	HuLuc-63; BMS-901608; PDL-063	Approved	Abbvie, Bristol-Myers Squibb	EMPLICITI	fda	Multiple myeloma (MM)	BRISTOL MYERS SQUIBB	2015-11-30	Multiple myeloma (MM)	Details

SLAMF7 Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
UCART-CS1	UCART-CS1; UCART-38	Phase Ⅰ	Cellectis, M.D. Anderson Cancer Center	Multiple myeloma (MM)	Details
BCMA-CS1 cCAR T cell therapy (iCell Gene Therapeutics)		Phase Ⅰ	iCell Gene Therapeutics	Multiple myeloma (MM)	Details
Azintuxizumab vedotin	ABBV-838	Phase Ⅰ	Abbvie	Multiple myeloma (MM)	Details
CD319 chimeric antigen T cell therapy (Wuhan Bio Raid Biotechnology)		Phase Not Specified	Wuhan Bio-Raid Biotechnology, Tongji Hospital	hematological malignancies	Details