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Integrin alpha 5 beta 1

Brief Information

Name:Integrin alpha-5/beta-1
Target Synonym:Integrin alpha5beta1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Part of Bioactivity data

IT1-H82Wa-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human ITGA5&ITGB1 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT1-H82Wa) captured on Biotin CAP-Series S Sensor Chip can bind Human Fibronectin with an affinity constant of 4.4 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

IT1-H52W5-ELISA
Human ITGA5&ITGB1 Heterodimer Protein, His Tag&Tag FreeHuman ITGA5&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W5) ELISA bioactivity

Immobilized Human Fibronectin at 2 μg/mL (100 μL/well) can bind Human ITGA5&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W5) with a linear range of 0.2-2 ng/mL (QC tested).

Synonym Name

Integrin alpha 5 beta 1,ITGA5&ITGB1

Background

Integrin alpha 5 beta 1 / Integrin α5β1, which is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development., is composed of α5 (ITGA5/CD49e) and β1 (ITGB1/CD29) subunits. Integrins are adhesion receptors that transmit bidirectional signals across the plasma membrane. The Integrin alpha 5 beta 1 and its primary extracellular matrix ligand fibronectin (Fn) are of great biological importance.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human endostatin (Simcere) YH-16 Approved Jiangsu Xiansheng Pharmaceutical Co Ltd 恩度, Endu, Endostar Mainland China Carcinoma, Non-Small-Cell Lung Shandong Simcere Bio-Pharmaceutical Co Ltd 2005-09-12 Esophageal Neoplasms; Ascites; Osteosarcoma; Brain metastases; Pleural Effusion, Malignant; Carcinoma, Non-Small-Cell Lung Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
MINT-1526A MINT-1526A Phase 1 Clinical Genentech Inc Neoplasms Details
Pegylated recombinant human endostatin (Tsinghua University) M-2ES Phase 1 Clinical Tsinghua University, Beijing Protgen Biotechnology Development Co Ltd Solid tumours; Pancreatic Neoplasms; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Risuteganib ALG-1001 Phase 2 Clinical Allegro Ophthalmics Retinal Diseases; Diabetic macular oedema; Diabetic Retinopathy; Macular Degeneration Details

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