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Your Position: Home > CD7

CD7

Brief Information

Name:T-cell antigen CD7
Target Synonym:T-cell antigen CD7,GP40,CD7,TP41,CD7 Molecule,T-Cell Leukemia Antigen,T-Cell Surface Antigen Leu-9,CD7 Antigen (P41),P41 Protein,CD7 Antigen,LEU-9,Tp40,Antigens, CD7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

CD7-HP2E3-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-CD7 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human CD7 Protein, His Tag(Cat. No. CD7-HP2E3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

CD7-H82F3-ELISA
Biotinylated Human CD7, Fc,AvitagBiotinylated Human CD7, Fc,Avitag (Cat. No. CD7-H82F3) ELISA bioactivity

Immobilized Biotinylated Human CD7, Fc,Avitag (Cat. No. CD7-H82F3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-CD7 antibody, Mouse IgG1 with a linear range of 1-2 ng/mL (QC tested).

CD7-H82F3-MALS-HPLC
Biotinylated Human CD7, Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human CD7, Fc,Avitag(Cat. No. CD7-H82F3) is more than 90% and the molecular weight of this protein is around 95-115 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Human CD7, Fc,AvitagBiotinylated Human CD7, Fc,Avitag (Cat. No. CD7-H82F3) ELISA bioactivity

Immobilized Biotinylated Human CD7, Fc,Avitag (Cat. No. CD7-H82F3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-CD7 antibody, Mouse IgG1 with a linear range of 1-2 ng/mL (QC tested).

Synonym Name

CD7,GP40,TP41,LEU-9,Tp40

Background

T-cell antigen CD7 (CD7) is also known as GP40, LEU-9, TP41 and Tp40. CD7 is a protein that in humans is encoded by the CD7 gene, this gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. CD7 has been shown to interact with PIK3R1. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CD7 targeted CAR-γδ T Cells (Persongen Bio) Phase 1 Clinical Leukemia, B-Cell Details
GC-027 GC-027 Phase 1 Clinical Gracell Biotechnologies (Shanghai) Co Ltd Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
CD7 CARvac T cell therapy Icell Gene Therapeutics Details
CTD-401 CTD-401; CTD401 Clinical Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
Anti-CD7 universal CAR-T cell therapy (Xinqiao Hospital) Phase 1 Clinical Xinqiao Hospital, Army Medical University Lymphoma, T-Cell; Leukemia, T-Cell Details
CD7-CAR-T cell therapy (PersonGen Biomedicine) Phase 1 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd, The First Affiliated Hospital Of Zhengzhou University Enteropathy-Associated T-Cell Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell Details
SenL-T7 CAR T Cells (Hebei Senlang Biological) Details
CAR7-T Cell Therapy (Beijing Gaobo Biotechnology Co Ltd) Phase 1 Clinical Lymphoma, T-Cell; Leukemia, T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell Details
Humanized CD7 CAR-T cells Phase 2 Clinical The First Affiliated Hospital Of Soochow University Lymphoma, T-Cell Details
RD13-01 RD13-01 Clinical Zhejiang University Hematologic Neoplasms Details
Anti-Cd7 chimeric antigen receptor natural killer cell therapy (PersonGen Biomedicine) Phase 2 Clinical Persongen Biotherapeutics (Suzhou) Co Ltd Leukemia; Lymphoma, T-Cell, Peripheral; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Extranodal NK-T-Cell; Leukemia, Prolymphocytic, T-Cell; Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Leukemia, Large Granular Lymphocytic Details
Anti-CD7 and anti-CD19 chimeric antigen receptor T cell therapy GC-197 Phase 2 Clinical Gracell Biotechnologies (Shanghai) Co Ltd Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Details
Anti-CD3 ricin chain A conjugate/anti-CD7 ricin chain A conjugate HENO-3; SPV-T3a Phase 3 Clinical Xenikos Graft vs Host Disease Details
PA3-17 PA3-17; PA-3-17 Phase 1 Clinical Persongen Anke Cell Technology Co Ltd, Persongen Biotherapeutics (Suzhou) Co Ltd Hematologic Neoplasms; Lymphoma Details
This CAR-T-7 cells therapy This CAR-T-7 cells Phase 1 Clinical Fundamenta Therapeutics Ltd Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell Details
Anti-CD7 CAR T-cell therapy (Yake Biotechnology) Phase 2 Clinical Shanghai YaKe Biotechnology Co Ltd Leukemia; Lymphoma Details

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