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Integrin alpha 5 beta 1

Integrin alpha 5 beta 1 Molecule Information

Name:Integrin alpha-5/beta-1
Target Synonym:Integrin alpha5beta1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
IT1-H52W5 Human Human Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer Protein, His Tag&Tag Free
IT1-H52W5-structure
IT1-H52W5-sds
IT1-H52W5-elisa_1

Integrin alpha 5 beta 1 Part of Bioactivity data

IT1-H52W5-BLI
Human ITGA5&ITGB1 Heterodimer Protein, His Tag&Tag FreeHuman ITGA5&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W5) ELISA bioactivity

Immobilized Human Fibronectin at 2 μg/mL (100 μL/well) can bind Human ITGA5&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W5) with a linear range of 0.2-2 ng/mL (QC tested).

Integrin alpha 5 beta 1 Molecule Synonym Name

Integrin alpha 5 beta 1,ITGA5&ITGB1,ITGA5&B1

Integrin alpha 5 beta 1 Molecule Background

Integrin alpha 5 beta 1 / Integrin ¦Á5¦Â1, which is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development., is composed of ¦Á5 (ITGA5/CD49e) and ¦Â1 (ITGB1/CD29) subunits. Integrins are adhesion receptors that transmit bidirectional signals across the plasma membrane. The Integrin alpha 5 beta 1 and its primary extracellular matrix ligand fibronectin (Fn) are of great biological importance.

Integrin alpha 5 beta 1 References

Integrin alpha 5 beta 1 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human endostatin (Simcere) YH-16 Approved Jiangsu Xiansheng Pharmaceutical Co Ltd 恩度, Endu, Endostar Mainland China Carcinoma, Non-Small-Cell Lung s:42:"Shandong Simcere Bio-Pharmaceutical Co Ltd"; 2005-09-12 Esophageal Neoplasms; Small Cell Lung Carcinoma; Osteosarcoma; Pleural Effusion, Malignant; Brain metastases; Carcinoma, Non-Small-Cell Lung Details

Integrin alpha 5 beta 1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Risuteganib ALG-1001 Phase 2 Clinical Allegro Ophthalmics Retinal Diseases; Diabetic macular oedema; Diabetic Retinopathy; Macular Degeneration Details
Pegylated recombinant human endostatin (Tsinghua University) M-2ES Phase 1 Clinical Tsinghua University, Beijing Protgen Biotechnology Development Co Ltd Pancreatic Neoplasms; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
MINT-1526A MINT-1526A Phase 1 Clinical Genentech Inc Neoplasms Details

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