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Your Position: Home > TSLP

TSLP

Brief Information

Name:Thymic stromal lymphopoietin
Target Synonym:Thymic stromal lymphopoietin,TSLP
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:23
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
FRT-P012 Human Human TSLP / IL-7Rα & TSLP R Inhibitor Screening Kit (TR-FRET)
TSP-H5254 Human Human TSLP (R127A, R130A) Protein, Fc Tag (MALS verified)
TSP-H5254-structure
TSP-H5254-sds
TSP-H5253 Human Human TSLP Protein, Fc Tag (MALS verified)
TSP-H5253-structure
TSP-H5253-sds
TSP-HP2H4 Human PE-Labeled Human TSLP Protein, His Tag (Site-specific conjugation)
TSP-HP2H4-structure
CEA-C074 Human ClinMax™ Human TSLP ELISA Kit
TSP-H5243 Human Human TSLP Protein (R127A, R130A), His Tag (MALS verified)
TSP-H5243-structure
TSP-H5243-sds
TSP-R52H3 Rat Rat TSLP Protein, His Tag
TSP-R52H3-structure
TSP-R52H3-sds
TSP-C82E3 Cynomolgus Biotinylated Cynomolgus TSLP Protein, His,Avitag™ (MALS verified)
TSP-C82E3-structure
TSP-C82E3-sds
TSP-M82E3 Mouse Biotinylated Mouse TSLP Protein, His,Avitag™
TSP-M82E3-structure
TSP-M82E3-sds
TSP-C52H8 Cynomolgus Cynomolgus TSLP Protein, His Tag
TSP-C52H8-structure
TSP-C52H8-sds
TSP-C52H4 Cynomolgus Cynomolgus TSLP (R127A, R130S) Protein, His Tag (HPLC verified)
TSP-C52H4-structure
TSP-C52H4-sds
TSP-C52H4-hplc
TSP-M52H8 Mouse Mouse TSLP Protein, His Tag (MALS verified)
TSP-M52H8-structure
TSP-M52H8-sds
TSP-H5255 Human Human TSLP (R127A, R130A) Protein, Mouse IgG2a Fc Tag (MALS verified)
TSP-H5255-structure
TSP-H5255-sds
TSP-H82E0 Human Biotinylated Human TSLP (R127A, R130A) Protein, His,Avitag™ (MALS verified)
TSP-H82E0-structure
TSP-H82E0-sds
TSP-H52Ha Human Human TSLP (R127A, R130A) Protein, His Tag (MALS verified)
TSP-H52Ha-structure
TSP-H52Ha-sds
TSP-H52Hb Human Human TSLP Protein, His Tag, premium grade
TSP-H52Hb-structure
TSP-H52Hb-sds
TSP-H82Eb Human Biotinylated Human TSLP Protein, His,Avitag™ (MALS verified)
TSP-H82Eb-structure
TSP-H82Eb-sds
ACRO Quality

Part of Bioactivity data

TSP-HP2H4-Cell-based assay
TSLP FACS

5e5 of Human TSLP R (Luc) HEK293 Reporter Cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human TSLP Protein, His Tag (Cat. No. TSP-HP2H4) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

Protocol
TSP-H5243-Cell-based assay
TSLP FACS

2e5 of Human TSLP R (Luc) HEK293 Reporter Cells were stained with 100 μL of 1 μg/mL of Human TSLP Protein (R127A, R130A), His Tag (Cat. No. TSP-H5243) and negative control protein respectively, washed and then followed by PE anti-His Tag Antibody and analyzed with FACS (Routinely tested).

Protocol
TSP-H5254-SPR
TSLP SPR

Human TSLP R, Fc Tag (Cat. No. TSR-H525a) immobilized on CM5 Chip can bind Human TSLP (R127A, R130A) Protein, Fc Tag (Cat. No. TSP-H5254) with an affinity constant of 6.63 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
TSP-H5253-SPR
TSLP SPR

Human TSLP R, Fc Tag (Cat. No. TSR-H525a) immobilized on CM5 Chip can bind Human TSLP Protein, Fc Tag (Cat. No. TSP-H5253) with an affinity constant of 47.2 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

