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TSLP Molecule Information

Name:Thymic stromal lymphopoietin
Target Synonym:TSLP
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase ?

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TSLP Molecule Synonym Name


TSLP Molecule Background

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

TSLP References

TSLP Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
RG-7258 RG-7258 Phase Ⅰ Roche Asthma Details
Tezepelumab AMG-157; MEDI-9929 Phase Ⅲ Amgen, AstraZeneca Asthma Details

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