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Your Position: Home > Fc gamma RIIA / CD32a

Fc gamma RIIA / CD32a

Brief Information

Name:Low affinity immunoglobulin gamma Fc region receptor II-a
Target Synonym:Fc Gamma Receptor RIIa3,IgG Fc receptor II-a,CDw32,Fc-gamma-RIIa,Low affinity immunoglobulin gamma Fc region receptor II-a,FCGR2A1,Fc-gamma RII-a,CD32,FCGR2A,Fc Fragment Of IgG Receptor IIa,Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32),Immunoglobu
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Part of Bioactivity data

CDA-R52H5-SPR
Human_FcRn_Heterodimer_Protein_SPR

Rat CD32a, His Tag (Cat. No. CDA-R52H5) captured on NTA-Series S sensor chip can bind Rituximab with an affinity constant of 15.1 μM as determined in a SPR assay (Biacore 8K) (QC tested).

CDA-R52H4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Rhesus macaque CD32a, His Tag (Cat. No. CDA-R52H4) captured on CM5 Chip via anti-His antibody can bind Rituximab with an affinity constant of 3.89 μM as determined in SPR assay (Biacore T200) (QC tested).

Synonym Name

CD32a,FCGR2A,CD32,FCG2 ,FCGR2A1,IGFR2

Background

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIM­bearing receptors may also be coexpressed and co­engaged by specific ligands. CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
VIB-9600 VIB-9600; MEDI-9600 Phase 1 Clinical Medimmune Llc, Viela Bio Autoimmune Diseases Details

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