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Your Position: Home > APRIL

APRIL

Brief Information

Name:Tumor necrosis factor ligand superfamily member 13
Target Synonym:Tumor Necrosis Factor Ligand 7B,CD256 Antigen,TNLG7B,CD256,TNF- and APOL-related leukocyte expressed ligand 2,TNFSF13,TNF-related death ligand 1,ZTNF2,TALL-2,APRIL,Tumor necrosis factor ligand superfamily member 13,TNF Superfamily Member 13,Tumor Necrosis Factor (Ligand) Superfamily, Member 13,TRDL-1,TALL2,Tumor Necrosis Factor Superfamily Member 13,Tumor Necrosis Factor-Like Protein ZTNF2,UNQ383/PRO715,A Proliferation-Inducing Ligand,Tumor Necrosis Factor-Related Death Ligand-1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Approved

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Part of Bioactivity data

APL-H52D1-BLI
 APRIL BLI

Loaded Human APRIL, His,Flag Tag, active trimer (Cat. No. APL-H52D1) on HIS1K Biosensor, can bind Human BCMA, Fc Tag (Cat. No. BC7-H5254) with an affinity constant of 1.88 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

APL-H52D1-BLI
 APRIL BLI

Loaded Human APRIL, His,Flag Tag, active trimer (Cat. No. APL-H52D1) on HIS1K Biosensor, can bind Human TACI/TNFRSF13B, Fc Tag (Cat. No. TAI-H5256) with an affinity constant of 75 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

APRIL,TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2

Background

APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Telitacicept RCT-18; RC-18; RCT18; RC18 Approved RemeGen Co Ltd 泰爱 Mainland China Lupus Erythematosus, Systemic RemeGen Co Ltd 2021-03-09 Myasthenia Gravis; Multiple Sclerosis, Relapsing-Remitting; Glomerulonephritis, IGA; Arthritis, Rheumatoid; Sjogren's Syndrome; Multiple Sclerosis; Neuromyelitis Optica; Lupus Erythematosus, Systemic Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AUR-200 AUR-200 Phase 1 Clinical Thunderbolt Pharma Inc Autoimmune Diseases Details
Anti-BCMA CAR T-cell therapy (Huazhong University of Science and Technology) Clinical Huazhong University Of Science And Technology Multiple Myeloma Details
APRIL CAR-T Cell therapy (Yake Biotechnology) Phase 1 Clinical Shanghai YaKe Biotechnology Co Ltd Multiple Myeloma Details
RO-7297089 RO-7297089; AFM-26; RG-6296 Genentech Inc Details
Sibeprenlimab VIS-649 Phase 1 Clinical Visterra Glomerulonephritis, IGA Details
BION-1301 BION-1301 Aduro Biotech Details
anti-TriPRIL CAR T-cell therapy(Massachusetts General Hospital) Phase 1 Clinical Massachusetts General Hospital Multiple Myeloma Details
Atacicept TACI-Ig Phase 2 Clinical Zymogenetics Glomerulonephritis, IGA; Arthritis, Rheumatoid; Multiple Sclerosis; Optic Neuritis; Lupus Nephritis; Lupus Erythematosus, Systemic Details

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