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IL-1 Rrp2

IL-1 Rrp2 Molecule Information

Name:Interleukin-36 receptor
Target Synonym:IL1RL2?IL-1 Receptor-Related Protein 2?Interleukin-1 Receptor-Related Protein 2?EC:3.2.2.6?IL-1Rrp2?Interleukin 1 Receptor Like 2?Interleukin-1 Receptor-Like 2?IL-36 Receptor?IL1RRP2?IL-36R?IL1R-Rp2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

IL-1 Rrp2 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IL2-H52H4 Human Human IL-1 Rrp2 / IL-1 R6 (C154S, C262S) Protein, His Tag (MALS verified)
IL2-H52H4-structure
IL2-H52H4-sds
IL2-H52H4-elisa_1
IL2-C52H5 Cynomolgus Cynomolgus IL-1 Rrp2 / IL-1 R6 Protein, His Tag
IL2-C52H5-structure
IL2-C52H5-sds
IL2-H5254 Human Human IL-1 Rrp2 / IL-1 R6 Protein, Fc Tag
IL2-H5254-structure
IL2-H5254-sds
IL2-H5254-elisa_1
IL2-H52H6 Human Human IL-1 Rrp2 / IL-1 R6 Protein, His Tag
IL2-H52H6-structure
IL2-H52H6-sds
IL2-H52H6-elisa_1

IL-1 Rrp2 Part of Bioactivity data

IL2-H5254-ELISA
Human IL-1 Rrp2, Fc TagHuman IL-1 Rrp2, Fc Tag (Cat. No. IL2-H5254) ELISA bioactivity

Immobilized Recombinant Human IL-36Ra / IL-1F5 at 2 μg/mL (100 μL/well) can bind Human IL-1 Rrp2, Fc Tag (Cat. No. IL2-H5254) with a linear range of 0.156-5 μg/mL (QC tested).

IL2-H52H4-MALS-HPLC
Human IL-1 Rrp2 (C154S, C262S), His Tag (Cat. No. ) MALS images

The purity of Human IL-1 Rrp2 (C154S, C262S), His Tag(Cat. No. IL2-H52H4) was more than 90% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human IL-1 Rrp2 (C154S, C262S), His TagHuman IL-1 Rrp2 (C154S, C262S), His Tag (Cat. No. IL2-H52H4) ELISA bioactivity

Immobilized Human IL-1 Rrp2 (C154S, C262S), His Tag (Cat. No. IL2-H52H4) at 1 μg/mL (100 μL/well) can bind Anti-Human IL-1 Rrp2 MAb, Human IgG with a linear range of 0.2-3 ng/mL (Routinely tested).

IL-1 Rrp2 Molecule Synonym Name

IL-1 R6,IL-1 Rrp2,IL1RL2,IL-1RL2,IL1Rrp2,IL-1Rrp2,IL1RRP2,IL-36R

IL-1 Rrp2 Molecule Background

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9).  All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

IL-1 Rrp2 References

IL-1 Rrp2 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ANB-019 ANB-019 Phase 2 Clinical Anaptysbio Psoriasis Details
Spesolimab BI-655130 Phase 3 Clinical C.H. Boehringer Sohn Ag & Co. Kg Psoriasis; Colitis, Ulcerative; Dermatitis, Atopic; Crohn Disease Details

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