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TIM-3

Licensing

Project item Indications Research phase Cooperation demands
BMS21010 Tumors such as lung cancer,liver cancer, gastric carcinoma, cervical cancer, prostate cancer. cell line screening Project authorization, transfer or co-development. (project’s company is seeking for external cooperation to accelate drug research and development.)

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Part of Bioactivity data

TM3-H5258-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human TIM-3, Fc Tag (Cat. No. TM3-H5258) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human Galectin-9, His Tag (Cat. No. LG9-H5244) with an affinity constant of 57 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

TM3-H5229-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-Human TIM-3 MAb (human IgG4) captured on CM5 chip via Anti-Human IgG Fc antibodies surface, can bind Human TIM-3, His Tag (Cat. No. TM3-H5229) with an affinity constant of 9.7 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

HAVCR2,TIM3,TIMD3,FLJ14428,KIM3

Background

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428,  KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

Clinical and Translational Updates

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