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Fc gamma RIIA / CD32a

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Fc gamma RIIA / CD32a Molecule Synonym Name

CD32a,FCGR2A,CD32,FCG2 ,FCGR2A1,IGFR2

Fc gamma RIIA / CD32a Molecule Background

Receptors for the Fc region of IgG (Fc ? R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc ? Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fc? RII /CD32 (A, B, and C) and one for mouse Fc? RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIM­bearing receptors may also be coexpressed and co­engaged by specific ligands. CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

Fc gamma RIIA / CD32a References

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