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Your Position: Home > TSLP

TSLP

Brief Information

Name:Thymic stromal lymphopoietin
Target Synonym:Thymic stromal lymphopoietin,TSLP
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:NDA/BLA

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Cat. No. Species Product Description Structure Purity Feature
TSP-R52H3 Rat Rat TSLP Protein, His Tag
TSP-R52H3-structure
TSP-R52H3-sds
TSP-C82E3 Cynomolgus Biotinylated Cynomolgus TSLP Protein, His,Avitag™
TSP-C82E3-structure
TSP-C82E3-sds
TSP-C82E3-elisa_1
TSP-M82E3 Mouse Biotinylated Mouse TSLP Protein, His,Avitag™
TSP-M82E3-structure
TSP-C52H8 Cynomolgus Cynomolgus TSLP Protein, His Tag
TSP-C52H8-structure
TSP-C52H8-sds
TSP-C52H8-elisa_1
TSP-C52H4 Cynomolgus Cynomolgus TSLP (R127A, R130S) Protein, His Tag
TSP-C52H4-structure
TSP-C52H4-sds
TSP-C52H4-elisa_1
TSP-M52H8 Mouse Mouse TSLP Protein, His Tag
TSP-M52H8-structure
TSP-M52H8-sds
TSP-H5255 Human Human TSLP (R127A, R130A) Protein, Mouse IgG2a Fc Tag
TSP-H5255-structure
TSP-H5255-sds
TSP-H5255-elisa_1
TSP-H82E0 Human Biotinylated Human TSLP (R127A, R130A) Protein, His,Avitag™
TSP-H82E0-structure
TSP-H82E0-sds
TSP-H82E0-elisa_1
TSP-H52Ha Human Human TSLP (R127A, R130A) Protein, His Tag
TSP-H52Ha-structure
TSP-H52Ha-sds
TSP-H52Ha-elisa_1
TSP-H52Ha-elisa_2
TSP-H52Hb Human Human TSLP Protein, His Tag
TSP-H52Hb-structure
TSP-H52Hb-sds
TSP-H52Hb-elisa_1
TSP-H52Hb-elisa_2
TSP-H82Eb Human Biotinylated Human TSLP Protein, His,Avitag™
TSP-H82Eb-structure
TSP-H82Eb-sds
TSP-H82Eb-elisa_1

Part of Bioactivity data

TSP-H52Ha-SPR
Human_FcRn_Heterodimer_Protein_SPR

Captured Human TSLP (R127A, R130A), His Tag (Cat. No. TSP-H52Ha) on CM5 Chip via anti-His antibody, can bind Human TSLP R, Fc Tag (Cat. No. TSR-H525a) with an affinity constant of 4.22 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Protocol
TSP-H52Hb-SPR
Human_FcRn_Heterodimer_Protein_SPR

Captured Human TSLP, His Tag (Cat. No. TSP-H52Hb) on CM5 Chip via anti-His antibody, can bind Human TSLP R, Fc Tag (Cat. No. TSR-H525a) with an affinity constant of 1.81 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

TSLP

Background

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NOV-14 NOV-14 Phase 1 Clinical Morphosys Ag, Novartis Pharma Ag Asthma Details
CM-326 CM-326 Phase 1 Clinical Connaught Biomedical Technology (Chengdu) Co Ltd Autoimmune Diseases; Asthma Details
CSJ-117 CSJ-117 Phase 2 Clinical Novartis Pharma Ag Asthma; Pulmonary Disease, Chronic Obstructive Details

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