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Your Position: Home > Fc gamma RIIIA / CD16a

Fc gamma RIIIA / CD16a

Brief Information

Name:Low affinity immunoglobulin gamma Fc region receptor III-A
Target Synonym:Low affinity immunoglobulin gamma Fc region receptor III-A,FCGR3,CD16A,Fc-gamma RIII-alpha,FCGR3A,Fc Fragment Of IgG Receptor IIIa,Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a),CD16a Antigen,IGFR3,FCG3,Fc Fragment Of IgG, Low Affinity IIIa, Rece
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

CDA-H82E9-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human CD16a (V176), Avitag,His Tag (SPR & BLI verified) (Cat. No. CDA-H82E9) captured on Biotin CAP- Series S Sensor Chip can bind Rituximab with an affinity constant of 0.261 μM as determined in a SPR assay (Biacore T200) (QC tested).

CDA-H82E9-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Biotinylated Human CD16a (V176), Avitag,His Tag (SPR & BLI verified) (Cat. No. CDA-H82E9) on SA Chip can bind Rituximab with an affinity constant of 0.3 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Customer Reviews

Synonym Name

FCGR3A,CD16A,FCG3,FCGR3,IGFR3

Background

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed  natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody­dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AFM-24 AFM-24 Phase 2 Clinical Affimed Neoplasms Details
OXS-3550 OXS-3550-TriKE; GTB-3550; OXS-3550; OXIS-3550; 161533-TriKE; 161533 TriKE Phase 2 Clinical University Of Minnesota, Oxis Biotech Mastocytosis, Systemic; Myelodysplastic Syndromes; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute Details
AFM-13 AFM-13 Phase 2 Clinical The University Of Texas MD Anderson Cancer Center Lymphoma, T-Cell, Peripheral; Hodgkin Disease; Mycosis Fungoides Details

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