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IL-8

IL-8 Molecule Information

Name:Interleukin-8
Target Synonym:Granulocyte chemotactic protein 1;Monocyte-derived neutrophil-activating peptide;IL-8(1-77);IL-8(9-77);Monocyte-derived neutrophil chemotactic factor;IL-8(7-77);(Ser-IL-8)72;GCP/IL-8 protein V;MONAP;C-X-C motif chemokine 8;GCP/IL-8 protein I;Neutrophil-ac
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

IL-8 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IL8-C52H3 Cynomolgus Cynomolgus IL-8 / CXCL8 Protein, His Tag
IL8-C52H3-structure
IL8-C52H3-sds
IL8-C52H3-elisa_1
IL8-H5258 Human Human IL-8 / CXCL8 Protein, Fc Tag
IL8-H5258-structure
IL8-H5258-sds
IL8-H5258-elisa_1
IL8-H52H3 Human Human IL-8 / CXCL8 Protein, His Tag
IL8-H52H3-structure
IL8-H52H3-sds
IL8-H52H3-elisa_1

IL-8 Part of Bioactivity data

IL8-H5258-ELISA
Human IL-8, Fc TagHuman IL-8, Fc Tag (Cat. No. IL8-H5258) ELISA bioactivity

Immobilized Human IL-8, Fc Tag (Cat. No. IL8-H5258) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human IL-8 Antibody, Human IgG1 with a linear range of 0.2-4 ng/mL (QC tested).

IL8-C52H3-ELISA
Cynomolgus IL-8, His TagCynomolgus IL-8, His Tag (Cat. No. IL8-C52H3) ELISA bioactivity

Immobilized Cynomolgus IL-8, His Tag (Cat. No. IL8-C52H3) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human IL-8 Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

IL-8 Molecule Synonym Name

CXCL8,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1

IL-8 Molecule Background

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

IL-8 References

IL-8 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Mouse monoclonal antibody against human interleukin-8 cream Approved Asia Space Pharmaceutical, Dongguan Hongyuan Yishi Biotechnology Pharmaceutical Mouse Monoclonal Antibody against Human Interleukin-8 Cream cfda Psoriasis vulgaris, Eczema 2015-08-28 Psoriasis vulgaris, Eczema Details

IL-8 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CXCR1/2 ligands antibody Phase Ⅰ Lilly Immunological disorders Details
AC-701 AC-701 Phase Ⅱ TWi Pharma Exanthema, Facial Erythema of Rosacea Details
ABX-IL8 ABX-IL8 Phase Ⅱ Xenotech, Japan Tobacco, Abgenix, Amgen Psoriasis, Rheumatoid arthritis (RA), Inflammatory bowel disease, Chronic obstructive pulmonary disease (COPD), Melanoma Details
HuMax-IL8 BMS-986253; MDX-018 Phase Ⅱ Genmab, Medarex, Bristol-Myers Squibb Non small cell lung cancer (NSCLC), Liver cancer Details
Binetrakin Sch-39400 Phase Ⅱ Merck Sharp & Dohme, Nonindustrial source Non small cell lung cancer (NSCLC), Gastrointestinal cancer, Solid tumours, Inflammation, Acute lymphoblastic leukaemia (ALL), Rheumatoid arthritis (RA), Immunodeficiency disorders Details
GRO beta MGTA-145 Phase Ⅰ Magenta Therapeutics Stem cell mobilization Details
SRX-01 SRX-01 Phase Ⅱ SatRx Metabolic disorders Details
IL-8 receptor (Repligen) Phase Not Specified Repligen Psoriasis, Systemic lupus erythematosus, Shock, Rheumatoid arthritis (RA), Asthma, Inflammatory bowel disease Details
ABT-325 (Abbott) ABT-325; MAb 2.5(E)mg1 Phase Ⅰ Abbott Autoimmune diseases Details
KOB-03 KOB-03 Phase Ⅱ Dong Wha Pharmaceuticals Allergic rhinitis (AR) Details
HL-2351 HL-2351; GX-P4; rhIL-1Ra-hyFc Phase Ⅱ Genexine, Handok Inc Rheumatic disorders, Cryopyrin-Associated Periodic Syndromes (CAPS) Details
Cis-urocanic acid UCA-001; UCA-002; Cis-UCA Phase Ⅱ Herantis Pharma Atopic dermatitis, Dry eye disease Details
PXL-01 PXL-01 Phase Ⅲ ProMore Pharma, Technomark Life Sciences, PharmaResearch Products Post-surgical adhesions Details

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