IL-17 RC Protein - ACROBiosystems

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IL-17 RC


ILC-H5259	Human	Human IL-17 RC Protein, Fc Tag (MALS verified)

Cat. No.

Species

Product Description

Structure

Purity

Feature

ILC-H5259

Human

Human IL-17 RC Protein, Fc Tag (MALS verified)

Part of Bioactivity data

ILC-H5259-SPR

Human IL-17A Protein, Tag Free (Cat. No. ILA-H5118) immobilized on CM5 Chip can Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) with an affinity constant of 72.8 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

ILC-H5259-SPR

Biotinylated Human IL-17A Protein, His,Avitag™ (Cat. No. ILA-H82Q1) captured on Biotin CAP - Series S sensor Chip can bind Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) with an affinity constant of 40.9 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

IL-17 RC,IL-17RC,IL17Rhom,IL-17 receptor C,IL-17RL,ZcytoR14

Background

Interleukin-17 receptor C (IL-17 RC), also known as IL17Rhom, IL-17RL, is the receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. IL-17A activity is inhibited by IL-17RA, IL-17F is inhibited by IL-17RC, and a combination of soluble IL-17RA/IL-17RC receptors is required for inhibition of the IL-17F/IL-17A activity. Furthermore, activation of IL17RC can lead to the induction of expression of inflammatory chemokines and cytokines such as CXCL1.

Clinical and Translational Updates