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TIM-3

TIM-3 Molecule Information

Name:Hepatitis A virus cellular receptor 2
Target Synonym:TIM-3?T-cell immunoglobulin and mucin domain-containing protein 3?TIMD3?HAVcr-2?TIMD-3?T-cell membrane protein 3?T-cell immunoglobulin mucin receptor 3?TIM3?HAVCR2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase ?

TIM-3 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
TM3-H525b Human Human TIM-3 / HAVCR2 Protein, Mouse IgG2a Fc Tag, low endotoxin
TM3-H525b-structure
TM3-H525b-sds
TM3-H525b-elisa_1
TI3-C52H4 Cynomolgus Cynomolgus TIM-3 / HAVCR2 Protein
TI3-C52H4-structure
TI3-C52H4-sds
TI3-C52H4-elisa_1
TM3-H82E7 Human Biotinylated Human TIM-3 / HAVCR2 Protein, His Tag & Avi Tag (Avitag™)
TM3-H82E7-structure
TM3-H82E7-sds
TM3-H82E7-elisa_1
TI3-C525b Cynomolgus Cynomolgus TIM-3 / HAVCR2 Protein, Fc Tag
TI3-C525b-structure
TI3-C525b-sds
TI3-C525b-elisa_1
TI3-H5285 Human Human TIM-3 / HAVCR2 (22-200) Protein, Strep Tag
TI3-H5285-structure
TI3-H5285-sds
TI3-H5285-elisa_1
TI3-M52H1 Mouse Mouse TIM-3 / HAVCR2 Protein
TI3-M52H1-structure
TI3-M52H1-sds
TI3-M5252 Mouse Mouse TIM-3 / HAVCR2 Protein, Fc Tag
TI3-M5252-structure
TI3-M5252-sds
TM3-H5258 Human Human TIM-3 / HAVCR2 (22-200) Protein, Fc Tag
TM3-H5258-structure
TM3-H5258-sds
TM3-H5258-elisa_1
TM3-H5229 Human Human TIM-3 / HAVCR2 Protein
TM3-H5229-structure
TM3-H5229-sds
TM3-H5229-elisa_1
TM3-H5229-elisa_2
KI3-H5252 Human Human TIM-3 / HAVCR2 (22-142) Protein, Fc Tag
KI3-H5252-structure
KI3-H5252-sds
KI3-H5252-elisa_1

TIM-3 Molecule Synonym Name

HAVCR2,TIM3,TIMD3,FLJ14428,KIM3

TIM-3 Molecule Background

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428,  KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

TIM-3 References

TIM-3 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
INCAGN-02390 INCAGN-02390 Phase Ⅰ Agenus, Incyte Cancer Details
BMS-986258 BMS-986258; ONO-7807 Phase Ⅱ Bristol-Myers Squibb, Five Prime Therapeutics, Ono Pharmaceutical Solid tumours Details
Cobolimab TSR-022 Phase Ⅰ AnaptysBio, Tesaro Solid tumours Details
CA-327 CA-327; AUPM-327 Preclinical Aurigene, Curis Cancer Details
LY-3321367 LY-3321367 Phase Ⅰ Lilly Solid tumours Details
RO-7121661 Phase Ⅰ Roche Non small cell lung cancer (NSCLC), Solid tumours, Melanoma Details
MBG-453 MBG-453 Phase Ⅱ Novartis Solid tumours Details
Sym-023 Sym-023 Phase Ⅰ Symphogen Solid tumours, Lymphoma Details

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