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Your Position: Home > IL-8

IL-8

Brief Information

Name:Interleukin-8
Target Synonym:IL8/NAP1 form VI,T-cell chemotactic factor,GCP/IL-8 protein III,IL8/NAP1 form II,GCP/IL-8 protein II,(Ala-IL-8)77,Emoctakin,IL8/NAP1 form IV,LYNAP,IL8/NAP1 form III,IL8/NAP1 form V,GCP/IL-8 protein I,Neutrophil-Activating Peptide 1,Interleukin 8,GCP-1,MDNCF,NAP-1,IL8,Beta Endothelial Cell-Derived Neutrophil Activating Peptide,Lung Giant Cell Carcinoma-Derived Chemotactic Protein,Lymphocyte Derived Neutrophil Activating Peptide,Alveolar Macrophage Chemotactic Factor I,Tumor Necrosis Factor-Induce
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
IL8-H5217 Human Human IL-8 / CXCL8 Protein, premium grade
IL8-H5217-structure
IL8-H5217-sds
IL8-H5217-hplc
CRS-B004 Human ClinMax™ Human IL-8 ELISA Kit
IL8-C52H4 Rhesus macaque Rhesus macaque IL-8 / CXCL8 Protein, His Tag (MALS verified)
IL8-C52H4-structure
IL8-C52H4-sds
CEA-C004 Human ClinMax™ Human IL-8 ELISA Kit, PRO
IL8-H82H3 Human Biotinylated Human IL-8 protein, His,Avitag™
IL8-H82H3-structure
IL8-H82H3-sds
IL8-H5258 Human Human IL-8 / CXCL8 Protein, Fc Tag
IL8-H5258-structure
IL8-H5258-sds
IL8-H52H3 Human Human IL-8 / CXCL8 Protein, His Tag, premium grade
IL8-H52H3-structure
IL8-H52H3-sds
ACRO Quality

Part of Bioactivity data

IL8-C52H4-ELISA
IL-8 ELISA

Immobilized Rhesus macaque IL-8 / CXCL8 Protein, His Tag (Cat. No. IL8-C52H4) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human IL-8 Antibody, Human IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

Protocol
IL8-C52H4-MALS-HPLC
IL-8 MALS images

The purity of Rhesus macaque IL-8 Protein, His Tag (Cat. No. IL8-C52H4) is more than 85% and the molecular weight of this protein is around 14-20 kDa verified by SEC-MALS.

Synonym Name

CXCL8,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1

Background

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Mouse monoclonal antibody against human interleukin-8 cream Approved Dalian Asia Space Pharmaceutical Co Ltd, Dongguan Hongyuan Yishi Biotechnology Pharmaceutical Co Ltd 恩博克 Mainland China Eczema; Psoriasis Dalian Asia Space Pharmaceutical Co Ltd 2001-04-10 Psoriasis; Eczema Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AC-701 AC-701 Phase 2 Clinical Twi Pharmaceuticals Inc Rosacea; Exanthema Details
Ensereptide PXL-01 Phase 3 Clinical Promore Pharma Post-surgical adhesions; Tissue Adhesions; Cicatrix Details
AMY-109 AMY-109; AMY109 Phase 2 Clinical Chugai Pharmaceutical Co Ltd Solid tumours; Endometriosis Details
HuMax-IL8 MDX-018; BMS-986253 Phase 2 Clinical Medarex, Genmab A/S, Bristol-Myers Squibb Company Hematologic Neoplasms; Solid tumours; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular Details

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