TSLP

Background

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tezepelumab AMG-157; MEDI-9929 Approved Amgen Inc Tezspire United States Asthma Astrazeneca Ab 2021-12-17 Eosinophilic Esophagitis; Hypersensitivity; Dermatitis, Atopic; Hypersensitivity, Immediate; Bronchial Diseases; Pulmonary Disease, Chronic Obstructive; Respiratory Hypersensitivity; Sinusitis; Asthma; Granulomatosis with Polyangiitis; Lung Diseases; Immune System Diseases; Chronic Urticaria; Respiratory Tract Diseases; Nasal Polyps; Anaphylaxis; Carcinoma; Lung Diseases, Obstructive Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Bosakitug BSI-045B; TQC-2731; TQC2731 Phase 3 Clinical Boaoxin Biotechnology(Nanjing) Co Ltd Nasal Polyps; Sinusitis; Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
Solrikitug MK-8226; NSI-8226 Phase 2 Clinical Merck & Co Inc Hypertension; Eosinophilic Esophagitis; Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
Ecleralimab CSJ-117; NOV-14 Phase 2 Clinical Novartis Pharma Ag Asthma; Pulmonary Disease, Chronic Obstructive Details
WIN-1001X WIN-1001X Phase 2 Clinical Whanin Pharmaceutical Co Ltd Nerve Degeneration; Parkinson Disease Details
PF-07275315 PF-07275315 Phase 2 Clinical Pfizer Inc Dermatitis, Atopic Details
Lunsekimig SAR-443765 Phase 2 Clinical Sanofi Nasal Polyps; Asthma; Sinusitis; Inflammation; Dermatitis, Atopic Details
AZD-8630 AZD-8630; AMG-104 Phase 2 Clinical Astrazeneca Plc, Amgen Inc Asthma Details
TAVO-101 TAVO-101; TAVO101 Phase 2 Clinical Tavotek Biotherapeutics (Hong Kong) Ltd Dermatitis, Atopic; Hypersensitivity Details
SHR-1905 SHR-1905; AIO-001; GSK-5784283 Phase 2 Clinical Shanghai Hengrui Pharmaceutical Co Ltd Nasal Polyps; Respiratory Tract Diseases; Sinusitis; Asthma; Pulmonary Disease, Chronic Obstructive Details
CM-326(Connaught Biomedical Technology) CM326; CM-326 Phase 2 Clinical Keymed Biosciences Co Ltd Nasal Polyps; Sinusitis; Asthma; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
PF-06342674 RN-168; PF-6342674; PF-06342674; ZB-168 Phase 1 Clinical Pfizer Inc Diabetes Mellitus, Type 1; Multiple Sclerosis Details
HBM-9378 HBM-9378; SKB378; SKB-378; A-378; WIN378; WIN-378 Phase 1 Clinical Harbour Biomed, Sichuan Kelun-Biotech Biopharmaceutical Co Ltd Asthma; Pulmonary Disease, Chronic Obstructive Details
HB-0056 HB-0056; HB0056 Phase 1 Clinical Shanghai Huaota Biopharmaceutical Co Ltd Asthma Details
APG-333 APG333; APG-333; PR018; PR-018 Phase 1 Clinical Apogee Therapeutics Inc Asthma Details
SAR-444765 SAR444765; SAR-444765 Phase 1 Clinical Sanofi Inflammation Details
CM-512 CM512; CM-512 Phase 1 Clinical Keymed Biosciences Co Ltd Nasal Polyps; Asthma; Sinusitis; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic Details
IBI-3002 IBI3002; IBI-3002 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Asthma Details
GB-0895 GB-0895 Phase 1 Clinical Generate Biomedicines Inc Immune System Diseases; Asthma Details
CDX-622 CDX-622 Phase 1 Clinical Celldex Therapeutics Inc Fibrosis; Inflammation; Hypersensitivity Details
STSA-1201 STSA-1201; STSA1201 Phase 1 Clinical Staidson(Beijing) Biopharmaceuticals Co Ltd Asthma Details
LQ043H LQ043H Phase 1 Clinical Shanghai Novamab Biopharmaceuticals Co Ltd Asthma Details
GR2002 GR2002 Phase 1 Clinical Genrix (Shanghai) Biopharmaceutical Co Ltd Nasal Polyps; Asthma; Sinusitis; Dermatitis, Atopic Details
QX-008N QX008N; QX-008N Phase 1 Clinical Qyuns Therapeutics Co Ltd Asthma; Pulmonary Disease, Chronic Obstructive Details

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