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Your Position: Home > IL-1 Rrp2

IL-1 Rrp2

Brief Information

Name:Interleukin-36 receptor
Target Synonym:Interleukin-1 Receptor-Related Protein 2,Interleukin-1 Receptor-Like 2,IL-1Rrp2,Interleukin 1 Receptor Like 2,EC:,IL-36R,IL1RRP2,IL-36 Receptor,IL1R-Rp2,IL1RL2,IL-1 Receptor-Related Protein 2
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Part of Bioactivity data

 IL-1 Rrp2 ELISA

Immobilized Anti-IL36R Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind Human IL-1 Rrp2 (C154S, C262S) Protein, His Tag (Cat. No. IL2-H52H4) with a linear range of 4-125 ng/mL (QC tested).

IL-1 Rrp2 MALS images

The purity of Human IL-1 Rrp2 (C154S, C262S) Protein, His Tag (Cat. No. IL2-H52H4) is more than 90% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

Synonym Name

IL-1 R6,IL-1 Rrp2,IL1RL2,IL-1RL2,IL1Rrp2,IL-1Rrp2,IL1RRP2,IL-36R


The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9).  All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Spesolimab BI-655130 Approved C.H. Boehringer Sohn Ag & Co. Kg 圣利卓, Spevigo United States Psoriasis Boehringer Ingelheim Pharmaceuticals Inc 2022-09-01 Netherton Syndrome; Psoriasis; Colitis, Ulcerative; Hidradenitis Suppurativa; Crohn Disease; Dermatitis, Atopic Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Imsidolimab ANB-019 Phase 3 Clinical Anaptysbio Inc Acne Vulgaris; Ichthyosis; Psoriasis; Acneiform Eruptions; Hidradenitis Suppurativa Details
HB-0034 HB-0034 Phase 2 Clinical Shanghai Huaota Biopharmaceutical Co Ltd Psoriasis Details
IMG-008 IMG008 Phase 1 Clinical Inmagene Biopharmaceuticals Ltd Autoimmune Diseases; Inflammation Details

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