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Fc gamma RIIIA / CD16a

Fc gamma RIIIA / CD16a Protein Product ListCompare or Buy

Fc gamma RIIIA / CD16a Part of Bioactivity data

CDA-H82E9-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human CD16a (V176), Avitag,His Tag (SPR & BLI verified) (Cat. No. CDA-H82E9) captured on Biotin CAP- Series S Sensor Chip can bind Rituximab with an affinity constant of 0.261 μM as determined in a SPR assay (Biacore T200) (QC tested).

CDA-H82E9-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Biotinylated Human CD16a (V176), Avitag,His Tag (SPR & BLI verified) (Cat. No. CDA-H82E9) on SA Chip can bind Rituximab with an affinity constant of 0.3 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Fc gamma RIIIA / CD16a Customer Reviews

Fc gamma RIIIA / CD16a Molecule Synonym Name

FCGR3A,CD16A,FCG3,FCGR3,IGFR3

Fc gamma RIIIA / CD16a Molecule Background

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed  natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody­dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

Fc gamma RIIIA / CD16a References

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