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Your Position: Home > ICOS

ICOS

Brief Information

Name:Inducible T-cell costimulator
Target Synonym:Activation-inducible lymphocyte immunomediatory molecule,Inducible T-cell costimulator,ICOS,CD278,AILIM,Inducible T Cell Costimulator,Inducible T-Cell Co-Stimulator,Inducible Costimulator,CD278 Antigen,CVID1,Inducible T-Cell Co-Stimulator Protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ICS-R52H9 Rat Rat ICOS / CD278 (C137S, C138S) Protein, His Tag
ICS-R52H9-structure
ICS-R52H9-sds
ICS-H52H9 Human Human ICOS / CD278 (C136S, C137S) Protein, His Tag (MALS verified)
ICS-H52H9-structure
ICS-H52H9-sds
ICS-M5259 Mouse Mouse ICOS / CD278 (C137S, C138S) Protein, Fc Tag
ICS-M5259-structure
ICS-M5259-sds
ICS-M52H8 Mouse Mouse ICOS / CD278 (C137S, C138S) Protein, His Tag
ICS-M52H8-structure
ICS-M52H8-sds
ICS-H5258 Human Human ICOS / CD278 Protein, Fc Tag
ICS-H5258-structure
ICS-H5258-sds
ICS-H82E5 Human Biotinylated Human ICOS / CD278 (C136S, C137S) Protein, His,Avitag™ (recommended for biopanning)
ICS-H82E5-structure
ICS-H82E5-sds
ACRO Quality

Part of Bioactivity data

ICS-H52H9-ELISA
Human ICOS (C136S, C137S), His TagHuman ICOS (C136S, C137S), His Tag (Cat. No. ICS-H52H9) ELISA bioactivity

Immobilized Human B7-H2, Fc Tag (Cat. No. B72-H5254) at 1 μg/mL (100 μL/well) can bind Human ICOS (C136S, C137S), His Tag (Cat. No. ICS-H52H9) with a linear range of 0.02-0.313 μg/mL (QC tested).

Protocol
ICS-H52H9-MALS-HPLC
Human ICOS (C136S, C137S), His Tag (Cat. No. ) MALS images

The purity of Human ICOS (C136S, C137S), His Tag (Cat. No. ICS-H52H9) is more than 90% and the molecular weight of this protein is around 19-29 kDa verified by SEC-MALS.

Report
Bioactivity-ELISA
Human ICOS (C136S, C137S), His TagHuman ICOS (C136S, C137S), His Tag (Cat. No. ICS-H52H9) ELISA bioactivity

Immobilized Human B7-H2, Fc Tag (Cat. No. B72-H5254) at 1 μg/mL (100 μL/well) can bind Human ICOS (C136S, C137S), His Tag (Cat. No. ICS-H52H9) with a linear range of 0.02-0.313 μg/mL (QC tested).

Synonym Name

ICOS,CD278,AILIM,Inducible T-cell costimulator

Background

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Clinical and Translational Updates

Related Molecule

B7-H2

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-ICOS (Bristol Myers Squibb) BMS-986226 Phase 1 Clinical Neoplasms Details
MEDI-570 Phase 1 Clinical Japan Tobacco (Hong Kong) Ltd Lymphoma, Follicular; Lupus Erythematosus, Systemic; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, Non-Hodgkin; Mycosis Fungoides Details
Vopratelimab JTX-2011 Phase 2 Clinical Jounce Therapeutics Inc Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Alomfilimab KY-1044 Phase 2 Clinical Kymab Ltd Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Esophageal Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Pancreatic Neoplasms; Melanoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Neoplasm Metastasis Details
Feladilimab GSK-609; GSK-3359609 Phase 3 Clinical Glaxosmithkline Plc Head and Neck Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Multiple Myeloma Details
Izuralimab XmAb-23104; XmAb-104 Phase 1 Clinical Xencor Inc Nasopharyngeal Carcinoma; Uterine Cervical Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Endometrial Neoplasms; Colorectal Neoplasms; Sarcoma; Breast Neoplasms; Solid tumours; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Stomach Neoplasms Details
Acazicolcept ALPN-101 Phase 2 Clinical Alpine Immune Sciences Inc, Abbvie Inc Graft vs Host Disease; Autoimmune Diseases; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Inflammation Details

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