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Your Position: Home > Fc gamma RIIB / CD32b

Fc gamma RIIB / CD32b

Brief Information

Name:Low affinity immunoglobulin gamma Fc region receptor II-b
Target Synonym:FCGR2C,Fc-Gamma-RIIc,IgG Fc Receptor II-C,Fc-gamma-RIIb,FCGR2B,IGFR2,CD32,Fc Fragment Of IgG Receptor IIb,Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32),Fc Gamma Receptor IIb,IgG Fc Receptor II-B,Fc-Gamma RII-B,FcRII-B,CDw32,FCG2,Low Affinity Immun
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

CDB-C5224-SPR
Human_FcRn_Heterodimer_Protein_SPR

Cynomolgus CD32b, His Tag (Cat. No. CDB-C5224) captured on CM5 chip via anti-His antibody can Herceptin® with an affinity constant of 11.9 μM as determined in a SPR assay (Biacore T200) (QC tested).

CDB-C82E4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Captured Biotinylated Cynomolgus CD32b, His,Avitag (Cat. No. CDB-C82E4) on Biotin CAP - Series S sensor Chip can bind MabThera® (Rituximab) with an affinity constant of 4.94 μM as determined in a SPR assay (Biacore T200) (QC tested).

Synonym Name

FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32

Background

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Obexelimab AMG-729; XmAb-5871 Phase 3 Clinical Xencor Immunoglobulin G4-Related Disease; Arthritis, Rheumatoid; Autoimmune Diseases; Lupus Erythematosus, Systemic Details
BI-1206 6G-11; BI-1206 Phase 2 Clinical Bioinvent International Lymphoma, B-Cell; Solid tumours; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
PRV-3279 MGD-010; PRV-3279; CD32BxCD-79B Phase 2 Clinical Macrogenics Autoimmune Diseases; Lupus Erythematosus, Systemic Details

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