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IL-17 RC

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Cat. No. Species Product Description Structure Purity Feature
ILC-H5259 Human Human IL-17 RC Protein, Fc Tag (MALS verified)
ILC-H5259-structure
ILC-H5259-sds
ILC-H5259-elisa_1
ILC-H5259-elisa_2

Part of Bioactivity data

ILC-H5259-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-17A Protein, Tag Free (Cat. No. ILA-H5118) immobilized on CM5 Chip can Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) with an affinity constant of 72.8 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

ILC-H5259-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human IL-17A Protein, His,Avitag™ (Cat. No. ILA-H82Q1) captured on Biotin CAP - Series S sensor Chip can bind Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) with an affinity constant of 40.9 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

IL-17 RC,IL-17RC,IL17Rhom,IL-17 receptor C,IL-17RL,ZcytoR14

Background

Interleukin-17 receptor C (IL-17 RC), also known as IL17Rhom, IL-17RL, is the receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. IL-17A activity is inhibited by IL-17RA, IL-17F is inhibited by IL-17RC, and a combination of soluble IL-17RA/IL-17RC receptors is required for inhibition of the IL-17F/IL-17A activity. Furthermore, activation of IL17RC can lead to the induction of expression of inflammatory chemokines and cytokines such as CXCL1.

Clinical and Translational Updates

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