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IL-1 Rrp2

Brief Information

Name:Interleukin-36 receptor
Target Synonym:IL1RL2,IL-1 Receptor-Related Protein 2,Interleukin-1 Receptor-Related Protein 2,EC:,IL-1Rrp2,Interleukin 1 Receptor Like 2,Interleukin-1 Receptor-Like 2,IL-36 Receptor,IL1RRP2,IL-36R,IL1R-Rp2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

Human IL-1 Rrp2, Fc TagHuman IL-1 Rrp2, Fc Tag (Cat. No. IL2-H5254) ELISA bioactivity

Immobilized Recombinant Human IL-36Ra / IL-1F5 at 2 μg/mL (100 μL/well) can bind Human IL-1 Rrp2, Fc Tag (Cat. No. IL2-H5254) with a linear range of 0.156-5 μg/mL (QC tested).

Human IL-1 Rrp2 (C154S, C262S), His Tag (Cat. No. ) MALS images

The purity of Human IL-1 Rrp2 (C154S, C262S), His Tag(Cat. No. IL2-H52H4) is more than 90% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

Synonym Name

IL-1 R6,IL-1 Rrp2,IL1RL2,IL-1RL2,IL1Rrp2,IL-1Rrp2,IL1RRP2,IL-36R


The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9).  All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Imsidolimab ANB-019 Phase 2 Clinical Anaptysbio Acne Vulgaris; Ichthyosis; Psoriasis; Acneiform Eruptions; Hidradenitis Suppurativa Details
Spesolimab BI-655130 Phase 3 Clinical C.H. Boehringer Sohn Ag & Co. Kg Psoriasis; Colitis, Ulcerative; Hidradenitis Suppurativa; Dermatitis, Atopic; Crohn Disease Details

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